Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 4/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | CKS1B | P61024 | 4/20 | 0.32 |
| ▸ | SKP1 | P63208 | 4/20 | 0.32 |
| ▸ | SKP2 | Q13309 | 4/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 3/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1729264 | 0.89 | HTR3A (0.41) | DGAT1KCNH2CKS1BSKP1SKP2 | |
| SCHEMBL1730142 | 0.88 | ABL1 (0.37) | MAPTPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1729308 | 0.87 | HRH3 (0.44) | DGAT1KCNH2PDE2APDE10AF10 | |
| SCHEMBL1729370 | 0.87 | HRH3 (0.43) | SMODGAT1KCNH2ADORA2AKDM4E | |
| SCHEMBL1728140 | 0.84 | ABL1 (0.35) | DEGS1TRPV1 | |
| SCHEMBL1727558 | 0.84 | KCNH2 (0.40) | DGAT1KCNH2ADORA2ADEGS1KDM4E | |
| SCHEMBL1729453 | 0.82 | PDE10A (0.36) | KDM4EMAPTPDE10AF10F2 | |
| SCHEMBL1730195 | 0.79 | HCAR2 (0.46) | MAPTCKS1BSKP1SKP2 | |
| SCHEMBL1729592 | 0.78 | PTGES (0.42) | SMOPDE2APDE10APDE4APDE4B | |
| SCHEMBL1727921 | 0.78 | KDM4E (0.43) | DRD2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633735-B1 | DERIVATIVES OF PIPERIDINYL- AND PIPERAZINYL-ALKYL CARBAMATES, PREPARATION METHODS THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | SANOFI SA (FR) | 2011-11-30 | — | — | EP | claimed |