Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | RORB | Q92753 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL165773 | 0.83 | ADORA3 (0.61) | SMN1; SMN2LMNANPSR1HTTMAPT | |
| SCHEMBL257432 | 0.81 | RORB (0.74) | LMNANPSR1RORBALDH1A1HSD17B10 | |
| SCHEMBL19669120 | 0.81 | ALDH1A1 (0.72) | SMN1; SMN2MAPTALDH1A1HSD17B10POLB | |
| SCHEMBL175512 | 0.79 | RORB (0.54) | RORBALDH1A1HSD17B10ADORA3ADORA1 | |
| SCHEMBL169403 | 0.78 | RORC (0.58) | SMN1; SMN2LMNANPSR1HTTMAPT | |
| SCHEMBL10092883 | 0.77 | RORB (0.67) | RORBALDH1A1HSD17B10ADORA3ADORA1 | |
| SCHEMBL27653923 | 0.76 | ALDH1A1 (0.64) | SMN1; SMN2NPSR1HTTMAPTRORB | |
| SCHEMBL257615 | 0.75 | RORB (0.72) | RORBALDH1A1 | |
| SCHEMBL14364298 | 0.75 | KDM4E (0.54) | SMN1; SMN2LMNAMAPTALDH1A1HSD17B10 | |
| SCHEMBL175193 | 0.75 | ALDH1A1 (0.52) | SMN1; SMN2LMNANPSR1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027965-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012027965-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | WO | disclosed |