SCHEMBL1708424

SCHEMBL1708424

CCc1nc2ccccc2n1-c1cccc2c1OC[C@H]2Nc1ccc2c(c1)OC[C@H]2CC(=O)[O-].[Na+]

nearest known ligand 0.35

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG known ✓ P37231 3/20 0.32
NTRK1 P04629 1/20 0.35
NTRK2 Q16620 1/20 0.35
L3MBTL1 Q9Y468 3/20 0.34
TSHR P16473 2/20 0.34
HTT P42858 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
ALDH1A1 P00352 3/20 0.33
MAPT P10636 3/20 0.33
LMNA P02545 1/20 0.33
MAPK1 P28482 2/20 0.32
FFAR1 O14842 5/20 0.32
PPARD Q03181 3/20 0.32
PPARA Q07869 1/20 0.32
GUCY1A1 Q02108 1/20 0.32
GUCY1B1 Q02153 1/20 0.32
BMI1 P35226 1/20 0.31
CHEK1 O14757 1/20 0.31
ATR Q13535 1/20 0.31
PDCD1 Q15116 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1707941 0.92 PPARG (0.39) NTRK1NTRK2L3MBTL1FFAR1PPARD
SCHEMBL1708167 0.92 PPARG (0.39) NTRK1NTRK2L3MBTL1FFAR1PPARD
SCHEMBL1708619 0.90 ADORA2B (0.31) FFAR1PPARDPPARG
SCHEMBL1708272 0.90 FFAR1 (0.35) MAPTFFAR1PPARDPPARGPPARA
SCHEMBL1708697 0.89 FFAR1 (0.34) NTRK1NTRK2L3MBTL1TSHRHTT
SCHEMBL1708260 0.86 FFAR1 (0.31) FFAR1GUCY1A1GUCY1B1
SCHEMBL1708289 0.86 FFAR1 (0.31) FFAR1PPARD
SCHEMBL1708168 0.85 NTRK1 (0.36) NTRK1NTRK2L3MBTL1TSHRHTT
SCHEMBL1707942 0.85 NTRK1 (0.36) NTRK1NTRK2L3MBTL1TSHRHTT
SCHEMBL1708110 0.84 PPARG (0.40) TSHRMAPK1FFAR1PPARDPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2440541-A1 NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF Takeda Pharmaceutical Company Limited (JP) 2012-04-18 EP disclosed
WO-2010143733-A1 NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-12-16 WO disclosed