Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 3/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | SMO | Q99835 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1729308 | 0.95 | HRH3 (0.44) | HRH3PDE10APDE2AHTR3AHTR3E | |
| SCHEMBL1728165 | 0.89 | KDM4E (0.45) | HRH3PDE10APDE2AHTR3AHTR3E | |
| SCHEMBL1730418 | 0.87 | HRH3 (0.45) | HRH3PDE10APDE2AHTR3AHTR3E | |
| SCHEMBL1729779 | 0.87 | SMO (0.34) | PDE10APDE2ADGAT1KCNH2ADORA2A | |
| SCHEMBL1727892 | 0.86 | HTR1A (0.39) | HRH3HTR3ASMOKDM4EALDH1A1 | |
| SCHEMBL1728927 | 0.84 | HRH3 (0.47) | HRH3KCNH2KDM4EALDH1A1ACACB | |
| SCHEMBL1729592 | 0.84 | PTGES (0.42) | PDE10APDE2ASMOHSD11B1PTGES | |
| SCHEMBL1728881 | 0.83 | HCAR2 (0.36) | PDE10AOPRK1SMOKDM4EALDH1A1 | |
| SCHEMBL1727558 | 0.83 | KCNH2 (0.40) | DGAT1KCNH2ADORA2AKDM4E | |
| SCHEMBL1729453 | 0.82 | PDE10A (0.36) | PDE10AHTR3AHRH4OPRK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633735-B1 | DERIVATIVES OF PIPERIDINYL- AND PIPERAZINYL-ALKYL CARBAMATES, PREPARATION METHODS THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | SANOFI SA (FR) | 2011-11-30 | — | — | EP | claimed |