Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21482704 | 0.88 | ALDH1A1 (0.60) | ALDH1A1MAPTGAALMNAHPGD | |
| SCHEMBL21482464 | 0.81 | ALDH1A1 (0.71) | ALDH1A1MAPTGAALMNAHPGD | |
| SCHEMBL21482459 | 0.79 | ALDH1A1 (0.68) | ALDH1A1MAPTGAALMNAHPGD | |
| SCHEMBL21482675 | 0.76 | ALDH1A1 (0.62) | ALDH1A1MAPTGAALMNAHPGD | |
| SCHEMBL11219399 | 0.75 | ALDH1A1 (0.61) | ALDH1A1MAPTGAALMNAHPGD | |
| SCHEMBL21482463 | 0.75 | ALDH1A1 (0.61) | ALDH1A1MAPTGAALMNAHPGD | |
| SCHEMBL12398233 | 0.74 | ALDH1A1 (0.63) | ALDH1A1MAPTGAALMNAHPGD | |
| SCHEMBL30882162 | 0.74 | ALDH1A1 (0.53) | ALDH1A1MAPTGAALMNAHPGD | |
| SCHEMBL30882163 | 0.74 | ALDH1A1 (0.53) | ALDH1A1MAPTGAALMNAHPGD | |
| SCHEMBL30743819 | 0.74 | ALDH1A1 (0.53) | ALDH1A1MAPTGAALMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210346371-A1 | METHODS OF USING SPLICING MODULATORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2021-11-11 | — | — | US | disclosed |
| US-20210163456-A1 | CERTAIN PLADIENOLIDE COMPOUNDS AND METHODS OF USE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2021-06-03 | — | — | US | disclosed |
| US-20200361915-A1 | SOLID STATE FORM OF PLADIENOLIDE PYRIDINE COMPOUNDS AND METHODS OF USE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2020-11-19 | — | — | US | disclosed |
| US-10745387-B2 | Crystalline form of (2S,3S,6S,7R,10R,E)-7,10-dihydroxy-3,7-dimethyl-12-oxo-2-((R,2E,4E)-6-(piridin-2-yl)hepta-2,4-dien-2-yl)oxacyclododec-4-en-6-yl-4-methylpiperazine-1-carboxylate and methods of use thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2020-08-18 | — | — | US | disclosed |
| WO-2019199667-A2 | CERTAIN PLADIENOLIDE COMPOUNDS AND METHODS OF USE | KEANEY GREGG F (US) | 2019-10-17 | — | — | WO | disclosed |
| EP-3514154-A1 | PLADIENOLIDE PYRIDINE COMPOUNDS AND METHODS OF USE | Eisai R&D Management Co., Ltd. (JP) | 2019-07-24 | — | — | EP | disclosed |
| US-20190100513-A1 | SOLID STATE FORM OF PLADIENOLIDE PYRIDINE COMPOUNDS AND METHODS OF USE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2019-04-04 | — | — | US | disclosed |
| US-9481669-B2 | Pladienolide pyridine compounds and methods of use | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-11-01 | — | — | US | disclosed |
| US-9481669-B2 | Pladienolide pyridine compounds and methods of use | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-11-01 | — | — | US | disclosed |
| US-20150329528-A1 | Pladienolide Pyridine Compounds and Methods of Use | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-11-19 | — | — | US | disclosed |
| US-20150329528-A1 | Pladienolide Pyridine Compounds and Methods of Use | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210163456-A1 | CERTAIN PLADIENOLIDE COMPOUNDS AND METHODS OF USE | PLAAT5, PLAAT3, PLAAT4 | ALDH1A1 3225/4885MAPT 4316/4885GAA 521/4885 |
| US-20150329528-A1 | Pladienolide Pyridine Compounds and Methods of Use | PRUNE1, PRDX5, PDCD11 | ALDH1A1 3281/4885MAPT 3792/4885GAA 1676/4885 |
| US-20200361915-A1 | SOLID STATE FORM OF PLADIENOLIDE PYRIDINE COMPOUNDS AND METHODS OF USE | SF3B5, SF3B1, SF3A2 | ALDH1A1 3334/4885MAPT 4293/4885GAA 2228/4885 |
| US-20190100513-A1 | SOLID STATE FORM OF PLADIENOLIDE PYRIDINE COMPOUNDS AND METHODS OF USE | SF3B5, SF3B1, SF3A2 | ALDH1A1 3334/4885MAPT 4293/4885GAA 2228/4885 |
| US-20210346371-A1 | METHODS OF USING SPLICING MODULATORS | SF3B1, RBM17, SF3B5 | ALDH1A1 3704/4885MAPT 3407/4885GAA 1974/4885 |
| US-10745387-B2 | Crystalline form of (2S,3S,6S,7R,10R,E)-7,10-dihydroxy-3,7-dimethyl-12-oxo-2-((R,2E,4E)-6-(piridin-2-yl)hepta-2,4-dien-2-yl)oxacyclododec-4-en-6-yl-4-methylpiperazine-1-carboxylate and methods of use thereof | SF3B5, SF3A2, SF3B2 | ALDH1A1 1807/4885MAPT 4621/4885GAA 3759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.