Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 5/20 | 0.35 |
| ▸ | FABP5 | Q01469 | 5/20 | 0.35 |
| ▸ | RORC | P51449 | 5/20 | 0.35 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17613353 | 0.91 | FABP4 (0.38) | SMN1; SMN2FABP4FABP5 | |
| SCHEMBL17599375 | 0.80 | ACLY (0.49) | KDM4EKEAP1GLO1MMP2MMP9 | |
| SCHEMBL17599385 | 0.76 | TSHR (0.47) | SMN1; SMN2FABP4FABP5SLC16A3KMT2A | |
| SCHEMBL17599320 | 0.74 | SMN1; SMN2 (0.54) | KDM4ETDP1HTTSMN1; SMN2FABP4 | |
| SCHEMBL17599357 | 0.73 | KDM4E (0.46) | KDM4EGLO1MMP2MMP9SLC40A1 | |
| SCHEMBL17599338 | 0.73 | FABP4 (0.42) | SMN1; SMN2FABP4FABP5SLC16A3 | |
| SCHEMBL17612856 | 0.72 | KEAP1 (0.56) | KDM4EKEAP1ALDH1A1GAAHTT | |
| SCHEMBL17599305 | 0.72 | ACLY (0.55) | SMN1; SMN2FABP4FABP5SLC16A3 | |
| SCHEMBL17599334 | 0.71 | PFKFB4 (0.41) | KDM4EGLO1MMP2MMP9SLC40A1 | |
| SCHEMBL17599377 | 0.71 | PFKFB3 (0.56) | KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |