Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26417660 | 0.91 | ELANE (0.59) | ELANELMNAALDH1A1HTR2A | |
| SCHEMBL8033783 | 0.87 | ALDH1A1 (0.62) | ELANELMNAALDH1A1POLBMAPT | |
| SCHEMBL24983721 | 0.87 | ALDH1A1 (0.62) | LMNAALDH1A1POLBKMT2A | |
| SCHEMBL15762727 | 0.87 | ALDH1A1 (0.48) | ELANELMNAALDH1A1POLBKMT2A | |
| SCHEMBL6666839 | 0.85 | LMNA (0.53) | ELANELMNAALDH1A1POLBMAPT | |
| SCHEMBL20467620 | 0.85 | ESR1 (0.53) | ELANELMNAHTR2AKMT2AESR1 | |
| SCHEMBL4456075 | 0.84 | ALDH1A1 (0.55) | ALDH1A1POLBMAPT | |
| SCHEMBL23417721 | 0.82 | TOP2A (0.55) | ELANELMNAALDH1A1 | |
| SCHEMBL12526433 | 0.82 | LMNA (0.50) | ELANELMNAALDH1A1POLBMAPT | |
| SCHEMBL4032287 | 0.82 | ALDH1A1 (0.56) | ELANELMNAALDH1A1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239774-A1 | SOLUBLE ADENYLYL CYCLASE (SAC) INHIBITORS AND USES THEREOF | CORNELL UNIVERSITY (US) | 2024-07-18 | — | — | US | disclosed |
| US-20240239774-A1 | SOLUBLE ADENYLYL CYCLASE (SAC) INHIBITORS AND USES THEREOF | CORNELL UNIVERSITY (US) | 2024-07-18 | — | — | US | disclosed |
| US-11370801-B2 | Pyrrolobenzodiazepine conjugates | MEDIMMUNE LIMITED (GB) | 2022-06-28 | — | — | US | disclosed |
| US-20220160881-A1 | AZETIDOBENZODIAZEPINE DIMERS AND CONJUGATES COMPRISING THEM FOR USE IN THE TREATMENT OF CANCER | MEDIMMUNE LIMITED (GB) | 2022-05-26 | — | — | US | disclosed |
| US-20210380605-A1 | PYRROLOBENZODIAZEPINE CONJUGATES | MEDIMMUNE LIMITED (GB) | 2021-12-09 | — | — | US | disclosed |
| US-20210316006-A1 | PYRROLOBENZODIAZEPINE CONJUGATES | MEDIMMUNE LIMITED (GB) | 2021-10-14 | — | — | US | disclosed |
| US-20200115390-A1 | PYRROLOBENZODIAZEPINE CONJUGATES | MEDIMMUNE LIMITED (GB) | 2020-04-16 | — | — | US | disclosed |
| US-10188746-B2 | Pyrrolobenzodiazepines and conjugates thereof | MEDIMMUNE LIMITED (GB) | 2019-01-29 | — | — | US | disclosed |
| EP-2968585-B1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | MEDIMMUNE LTD (GB) | 2018-07-18 | — | — | EP | disclosed |
| US-20170340752-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | MEDIMMUNE LIMITED (GB) | 2017-11-30 | — | — | US | disclosed |
| US-20160031887-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | SPIROGEN LIMITED (GB) | 2016-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239774-A1 | SOLUBLE ADENYLYL CYCLASE (SAC) INHIBITORS AND USES THEREOF | UACA, ADCYAP1R1, ADCY1 | ELANE 4174/4885LMNA 3019/4885ALDH1A1 638/4885 |
| US-11370801-B2 | Pyrrolobenzodiazepine conjugates | NR0B2, HRH3, NR0B1 | ELANE 3484/4885LMNA 2492/4885ALDH1A1 1745/4885 |
| US-20210316006-A1 | PYRROLOBENZODIAZEPINE CONJUGATES | BCR, MCL1, CD79B | ELANE 4390/4885LMNA 2504/4885ALDH1A1 737/4885 |
| US-20200115390-A1 | PYRROLOBENZODIAZEPINE CONJUGATES | NR0B2, HRH3, NR0B1 | ELANE 3484/4885LMNA 2492/4885ALDH1A1 1745/4885 |
| US-20220160881-A1 | AZETIDOBENZODIAZEPINE DIMERS AND CONJUGATES COMPRISING THEM FOR USE IN THE TREATMENT OF CANCER | BCR, UGT2B17, BCL6B | ELANE 4465/4885LMNA 3174/4885ALDH1A1 692/4885 |
| US-10188746-B2 | Pyrrolobenzodiazepines and conjugates thereof | CD22, GABRA1, CCNB1 | ELANE 1809/4885LMNA 983/4885ALDH1A1 1275/4885 |
| US-20160031887-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | GABRA3, GABRA4, AVPR1B | ELANE 3733/4885LMNA 2301/4885ALDH1A1 450/4885 |
| US-20210380605-A1 | PYRROLOBENZODIAZEPINE CONJUGATES | PRLHR, GLRA1, CXCR1 | ELANE 4471/4885LMNA 1267/4885ALDH1A1 1373/4885 |
| US-20170340752-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | CD22, GABRA1, CCNB1 | ELANE 1809/4885LMNA 983/4885ALDH1A1 1275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.