Sugi Predict

Sugi Predict / Compounds / SCHEMBL1722537

SCHEMBL1722537

SCHEMBL1722537

N#CC=Cc1cccc(C(F)(F)F)c1

nearest known ligand 0.56

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ NFE2L2 Q16236 1/20 0.56
▸ FBP1 P09467 1/20 0.53
▸ ENPP2 Q13822 1/20 0.51
▸ P4HB P07237 2/20 0.47
▸ MEN1 O00255 1/20 0.47
▸ LMNA P02545 1/20 0.47
▸ HSP90AA1 P07900 1/20 0.47
▸ MAPT P10636 1/20 0.47
▸ PKM P14618 1/20 0.47
▸ KMT2A Q03164 1/20 0.47
▸ NPSR1 Q6W5P4 1/20 0.47
▸ MAOB P27338 7/20 0.44
▸ MAOA P21397 2/20 0.43
▸ HTT P42858 1/20 0.43
▸ THRB P10828 1/20 0.43
▸ L3MBTL1 Q9Y468 1/20 0.43
▸ KDM4E B2RXH2 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1722536 1.00 NFE2L2 (0.56) NFE2L2FBP1ENPP2P4HBMEN1
SCHEMBL2319221 0.82 FBP1 (0.57) NFE2L2FBP1P4HBMEN1LMNA
SCHEMBL2319217 0.82 FBP1 (0.57) NFE2L2FBP1P4HBMEN1LMNA
SCHEMBL10355224 0.82 ENPP2 (0.51) NFE2L2FBP1ENPP2MEN1LMNA
SCHEMBL3594422 0.81 RPS6KA3 (0.45) NFE2L2FBP1ENPP2KDM4E
SCHEMBL3594419 0.81 RPS6KA3 (0.45) NFE2L2FBP1ENPP2KDM4E
SCHEMBL13790316 0.79 NFE2L2 (0.82) NFE2L2FBP1P4HBMEN1LMNA
SCHEMBL9108500 0.79 POLB (0.49) NFE2L2NPSR1L3MBTL1
SCHEMBL9108496 0.79 POLB (0.49) NFE2L2NPSR1L3MBTL1
SCHEMBL14749829 0.78 ENPP2 (0.47) NFE2L2ENPP2MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111606824-B Beta-amino nitrile compound and preparation method thereof 东北师范大学 2023-03-14 — — CN claimed
CN-111606824-A Beta-amino nitrile compound and preparation method thereof 东北师范大学 2020-09-01 — — CN claimed
CN-104829460-B Synthesis method of cinacalcet hydrochloride and intermediate thereof 常州市阳光药业有限公司 2017-02-01 — — CN claimed
WO-2025099741-A1 PROCESS FOR THE PREPARATION OF NITROSAMINE FREE CINACALCET AND SALTS THEREOF MEGAFINE PHARMA (P) LTD. (IN) 2025-05-15 — — WO disclosed
CN-111606824-B Beta-amino nitrile compound and preparation method thereof 东北师范大学 2023-03-14 — — CN disclosed
EP-3164386-B1 PIPERIDINONE HERBICIDES FMC CORP (US) 2020-10-07 — — EP disclosed
CN-111606824-A Beta-amino nitrile compound and preparation method thereof 东北师范大学 2020-09-01 — — CN disclosed
EP-2406211-B1 A NEW METHOD FOR THE PREPARATION OF CINACALCET AND NEW INTERMEDIATES THEREOF MEGAFINE PHARMA P LTD (IN) 2018-06-27 — — EP disclosed
US-9944602-B2 Piperidinone herbicides FMC CORPORATION 2018-04-17 — — US disclosed
US-20170158638-A1 PIPERIDINONE HERBICIDES FMC CORPORATION 2017-06-08 — — US disclosed
EP-3164386-A1 PIPERIDINONE HERBICIDES E. I. du Pont de Nemours and Company (US) 2017-05-10 — — EP disclosed
WO-2007127445-A2 PROCESS FOR THE PREPARATION OF CINACALCET BASE TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 2007-11-08 — — WO disclosed
WO-2007127449-A1 PROCESS FOR THE PREPARATION OF CINACALCET BASE TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 2007-11-08 — — WO disclosed
US-20070259964-A1 Process for the preparation of cinacalcet base TEVA PHARMACEUTICALS USA, INC. 2007-11-08 — — US disclosed
US-7250533-B2 Process for preparing Cinacalcet hydrochloride TEVA PHARMACEUTICAL INDUSTRIES LTD (IL) 2007-07-31 — — US disclosed
US-20070043243-A1 Process for preparing Cinacalcet hydrochloride TEVA PHARMACEUTICALS USA, INC. 2007-02-22 — — US disclosed
US-7169924-B2 Pyrimidinone derivatives and their use in the treatment of atherosclerosis SMITHKLINE BEECHAM PLC (GB) 2007-01-30 — — US disclosed
WO-2006125026-A2 PROCESS FOR PREPARING CINACALCET HYDROCHLORIDE TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) 2006-11-23 — — WO disclosed
US-20040266822-A1 Amine derivative with potassium channel regulatory function, its preparation and use INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. (CN) 2004-12-30 — — US disclosed
EP-1386908-A1 AMINE DERIVATIVE WITH POTASSIUM CHANNEL REGULATORY FUNCTION, ITS PREPARATION AND USE Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. (CN) 2004-02-04 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170158638-A1 PIPERIDINONE HERBICIDES CYP1A1, CYP1B1, ARG1 NFE2L2 453/4885FBP1 1248/4885ENPP2 2721/4885
US-20070259964-A1 Process for the preparation of cinacalcet base KRAS, CA9, CA4 NFE2L2 3975/4885FBP1 2538/4885ENPP2 2342/4885
US-20040266822-A1 Amine derivative with potassium channel regulatory function, its preparation and use KCNMA1, KCNA5, KCNA1 NFE2L2 501/4885FBP1 2146/4885ENPP2 2282/4885
US-20070043243-A1 Process for preparing Cinacalcet hydrochloride SI, PRCP, CA9 NFE2L2 4160/4885FBP1 2546/4885ENPP2 900/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.