SCHEMBL1753533

SCHEMBL1753533

Cc1ccc([C@@H](O)[C@@H](CO)NC(=O)C(Cl)Cl)cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 5/20 0.70
TSHR P16473 2/20 0.70
SMN1; SMN2 Q16637 4/20 0.66
CYP3A4 P08684 3/20 0.66
ALDH1A1 P00352 3/20 0.66
MARS2 Q96GW9 1/20 0.66
CYP2C19 P33261 1/20 0.66
RPLP1 P05386 1/20 0.60
RPLP0 P05388 1/20 0.60
RPS17 P08708 1/20 0.60
RPSA P08865 1/20 0.60
RPS2 P15880 1/20 0.60
RPL35A P18077 1/20 0.60
RPL7 P18124 1/20 0.60
RPL17 P18621 1/20 0.60
RPS4Y1 P22090 1/20 0.60
RPS3 P23396 1/20 0.60
RPS12 P25398 1/20 0.60
RPL13 P26373 1/20 0.60
RPL10 P27635 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12413849 0.86 LMNA (0.71) LMNATSHRSMN1; SMN2CYP3A4ALDH1A1
Cetophenicol SCHEMBL192096 0.85 LMNA (0.67) LMNATSHRSMN1; SMN2CYP3A4ALDH1A1
Cetophenicol SCHEMBL192097 0.85 LMNA (0.67) LMNATSHRSMN1; SMN2CYP3A4ALDH1A1
SCHEMBL29651721 0.84 LMNA (0.66) LMNATSHRSMN1; SMN2CYP3A4ALDH1A1
SCHEMBL10777805 0.84 LMNA (0.66) LMNATSHRSMN1; SMN2CYP3A4ALDH1A1
SCHEMBL9836784 0.84 ALDH1A1 (0.65) LMNATSHRSMN1; SMN2CYP3A4ALDH1A1
SCHEMBL8896382 0.84 LMNA (0.65) LMNATSHRSMN1; SMN2CYP3A4ALDH1A1
SCHEMBL8370097 0.84 LMNA (0.65) LMNATSHRSMN1; SMN2CYP3A4ALDH1A1
SCHEMBL15482182 0.84 LMNA (0.51) LMNATSHRSMN1; SMN2CYP3A4ALDH1A1
Thiamphenicol SCHEMBL34635 0.82 LMNA (1.00) LMNATSHRSMN1; SMN2CYP3A4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8232265-B2 Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) 2012-07-31 US disclosed
US-8158372-B2 Agonists of a bitter taste receptor and uses thereof DEUTSCHES INSTITUT FÜR ERNÄHRUNGSFORSCHUNG POTSDAM-REHBRÜCKE (DE) 2012-04-17 US disclosed
US-20110166359-A1 PROCESS FOR PREPARING OXAZOLINE-PROTECTED AMINODIOL COMPOUNDS USEFUL AS INTERMEDIATES TO FLORFENICOL INTERVET INTERNATIONAL B.V. (NL) 2011-07-07 US disclosed
US-20070093462-A1 Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA 2007-04-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070093462-A1 Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients SLC5A6, PNLIP, IPMK LMNA 1556/4885TSHR 4253/4885SMN1; SMN2 742/4885
US-20110166359-A1 PROCESS FOR PREPARING OXAZOLINE-PROTECTED AMINODIOL COMPOUNDS USEFUL AS INTERMEDIATES TO FLORFENICOL PFAS, DHFR, OXA1L LMNA 1876/4885TSHR 4330/4885SMN1; SMN2 1703/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.