Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | CA12 | O43570 | 1/20 | 0.61 |
| ▸ | CA1 | P00915 | 1/20 | 0.61 |
| ▸ | CA2 | P00918 | 1/20 | 0.61 |
| ▸ | CA4 | P22748 | 1/20 | 0.61 |
| ▸ | CA6 | P23280 | 1/20 | 0.61 |
| ▸ | CA7 | P43166 | 1/20 | 0.61 |
| ▸ | TPMT | P51580 | 1/20 | 0.61 |
| ▸ | CA9 | Q16790 | 1/20 | 0.61 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17237287 | 0.86 | TUBB4A (0.55) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL17244292 | 0.84 | ALDH1A1 (0.67) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL17244290 | 0.84 | HTT (0.65) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL17244289 | 0.84 | TAS1R3 (0.48) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL30413049 | 0.81 | CYP1A2 (0.63) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2124800 | 0.81 | TSHR (0.63) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL976684 | 0.81 | CYP1A2 (0.63) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4797626 | 0.79 | TUBB4A (0.50) | TSHRCYP3A4TPMTALDH1A1GAA | |
| SCHEMBL17236952 | 0.79 | ALDH1A1 (0.56) | TSHRCYP3A4ALDH1A1MAPTPOLB | |
| SCHEMBL27768829 | 0.79 | TSHR (0.59) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3943487-A1 | TRPM8 RECEPTOR AGONIST COMPOUNDS AND USES THEREOF | Universidad Miguel Hernández de Elche (ES) | 2022-01-26 | — | — | EP | disclosed |
| CN-112300157-B | Novel pyrazolopyridine compound with anti-tumor activity and preparation method thereof | 烟台大学 | 2021-08-20 | — | — | CN | disclosed |
| US-20210188763-A1 | COMPOUNDS AND METHODS FOR HEMATOPOIETIC REGENERATION | UNIV CALIFORNIA (US) | 2021-06-24 | — | — | US | disclosed |
| EP-3406600-B1 | TRPM8 RECEPTOR AGONIST COMPOUNDS AND USES THEREOF | UNIV MIGUEL HERNANDEZ DE ELCHE (ES) | 2021-03-31 | — | — | EP | disclosed |
| CN-112300157-A | Novel pyrazolopyridine compound with anti-tumor activity and preparation method thereof | 烟台大学 | 2021-02-02 | — | — | CN | disclosed |
| US-10905679-B2 | TRPM8 receptor agonist compounds and uses thereof | UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE (ES) | 2021-02-02 | — | — | US | disclosed |
| US-10383831-B2 | 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use | Temple University—Of the Commonwealth System of Higher Education (US) | 2019-08-20 | — | — | US | disclosed |
| US-20190022068-A1 | TRPM8 RECEPTOR AGONIST COMPOUNDS AND USES THEREOF | UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE (ES) | 2019-01-24 | — | — | US | disclosed |
| EP-3406600-A1 | TRPM8 RECEPTOR AGONIST COMPOUNDS AND USES THEREOF | Universidad Miguel Hernandez De Elche (ES) | 2018-11-28 | — | — | EP | disclosed |
| US-20180243239-A1 | 2,4,6-TRIALKOXYSTRYL ARYL SULFONES, SULFONAMIDES AND CARBOXAMIDES, AND METHODS OF PREPARATION AND USE | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2018-08-30 | — | — | US | disclosed |
| WO-2017023912-A1 | 2,4,6-TRIALKOXYSTRYL ARYL SULFONES, SULFONAMIDES AND CARBOXAMIDES, AND METHODS OF PREPARATION AND USE | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2017-02-09 | — | — | WO | disclosed |
| US-9487482-B2 | 3,4,5-trimethoxystyrylarylaminopropenones as potential anticancer agents | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2016-11-08 | — | — | US | disclosed |
| US-9487482-B2 | 3,4,5-trimethoxystyrylarylaminopropenones as potential anticancer agents | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2016-11-08 | — | — | US | disclosed |
| US-20150322009-A1 | NOVEL 3,4,5-TRIMETHOXYSTYRYLARYLAMINOPROPENONES AS POTENTIAL ANTICANCER AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2015-11-12 | — | — | US | disclosed |
| US-20150322009-A1 | NOVEL 3,4,5-TRIMETHOXYSTYRYLARYLAMINOPROPENONES AS POTENTIAL ANTICANCER AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2015-11-12 | — | — | US | disclosed |
| EP-2942345-A1 | 3,4,5-TRIMETHOXYSTYRYLARYLAMINOPROPENONES for the treatment of cancer | Council of Scientific and Industrial Research (IN) | 2015-11-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190022068-A1 | TRPM8 RECEPTOR AGONIST COMPOUNDS AND USES THEREOF | TRPM8, TRPM7, TRPM5 | TSHR 335/4885CYP1A2 1057/4885CYP3A4 1015/4885 |
| US-20210188763-A1 | COMPOUNDS AND METHODS FOR HEMATOPOIETIC REGENERATION | HGF, CXCL12, CCL11 | TSHR 4417/4885CYP1A2 3333/4885CYP3A4 4034/4885 |
| US-10905679-B2 | TRPM8 receptor agonist compounds and uses thereof | TRPM8, TRPM7, TRPM5 | TSHR 335/4885CYP1A2 1057/4885CYP3A4 1015/4885 |
| US-10383831-B2 | 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use | CCNY, STS, ARSA | TSHR 297/4885CYP1A2 606/4885CYP3A4 762/4885 |
| US-20150322009-A1 | NOVEL 3,4,5-TRIMETHOXYSTYRYLARYLAMINOPROPENONES AS POTENTIAL ANTICANCER AGENTS | MCL1, HCCS, CASP3 | TSHR 2485/4885CYP1A2 121/4885CYP3A4 29/4885 |
| US-20180243239-A1 | 2,4,6-TRIALKOXYSTRYL ARYL SULFONES, SULFONAMIDES AND CARBOXAMIDES, AND METHODS OF PREPARATION AND USE | CCNY, STS, ARSA | TSHR 297/4885CYP1A2 606/4885CYP3A4 762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.