4-Aminophenol

4-Aminophenol

SCHEMBL17436623

Nc1ccc(O)cc1.Nc1ccc(O)cc1.O=S(=O)(O)O

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of 4-Aminophenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.72
CYP3A4 P08684 5/20 0.72
ALOX15 P16050 4/20 0.72
HSD17B10 Q99714 4/20 0.72
THRB P10828 3/20 0.72
CASP1 P29466 3/20 0.72
HIF1A Q16665 3/20 0.72
CA14 Q9ULX7 3/20 0.72
CA6 P23280 2/20 0.72
CA3 P07451 2/20 0.72
TSHR P16473 4/20 0.56
NT5E P21589 1/20 0.56
APP P05067 3/20 0.54
LMNA P02545 3/20 0.52
CA1 P00915 5/20 0.50
CA2 P00918 5/20 0.50
HPGD P15428 3/20 0.50
RECQL P46063 3/20 0.50
CA12 O43570 3/20 0.50
CA9 Q16790 3/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
4-Aminophenol SCHEMBL1028523 1.00 ALDH1A1 (0.72) ALDH1A1CYP3A4ALOX15HSD17B10THRB
4-Aminophenol SCHEMBL27327366 0.92 ALDH1A1 (0.68) ALDH1A1CYP3A4ALOX15HSD17B10THRB
Sulfuric Acid SCHEMBL147074 0.88 TSHR (0.68) ALDH1A1CYP3A4ALOX15HSD17B10THRB
Sulfuric Acid SCHEMBL28572498 0.88 TSHR (0.68) ALDH1A1CYP3A4ALOX15HSD17B10THRB
Sulfuric Acid SCHEMBL28270834 0.88 TSHR (0.68) ALDH1A1CYP3A4ALOX15HSD17B10THRB
4-Aminophenol SCHEMBL22462461 0.86 ALDH1A1 (0.68) ALDH1A1CYP3A4ALOX15HSD17B10THRB
Hydroquinone SCHEMBL9458925 0.85 TSHR (0.82) ALDH1A1CYP3A4ALOX15HSD17B10THRB
Sulfuric Acid SCHEMBL28964013 0.85 TSHR (0.65) ALDH1A1CYP3A4ALOX15HSD17B10THRB
Sulfuric Acid SCHEMBL1599590 0.85 TSHR (0.65) ALDH1A1CYP3A4ALOX15HSD17B10THRB
Sulfuric Acid SCHEMBL27972059 0.85 TSHR (0.65) ALDH1A1CYP3A4ALOX15HSD17B10THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210145716-A9 COMPOSITION FOR HAIR FRIZZ REDUCTION THE PROCTER & GAMBLE COMPANY 2021-05-20 US claimed
US-10980723-B2 Non-aqueous composition for hair frizz reduction THE PROCTER AND GAMBLE COMPANY (US) 2021-04-20 US claimed
US-10632054-B2 Method for hair frizz reduction THE PROCTER AND GAMBLE COMPANY (US) 2020-04-28 US claimed
US-10111820-B2 Composition for hair frizz reduction THE PROCTER AND GAMBLE COMPANY (US) 2018-10-30 US claimed
US-20180289603-A1 NON-AQUEOUS COMPOSITION FOR HAIR FRIZZ REDUCTION THE PROCTER & GAMBLE COMPANY 2018-10-11 US claimed
WO-2017096153-A1 COMPOSITION FOR HAIR FRIZZ REDUCTION THE PROCTER & GAMBLE COMPANY (US) 2017-06-08 WO claimed
US-20170157011-A1 HAIR CARE REGIMEN USING COMPOSITIONS COMPRISING MOISTURE CONTROL MATERIALS THE PROCTER & GAMBLE COMPANY 2017-06-08 US claimed
US-20170157008-A1 COMPOSITION FOR HAIR FRIZZ REDUCTION PROCTER & GAMBLE (US) 2017-06-08 US claimed
WO-2017096154-A1 HAIR CARE REGIMEN USING COMPOSITIONS COMPRISING MOISTURE CONTROL MATERIALS THE PROCTER & GAMBLE COMPANY (US) 2017-06-08 WO claimed
US-20160287495-A1 Method for Hair Frizz Reduction THE PROCTER & GAMBLE COMPANY 2016-10-06 US claimed
US-20160158135-A1 COMPOSITION FOR HAIR FRIZZ REDUCTION THE PROCTER & GAMBLE COMPANY 2016-06-09 US claimed
US-20160015608-A1 COMPOSITION FOR HAIR FRIZZ REDUCTION THE PROCTER & GAMBLE COMPANY 2016-01-21 US claimed
EP-4162982-A2 COMPOSITION FOR HAIR FRIZZ REDUCTION The Procter & Gamble Company (US) 2023-04-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210145716-A9 COMPOSITION FOR HAIR FRIZZ REDUCTION GK, YWHAZ, GRK2 ALDH1A1 2886/4885CYP3A4 4644/4885ALOX15 586/4885
US-20170157008-A1 COMPOSITION FOR HAIR FRIZZ REDUCTION GK, YWHAZ, GRK2 ALDH1A1 2886/4885CYP3A4 4644/4885ALOX15 586/4885
US-20160287495-A1 Method for Hair Frizz Reduction GK, GRK2, GRK3 ALDH1A1 2735/4885CYP3A4 4654/4885ALOX15 1083/4885
US-20180289603-A1 NON-AQUEOUS COMPOSITION FOR HAIR FRIZZ REDUCTION CROCC, YWHAZ, SHH ALDH1A1 3734/4885CYP3A4 4570/4885ALOX15 1688/4885
US-20160158135-A1 COMPOSITION FOR HAIR FRIZZ REDUCTION YWHAZ, GK, GRK3 ALDH1A1 2828/4885CYP3A4 4646/4885ALOX15 1627/4885
US-10111820-B2 Composition for hair frizz reduction YWHAZ, GK, GRK3 ALDH1A1 2828/4885CYP3A4 4646/4885ALOX15 1627/4885
US-10980723-B2 Non-aqueous composition for hair frizz reduction SHH, FZD7, SFRP1 ALDH1A1 4339/4885CYP3A4 4678/4885ALOX15 3052/4885
US-10632054-B2 Method for hair frizz reduction GK, GRK2, GRK3 ALDH1A1 2735/4885CYP3A4 4654/4885ALOX15 1083/4885
US-20160015608-A1 COMPOSITION FOR HAIR FRIZZ REDUCTION CROCC, GK, YWHAZ ALDH1A1 3328/4885CYP3A4 4637/4885ALOX15 1674/4885
US-20170157011-A1 HAIR CARE REGIMEN USING COMPOSITIONS COMPRISING MOISTURE CONTROL MATERIALS MSH6, POLR1C, MSH2 ALDH1A1 757/4885CYP3A4 3504/4885ALOX15 3091/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.