Sugi Predict

Sugi Predict / Compounds / SCHEMBL1728656

SCHEMBL1728656

SCHEMBL1728656

Fc1ccccc1OCCBr

nearest known ligand 0.58

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 6/20 0.58
▸ TDP1 Q9NUW8 2/20 0.58
▸ KDM4E B2RXH2 5/20 0.49
▸ KMT2A Q03164 3/20 0.49
▸ ALDH1A1 P00352 3/20 0.49
▸ MEN1 O00255 2/20 0.49
▸ CYP1A2 P05177 2/20 0.49
▸ CYP2D6 P10635 2/20 0.49
▸ CYP2C9 P11712 2/20 0.49
▸ CYP2C19 P33261 2/20 0.49
▸ RECQL P46063 1/20 0.49
▸ CYP3A4 P08684 1/20 0.49
▸ RAB9A P51151 2/20 0.45
▸ SMN1; SMN2 Q16637 2/20 0.45
▸ MAPK1 P28482 2/20 0.45
▸ TP53 P04637 1/20 0.45
▸ TTR P02766 1/20 0.45
▸ MAPT P10636 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31596115 1.00 L3MBTL1 (0.58) L3MBTL1TDP1KDM4EKMT2AALDH1A1
SCHEMBL29824548 0.89 L3MBTL1 (0.61) L3MBTL1TDP1KDM4EKMT2AALDH1A1
SCHEMBL3074417 0.89 L3MBTL1 (0.61) L3MBTL1TDP1KDM4EKMT2AALDH1A1
SCHEMBL1282346 0.88 L3MBTL1 (0.65) L3MBTL1TDP1KDM4EKMT2AALDH1A1
SCHEMBL3235716 0.86 L3MBTL1 (0.62) L3MBTL1TDP1KDM4EKMT2AALDH1A1
SCHEMBL15922778 0.86 L3MBTL1 (0.62) L3MBTL1TDP1KDM4EKMT2AALDH1A1
SCHEMBL29755815 0.84 KDM4E (0.54) L3MBTL1TDP1KDM4EALDH1A1CYP1A2
SCHEMBL6795825 0.84 KDM4E (0.54) L3MBTL1TDP1KDM4EALDH1A1CYP1A2
SCHEMBL5706786 0.83 GRM2 (0.42) L3MBTL1TDP1KDM4EKMT2AALDH1A1
SCHEMBL7101264 0.82 L3MBTL1 (0.52) L3MBTL1TDP1KDM4EKMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117105872-A Benzodiazepine compound and preparation method and application thereof 徐州医科大学 2023-11-24 — — CN claimed
EP-3233077-B1 DOPAMINE D2 RECEPTOR LIGANDS BROAD INST INC (US) 2026-05-06 — — EP disclosed
US-12428373-B2 Dopamine D2 receptor ligands THE BROAD INSTITUTE, INC. (US) 2025-09-30 — — US disclosed
US-12144816-B2 Substituted indole Mcl-1 inhibitors VANDERBILT UNIVERSITY (US) 2024-11-19 — — US disclosed
EP-4292662-A2 SUBSTITUTED INDOLE MCL-1 INHIBITORS Vanderbilt University (US) 2023-12-20 — — EP disclosed
CN-117105872-A Benzodiazepine compound and preparation method and application thereof 徐州医科大学 2023-11-24 — — CN disclosed
US-20230330099-A1 SUBSTITUTED INDOLE MCL-1 INHIBITORS VANDERBILT UNIVERSITY 2023-10-19 — — US disclosed
EP-3423435-B1 SUBSTITUTED INDOLE MCL-1 INHIBITORS UNIV VANDERBILT (US) 2023-08-23 — — EP disclosed
US-20230143552-A1 DOPAMINE D2 RECEPTOR LIGANDS THE BROAD INSTITUTE, INC. (US) 2023-05-11 — — US disclosed
US-20230143552-A1 DOPAMINE D2 RECEPTOR LIGANDS THE BROAD INSTITUTE, INC. (US) 2023-05-11 — — US disclosed
US-20040167216-A1 Carbidopa prodrugs and derivatives, and compositions and uses thereof XIANG JIA-NING (US) 2004-08-26 — — US disclosed
WO-2004052841-A1 CARBIDOPA PRODRUGS AND USES THEREOF XENOPORT, INC. (US) 2004-06-24 — — WO disclosed
US-20030212094-A1 Novel cyclic amide derivatives MITSUBISHI PHARMA CORPORATION (JP) 2003-11-13 — — US disclosed
CN-1426405-A Novel cyclic amide derivative MITSUBISHI PHARMACEUTICALS INC (JP) 2003-06-25 — — CN disclosed
EP-1260512-A1 NOVEL CYCLIC AMIDE DERIVATIVES Mitsubishi Pharma Corporation (JP) 2002-11-27 — — EP disclosed
EP-1140896-A1 BENZOTHIEPIN-ANILIDE DERIVATIVES, THEIR PRODUCTION AND THEIR USE FOR ANTAGONIZING CCR-5 Takeda Chemical Industries, Ltd. (JP) 2001-10-10 — — EP disclosed
WO-2000037455-A1 BENZOTHIEPIN-ANILIDE DERIVATIVES, THEIR PRODUCTION AND THEIR USE FOR ANTAGONIZING CCR-5 TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2000-06-29 — — WO disclosed
WO-1997023202-A1 SUBTYPE-SELECTIVE NMDA RECEPTOR LIGANDS AND THE USE THEREOF STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALTH SCIENCES UNIVERSITYA ND THE UNIVERSITY OF OREGON, EUGENE OREGON (US) 1997-07-03 — — WO disclosed
CN-1006794-B PROCESS FOR THE PREPARATION OF ASYMMETRIC HYDANTOINS PFIZER (US) 1990-02-14 — — CN disclosed
CN-85105869-A The preparation method of asymmetric glycolylurea — 1987-01-28 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040167216-A1 Carbidopa prodrugs and derivatives, and compositions and uses thereof PDE3A, ADORA2A, CDA L3MBTL1 2983/4885TDP1 329/4885KDM4E 3409/4885
US-20230143552-A1 DOPAMINE D2 RECEPTOR LIGANDS DRD2, SLC6A3, NTSR2 L3MBTL1 1719/4885TDP1 2036/4885KDM4E 4204/4885
US-12144816-B2 Substituted indole Mcl-1 inhibitors MCL1, BCL2L1, BCL9 L3MBTL1 135/4885TDP1 1235/4885KDM4E 1156/4885
US-12428373-B2 Dopamine D2 receptor ligands DRD2, SLC6A3, NTSR2 L3MBTL1 1719/4885TDP1 2036/4885KDM4E 4204/4885
US-20030212094-A1 Novel cyclic amide derivatives SIGMAR1, OPRM1, OPRD1 L3MBTL1 3329/4885TDP1 4666/4885KDM4E 2058/4885
US-20230330099-A1 SUBSTITUTED INDOLE MCL-1 INHIBITORS MCL1, BCL2L1, BCL9 L3MBTL1 135/4885TDP1 1235/4885KDM4E 1156/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.