Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Fluoride Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL583553 | 0.96 | — | — | |
| Ammonia Solution, Strong SCHEMBL2892185 | 0.92 | — | — | |
| SCHEMBL29167943 | 0.92 | SLC34A1 (0.50) | — | |
| Ammonia Solution, Strong SCHEMBL28500032 | 0.88 | — | — | |
| Lithium Ion SCHEMBL28390201 | 0.87 | — | — | |
| Ammonia Solution, Strong SCHEMBL7594155 | 0.85 | SLC34A1 (0.53) | — | |
| Phosphoric Acid SCHEMBL4931344 | 0.83 | SLC34A1 (0.50) | — | |
| Phosphoric Acid SCHEMBL29078233 | 0.83 | SLC34A1 (0.50) | — | |
| SCHEMBL28271386 | 0.83 | SLC34A1 (0.50) | — | |
| Lithium Ion SCHEMBL29135346 | 0.83 | SLC34A1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8545819-B2 | Oral care toothpowder composition with fluoride ion source | COLGATE-PALMOLIVE COMPANY (US) | 2013-10-01 | — | — | US | claimed |
| US-10695281-B2 | Late stage addition of rheology modifier | THE PROCTER & GAMBLE COMPANY (US) | 2020-06-30 | — | — | US | disclosed |
| EP-3665282-A1 | APTAMERS FOR ORAL CARE APPLICATIONS | THE PROCTER & GAMBLE COMPANY (US) | 2020-06-17 | — | — | EP | disclosed |
| US-20190091126-A1 | LATE STAGE ADDITION OF RHEOLOGY MODIFIER | PROCTER & GAMBLE (US) | 2019-03-28 | — | — | US | disclosed |
| WO-2019032795-A1 | APTAMERS FOR ORAL CARE APPLICATIONS | THE PROCTER & GAMBLE COMPANY (US) | 2019-02-14 | — | — | WO | disclosed |
| US-20190048349-A1 | APTAMERS FOR ORAL CARE APPLICATIONS | NEOVENTURES BIOTECHNOLOGY INC. (CA) | 2019-02-14 | — | — | US | disclosed |
| US-10172778-B2 | Late stage addition of rheology modifier | THE PROCTER & GAMBLE COMPANY (US) | 2019-01-08 | — | — | US | disclosed |
| EP-3062886-B1 | PROCESS FOR MAKING PERSONAL CARE COMPOSITION USING COMPACTED RHEOLOGY MODIFIERS | PROCTER & GAMBLE (US) | 2018-11-21 | — | — | EP | disclosed |
| EP-3062885-B1 | LATE STAGE ADDITION OF RHEOLOGY MODIFIER | PROCTER & GAMBLE (US) | 2018-02-28 | — | — | EP | disclosed |
| CN-107530240-A | Low moisture Dentrifice composition | 高露洁-棕榄公司 | 2018-01-02 | — | — | CN | disclosed |
| CN-1313756-A | Oral liquid mucoadhesive compositions | PROCTER & GAMBLE (US) | 2001-09-19 | — | — | CN | disclosed |
| CN-1313754-A | Oral liquid mucoadhesive compositions | PROCTER & GAMBLE (US) | 2001-09-19 | — | — | CN | disclosed |
| CN-1313757-A | Oral liquid mucoadhesive compositions | PROCTER & GAMBLE (US) | 2001-09-19 | — | — | CN | disclosed |
| WO-2001034107-A1 | ORAL COMPOSITIONS PROVIDING OPTIMAL SURFACE CONDITIONING | THE PROCTER & GAMBLE COMPANY (US) | 2001-05-17 | — | — | WO | disclosed |
| WO-2000056276-A1 | ANTI-CARIES ORAL CARE COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 2000-09-28 | — | — | WO | disclosed |
| CN-1237894-A | Dentifrice compositions containing polyphosphate and fluoride | PROCTER & GAMBLE (US) | 1999-12-08 | — | — | CN | disclosed |
| CN-2160255-Y | Fluorine ion penetration type toothbrush | XU SHUMAN (CN) | 1994-04-06 | — | — | CN | disclosed |
| CN-1062463-A | ANTICALCULUS ORAL COMPOSITION | COLGATE PALMOLIVE CO (US) | 1992-07-08 | — | — | CN | disclosed |
| US-4795630-A | ABRASIVE, HUMECTANT, BINDER, SURFACTANT AND WATER | LION CORPORATION (JP) | 1989-01-03 | — | — | US | disclosed |
| US-4198394-A | Sodium dihydrogen phosphate enhanced dentifrice composition | FAUNCE FRANK R | 1980-04-15 | — | — | US | disclosed |