Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 5/20 | 0.52 |
| ▸ | NSD2 | O96028 | 4/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.43 |
| ▸ | RBP4 | P02753 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1728967 | 0.91 | NSD2 (0.47) | CHRM4NSD2P2RX7HTR1ADRD2 | |
| SCHEMBL1727773 | 0.88 | P2RX7 (0.54) | P2RX7HTR1ADRD2HTR7HTR6 | |
| SCHEMBL3265672 | 0.85 | CHRM4 (0.45) | CHRM4NSD2P2RX7HTR1ADRD2 | |
| SCHEMBL1730203 | 0.84 | CHRM4 (0.51) | CHRM4NSD2SIRT2SIRT1SIRT3 | |
| SCHEMBL1727887 | 0.83 | KDM4E (0.60) | CHRM4DRD2MALT1 | |
| SCHEMBL1728813 | 0.81 | SIRT2 (0.51) | CHRM4DRD2SIRT2SIRT1SIRT3 | |
| SCHEMBL1727778 | 0.80 | P2RX7 (0.53) | P2RX7HTR1ADRD2HTR7HTR6 | |
| SCHEMBL1727561 | 0.80 | KMT2A (0.48) | P2RX7MALT1 | |
| SCHEMBL1727741 | 0.80 | CHRM4 (0.56) | CHRM4DRD2 | |
| SCHEMBL1729606 | 0.77 | CHRM4 (0.57) | CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633735-B1 | DERIVATIVES OF PIPERIDINYL- AND PIPERAZINYL-ALKYL CARBAMATES, PREPARATION METHODS THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | SANOFI SA (FR) | 2011-11-30 | — | — | EP | claimed |