Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORB | Q92753 | 8/20 | 0.54 |
| ▸ | RORC | P51449 | 1/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL174906 | 0.84 | RORB (0.74) | RORBRORCADORA2AADORA1 | |
| SCHEMBL165773 | 0.83 | ADORA3 (0.61) | RORBADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL257432 | 0.81 | RORB (0.74) | RORBRORCADORA2AADORA1ADORA3 | |
| SCHEMBL175591 | 0.81 | RORC (0.47) | RORBRORCADORA2AADORA1ADORA3 | |
| SCHEMBL174332 | 0.79 | SMN1; SMN2 (0.54) | RORBADORA1ADORA3ADORA2BALDH1A1 | |
| SCHEMBL6288104 | 0.78 | ALDH1A1 (0.69) | ADORA2AALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL1256197 | 0.77 | ADORA2A (0.49) | ADORA2AADORA1ADORA3ALDH1A1HSD17B10 | |
| SCHEMBL10092883 | 0.77 | RORB (0.67) | RORBRORCADORA2AADORA1ADORA3 | |
| SCHEMBL169403 | 0.76 | RORC (0.58) | RORBRORCADORA2AADORA1ADORA3 | |
| SCHEMBL27653923 | 0.76 | ALDH1A1 (0.64) | RORBRORCADORA3ADORA2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027965-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012027965-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | WO | disclosed |