Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.65 |
| ▸ | CES1 | P23141 | 1/20 | 0.65 |
| ▸ | PARP1 | P09874 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 6/20 | 0.54 |
| ▸ | RAB9A | P51151 | 6/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.51 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.51 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | XBP1 | P17861 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10897886 | 0.84 | CES2 (0.67) | CES2CES1PARP1NPC1RAB9A | |
| SCHEMBL20565616 | 0.81 | ALDH1A1 (0.46) | CES2CES1PARP1NPC1RAB9A | |
| SCHEMBL24081297 | 0.81 | CES2 (0.62) | CES2CES1PARP1NPC1RAB9A | |
| SCHEMBL12045722 | 0.81 | KMT2A (0.53) | KMT2APRSS1MAPK1MAOB | |
| SCHEMBL12045718 | 0.81 | NR4A2 (0.45) | CES2CES1NPC1RAB9AKMT2A | |
| SCHEMBL31599171 | 0.80 | L3MBTL1 (0.46) | CES2CES1PARP1TSHRALDH1A1 | |
| SCHEMBL31599174 | 0.79 | PARP10 (0.58) | NPC1RAB9ANPSR1PKMKDM4E | |
| SCHEMBL2156482 | 0.79 | CES2 (1.00) | CES2CES1PARP1NPC1RAB9A | |
| SCHEMBL31414638 | 0.79 | CES2 (0.77) | CES2CES1PARP1NPC1RAB9A | |
| SCHEMBL4823687 | 0.79 | CES2 (0.77) | CES2CES1PARP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220127215-A1 | A COPPER-CATALYZED METHOD AND APPLICATION FOR PREPARING ALDEHYDES OR KETONES BY OXIDIZING ALCOHOLS WITH OXYGEN AS AN OXIDANT | FUDAN UNIVERSITY (CN) | 2022-04-28 | — | — | US | disclosed |
| EP-3943487-A1 | TRPM8 RECEPTOR AGONIST COMPOUNDS AND USES THEREOF | Universidad Miguel Hernández de Elche (ES) | 2022-01-26 | — | — | EP | disclosed |
| CN-113735868-A | Synthesis method of pyrano [3,2-b ] indole-2-ketone compound | 西北工业大学 | 2021-12-03 | — | — | CN | disclosed |
| EP-3406600-B1 | TRPM8 RECEPTOR AGONIST COMPOUNDS AND USES THEREOF | UNIV MIGUEL HERNANDEZ DE ELCHE (ES) | 2021-03-31 | — | — | EP | disclosed |
| US-10905679-B2 | TRPM8 receptor agonist compounds and uses thereof | UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE (ES) | 2021-02-02 | — | — | US | disclosed |
| WO-2020156238-A1 | COPPER-CATALYZED METHOD FOR PREPARING ALDEHYDE OR KETONE COMPOUND BY OXIDIZING ALCOHOL BY USING OXYGEN AS OXIDANT, AND APPLICATION THEREOF | 复旦大学 | 2020-08-06 | — | — | WO | disclosed |
| US-20190022068-A1 | TRPM8 RECEPTOR AGONIST COMPOUNDS AND USES THEREOF | UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE (ES) | 2019-01-24 | — | — | US | disclosed |
| EP-3406600-A1 | TRPM8 RECEPTOR AGONIST COMPOUNDS AND USES THEREOF | Universidad Miguel Hernandez De Elche (ES) | 2018-11-28 | — | — | EP | disclosed |
| EP-2942345-B1 | 3,4,5-TRIMETHOXYSTYRYLARYLAMINOPROPENONES FOR THE TREATMENT OF CANCER | COUNCIL SCIENT IND RES (IN) | 2018-03-28 | — | — | EP | disclosed |
| US-9487482-B2 | 3,4,5-trimethoxystyrylarylaminopropenones as potential anticancer agents | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2016-11-08 | — | — | US | disclosed |
| US-9487482-B2 | 3,4,5-trimethoxystyrylarylaminopropenones as potential anticancer agents | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2016-11-08 | — | — | US | disclosed |
| US-20150322009-A1 | NOVEL 3,4,5-TRIMETHOXYSTYRYLARYLAMINOPROPENONES AS POTENTIAL ANTICANCER AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2015-11-12 | — | — | US | disclosed |
| US-20150322009-A1 | NOVEL 3,4,5-TRIMETHOXYSTYRYLARYLAMINOPROPENONES AS POTENTIAL ANTICANCER AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2015-11-12 | — | — | US | disclosed |
| EP-2942345-A1 | 3,4,5-TRIMETHOXYSTYRYLARYLAMINOPROPENONES for the treatment of cancer | Council of Scientific and Industrial Research (IN) | 2015-11-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190022068-A1 | TRPM8 RECEPTOR AGONIST COMPOUNDS AND USES THEREOF | TRPM8, TRPM7, TRPM5 | CES2 2330/4885CES1 2191/4885PARP1 4310/4885 |
| US-10905679-B2 | TRPM8 receptor agonist compounds and uses thereof | TRPM8, TRPM7, TRPM5 | CES2 2330/4885CES1 2191/4885PARP1 4310/4885 |
| US-20220127215-A1 | A COPPER-CATALYZED METHOD AND APPLICATION FOR PREPARING ALDEHYDES OR KETONES BY OXIDIZING ALCOHOLS WITH OXYGEN AS AN OXIDANT | SOD1, ALDH2, AOC2 | CES2 127/4885CES1 764/4885PARP1 3642/4885 |
| US-20150322009-A1 | NOVEL 3,4,5-TRIMETHOXYSTYRYLARYLAMINOPROPENONES AS POTENTIAL ANTICANCER AGENTS | MCL1, HCCS, CASP3 | CES2 1126/4885CES1 596/4885PARP1 491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.