Sugi Predict

Sugi Predict / Compounds / Chloroxine

Chloroxine

Chloroxine

SCHEMBL1714742

[Mg+2].[O-]c1c(Cl)cc(Cl)c2cccnc12.[O-]c1c(Cl)cc(Cl)c2cccnc12

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ATP4AATP4BGABBR1GABBR2HMGCR

The experimentally established mechanism targets of Chloroxine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 8/20 0.61
▸ MAPT P10636 7/20 0.61
▸ KDM4E B2RXH2 6/20 0.61
▸ LMNA P02545 6/20 0.61
▸ HTT P42858 6/20 0.61
▸ SMN1; SMN2 Q16637 6/20 0.61
▸ HSP90AA1 P07900 5/20 0.61
▸ MEN1 O00255 4/20 0.61
▸ KMT2A Q03164 4/20 0.61
▸ TDP1 Q9NUW8 4/20 0.61
▸ MMP14 P50281 3/20 0.61
▸ ALOX12 P18054 3/20 0.61
▸ OPRK1 P41145 3/20 0.61
▸ TP53 P04637 2/20 0.61
▸ CYP3A4 P08684 2/20 0.61
▸ ALOX15 P16050 2/20 0.61
▸ SLC6A2 P23975 2/20 0.61
▸ ALOX15B O15296 1/20 0.61
▸ NR1I2 O75469 1/20 0.61
▸ HTR1A P08908 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Chloroxine SCHEMBL4896774 0.98 ALDH1A1 (0.62) ALDH1A1MAPTKDM4ELMNAHTT
Chloroxine SCHEMBL1714028 0.96 ALDH1A1 (0.61) ALDH1A1MAPTKDM4ELMNAHTT
Chloroxine SCHEMBL29485694 0.96 ALDH1A1 (0.61) ALDH1A1MAPTKDM4ELMNAHTT
Chloroxine SCHEMBL325379 0.96 ALDH1A1 (0.61) ALDH1A1MAPTKDM4ELMNAHTT
Chloroxine SCHEMBL6677223 0.96 ALDH1A1 (0.61) ALDH1A1MAPTKDM4ELMNAHTT
Clioquinol SCHEMBL29353710 0.84 ALDH1A1 (0.64) ALDH1A1MAPTKDM4ELMNAHTT
Chloroxine SCHEMBL3350 0.76 KDM4E (1.00) ALDH1A1MAPTKDM4ELMNAHTT
Chloroxine SCHEMBL29399997 0.76 KDM4E (1.00) ALDH1A1MAPTKDM4ELMNAHTT
SCHEMBL14212958 0.76 KDM4E (0.62) ALDH1A1MAPTKDM4ELMNAHTT
Cloxyquin SCHEMBL1714880 0.76 KDM4E (0.59) ALDH1A1MAPTKDM4ELMNAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1486549-B1 ORGANIC ELECTROLUMINESCENT ELEMENT TOYOTA JIDOSHOKKI KK (JP) 2012-01-11 — — EP disclosed
EP-1755362-B1 ORGANIC EL DEVICE TOYOTA JIDOSHOKKI KK (JP) 2011-07-20 — — EP disclosed
US-7854998-B2 Organic EL devices KABUSHIKI KAISHA TOYOTA JIDOSHOKKI (JP) 2010-12-21 — — US disclosed
EP-1489154-B1 ORGANIC ELECTROLUMINESCENCE DEVICE TOYOTA JIDOSHOKKI KK (JP) 2009-05-13 — — EP disclosed
US-7521567-B2 Amine compound and uses thereof KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) 2009-04-21 — — US disclosed
US-20080290788-A1 Organic el Devices KABUSHIKI KAISHA TOYOTA JIDOSHOKKI (JP) 2008-11-27 — — US disclosed
US-7419727-B2 Organic electroluminescent device KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) 2008-09-02 — — US disclosed
US-7338720-B2 Organic electroluminescent element KABUSHIKI KAISHA TOYOTA JIDOSHOKKI (JP) 2008-03-04 — — US disclosed
US-7252892-B2 Organic electroluminescence device KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) 2007-08-07 — — US disclosed
EP-1755362-A1 ORGANIC EL DEVICE KABUSHIKI KAISHA TOYOTA JIDOSHOKKI (JP) 2007-02-21 — — EP disclosed
US-20070018568-A1 Organic electroluminescent device KABUSHIKI KAISHA TOYOTA JIDOSHOKKI (JP) 2007-01-25 — — US disclosed
US-20060228577-A1 Organic electroluminescent device KABUSHIKI KAISHA TOYOTA JIDOSHOKKI (JP) 2006-10-12 — — US disclosed
US-20060226421-A1 Amine compound and uses thereof KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KENKYUJO (JP) 2006-10-12 — — US disclosed
US-20060192473-A1 Organic electroluminescent device KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) 2006-08-31 — — US disclosed
EP-1599074-A1 ORGANIC ELECTROLUMINESCENT DEVICE Kabushiki Kaisha Toyota Jidoshokki (JP) 2005-11-23 — — EP disclosed
EP-1560469-A1 ORGANIC ELECTROLUMINESCENT DEVICE Kabushiki Kaisha Toyota Jidoshokki (JP) 2005-08-03 — — EP disclosed
US-20050089713-A1 Organic electroluminescent element KABUSHIKI KAISHA TOYOTA JIDOSHOKKI (JP) 2005-04-28 — — US disclosed
US-20050084707-A1 Organic electroluminescence device KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) 2005-04-21 — — US disclosed
EP-1489154-A1 ORGANIC ELECTROLUMINESCENCE DEVICE Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (JP) 2004-12-22 — — EP disclosed
EP-1486549-A1 ORGANIC ELECTROLUMINESCENT ELEMENT Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (JP) 2004-12-15 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060226421-A1 Amine compound and uses thereof PNMT, TYR, PAM ALDH1A1 580/4885MAPT 530/4885KDM4E 260/4885
US-20050084707-A1 Organic electroluminescence device ELAVL1, SELE, CELF2 ALDH1A1 227/4885MAPT 3064/4885KDM4E 2019/4885
US-20050089713-A1 Organic electroluminescent element SOD3, CELF2, SOD1 ALDH1A1 789/4885MAPT 3933/4885KDM4E 2269/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.