Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17595084 | 0.84 | PARP1 (0.36) | PARP1PARP2 | |
| SCHEMBL17594871 | 0.79 | ALDH1A1 (0.39) | PARP1PARP2SIRT2SIRT1 | |
| SCHEMBL17594971 | 0.78 | LMNA (0.39) | PARP1PARP2SIRT2SIRT1 | |
| SCHEMBL14740870 | 0.74 | PARP1 (0.39) | PARP1PARP2 | |
| SCHEMBL17594868 | 0.69 | KIF11 (0.38) | PARP1PARP2SIRT2SIRT1 | |
| SCHEMBL14745803 | 0.68 | DCTPP1 (0.40) | PARP1PARP2SIRT2SIRT1 | |
| SCHEMBL17594969 | 0.68 | KIF11 (0.39) | PARP1PARP2SIRT2SIRT1 | |
| SCHEMBL17595142 | 0.68 | ABCB1 (0.39) | — | |
| SCHEMBL14740829 | 0.67 | SLC16A3 (0.45) | PARP1PARP2SIRT2SIRT1 | |
| SCHEMBL17595256 | 0.67 | PDE3B (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016039936-A2 | MONOCYCLIC SUBSTITUTED 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | claimed |