Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 7/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5694221 | 0.76 | RAPGEF4 (0.45) | RAPGEF4NPSR1MAPK1MAPTHTT | |
| SCHEMBL1976805 | 0.74 | CA1 (0.50) | RAPGEF4NPSR1MAPTHTTGAA | |
| SCHEMBL5396539 | 0.72 | GRM4 (0.44) | MAPTGAAALDH1A1MMP2MEN1 | |
| SCHEMBL9498378 | 0.71 | FABP4 (0.57) | TDP1GAAPIK3CDPIK3CAPIK3CB | |
| SCHEMBL10587124 | 0.70 | TSHR (0.48) | MAPTGAAALDH1A1POLBPKM | |
| SCHEMBL2386706 | 0.69 | RAPGEF4 (0.45) | RAPGEF4NPSR1MAPK1MAPTHTT | |
| SCHEMBL841998 | 0.69 | TSHR (0.58) | RAPGEF4NPSR1MAPK1HTTMEN1 | |
| SCHEMBL9705778 | 0.67 | ALDH1A1 (0.39) | RAPGEF4MAPK1GAAALDH1A1POLB | |
| SCHEMBL4947198 | 0.66 | — | — | |
| SCHEMBL1763261 | 0.66 | ALDH1A1 (0.49) | RAPGEF4NPSR1MAPK1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9567364-B2 | Nucleotide and/or oligonucleotide and preparation process thereof | Suzhou Ribo Life Sciene Co., Ltd. (CN) | 2017-02-14 | — | — | US | claimed |
| EP-2599784-B1 | NUCLEOTIDE AND/OR OLIGONUCLEOTIDE AND PREPARATION PROCESS THEREOF | SUZHOU RIBO LIFE SCIENCE CO LTD (CN) | 2016-06-29 | — | — | EP | claimed |
| US-8614312-B2 | Method for preparing nucleotides and related analogues by synthesis on soluble substrate, and biological tools thus prepared | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2013-12-24 | — | — | US | claimed |
| EP-2599784-A1 | NUCLEOTIDE AND/OR OLIGONUCLEOTIDE AND PREPARATION PROCESS THEREOF | Suzhou Ribo Life Science Co., Ltd (CN) | 2013-06-05 | — | — | EP | claimed |
| US-20130123482-A1 | NUCLEOTIDE AND/OR OLIGONUCLEOTIDE AND PREPARATION PROCESS THEREOF | SUZHOU RIBO LIFE SCIENCE CO., LTD (CN) | 2013-05-16 | — | — | US | claimed |
| US-20110118454-A1 | METHOD FOR PREPARING NUCLEOTIDES AND RELATED ANALOGUES BY SYNTHESIS ON SOLUBLE SUBSTRATE, AND BIOLOGICAL TOOLS THUS PREPARED | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-05-19 | — | — | US | claimed |
| EP-0611999-B1 | Reusable positive-charging organic photoconductor containing phthalocyanine pigment and cross-linking binder | HEWLETT PACKARD CO (US) | 1999-04-14 | — | — | EP | claimed |
| JP-57088196-A | — | — | None | — | — | JP | disclosed |
| US-9567364-B2 | Nucleotide and/or oligonucleotide and preparation process thereof | Suzhou Ribo Life Sciene Co., Ltd. (CN) | 2017-02-14 | — | — | US | disclosed |
| EP-2599784-B1 | NUCLEOTIDE AND/OR OLIGONUCLEOTIDE AND PREPARATION PROCESS THEREOF | SUZHOU RIBO LIFE SCIENCE CO LTD (CN) | 2016-06-29 | — | — | EP | disclosed |
| US-8614312-B2 | Method for preparing nucleotides and related analogues by synthesis on soluble substrate, and biological tools thus prepared | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2013-12-24 | — | — | US | disclosed |
| EP-2599784-A1 | NUCLEOTIDE AND/OR OLIGONUCLEOTIDE AND PREPARATION PROCESS THEREOF | Suzhou Ribo Life Science Co., Ltd (CN) | 2013-06-05 | — | — | EP | disclosed |
| US-20130123482-A1 | NUCLEOTIDE AND/OR OLIGONUCLEOTIDE AND PREPARATION PROCESS THEREOF | SUZHOU RIBO LIFE SCIENCE CO., LTD (CN) | 2013-05-16 | — | — | US | disclosed |
| US-5807837-A | ADMINISTERING TO TREAT HIV INFECTIONS TO INHIBIT THE REPLICATION OF FOREIGN NUCLEIC ACIDS IN A NORMAL CELL | SANKYO COMPANY, LIMITED (JP) | 1998-09-15 | — | — | US | disclosed |
| US-5674856-A | TREATMENT AND PROPHYLAXIS OF VIRAL INFECTIONS, INCLUDING AIDS AND TUMORS | SANKYO COMPANY, LIMITED (JP) | 1997-10-07 | — | — | US | disclosed |
| EP-0611075-B1 | Modified oligodeoxyribonucleotides, their preparation and their therapeutic use | SANKYO CO (JP) | 1996-12-18 | — | — | EP | disclosed |
| EP-0611075-A1 | Modified oligodeoxyribonucleotides, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1994-08-17 | — | — | EP | disclosed |
| EP-0331032-B1 | 2'-DEOXY-5-FLUOROURIDINE DERIVATIVES | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 1993-04-28 | — | — | EP | disclosed |
| US-5032680-A | Antitumor | KURARAY CO., LTD. (JP) | 1991-07-16 | — | — | US | disclosed |
| JP-S5788196-A | PRODUCTION OF OLIGONUCLEOTIDES | EISAI CO LTD | 1982-06-01 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130123482-A1 | NUCLEOTIDE AND/OR OLIGONUCLEOTIDE AND PREPARATION PROCESS THEREOF | RNGTT, RNMT, NUDT1 | RAPGEF4 3189/4885NPSR1 554/4885MAPK1 1037/4885 |
| US-20110118454-A1 | METHOD FOR PREPARING NUCLEOTIDES AND RELATED ANALOGUES BY SYNTHESIS ON SOLUBLE SUBSTRATE, AND BIOLOGICAL TOOLS THUS PREPARED | PNP, NUDT1, DUT | RAPGEF4 939/4885NPSR1 1621/4885MAPK1 140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.