SCHEMBL17223095

SCHEMBL17223095

COc1ccc(C(OC[C@H]2O[C@](n3ccc(N)nc3=O)([SiH](C)C)[C@H](OC(C)(C)C)[C@@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.41

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TYMP P19971 6/20 0.41
SLC6A1 P30531 2/20 0.31
SLC6A11 P48066 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6363039 0.85 TYMP (0.40) TYMPSLC6A1SLC6A11
SCHEMBL17223101 0.83 TYMP (0.49) TYMP
SCHEMBL7897026 0.81 TYMP (0.43) TYMP
SCHEMBL30514382 0.80 TYMP (0.42) TYMPSLC6A1SLC6A11
SCHEMBL6835021 0.77 TYMP (0.39) TYMPSLC6A1SLC6A11
SCHEMBL7175441 0.77 TYMP (0.38) TYMP
SCHEMBL10276803 0.76 TYMP (0.44) TYMP
SCHEMBL28294844 0.75 LMNA (0.34)
SCHEMBL28294920 0.75 L3MBTL1 (0.36)
SCHEMBL917968 0.75 TYMP (0.40) TYMPSLC6A1SLC6A11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10730904-B2 Method for liquid-phase synthesis of nucleic acid TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2020-08-04 US disclosed
US-20190135852-A1 METHOD FOR LIQUID-PHASE SYNTHESIS OF NUCLEIC ACID TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2019-05-09 US disclosed
US-20150315229-A1 METHOD FOR LIQUID-PHASE SYNTHESIS OF NUCLEIC ACID TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-11-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150315229-A1 METHOD FOR LIQUID-PHASE SYNTHESIS OF NUCLEIC ACID POLM, POLRMT, RNMT TYMP 123/4885SLC6A1 4774/4885SLC6A11 4829/4885
US-20190135852-A1 METHOD FOR LIQUID-PHASE SYNTHESIS OF NUCLEIC ACID RNGTT, POLR2H, POLR2E TYMP 165/4885SLC6A1 4456/4885SLC6A11 4624/4885
US-10730904-B2 Method for liquid-phase synthesis of nucleic acid RNGTT, POLR2H, POLR2E TYMP 257/4885SLC6A1 4366/4885SLC6A11 4689/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.