Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | THPO | P40225 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MGLL | Q99685 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.33 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.33 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1764267 | 0.85 | MEN1 (0.38) | KMT2AMEN1LMNACYP3A4CYP2C9 | |
| SCHEMBL19172387 | 0.84 | MEN1 (0.37) | KMT2AMEN1LMNACYP3A4CYP2C9 | |
| SCHEMBL14794931 | 0.84 | MEN1 (0.33) | KMT2AMEN1LMNACYP3A4CYP2C9 | |
| SCHEMBL2193456 | 0.83 | MEN1 (0.35) | KMT2AMEN1LMNACYP3A4CYP2C9 | |
| SCHEMBL4699686 | 0.83 | TDP1 (0.35) | KMT2AMEN1LMNACYP3A4CYP2C9 | |
| SCHEMBL917125 | 0.83 | MEN1 (0.36) | KMT2AMEN1LMNACYP3A4CYP2C9 | |
| SCHEMBL19543529 | 0.83 | MAPK1 (0.37) | KMT2AMEN1LMNACYP3A4CYP2C9 | |
| SCHEMBL2147485 | 0.82 | CYP3A4 (0.35) | KMT2AMEN1LMNACYP3A4CYP2C9 | |
| SCHEMBL13108203 | 0.82 | LMNA (0.35) | KMT2AMEN1LMNACYP3A4CYP2C9 | |
| SCHEMBL12972246 | 0.82 | KMT2A (0.35) | KMT2AMEN1LMNACYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10131681-B2 | Aminophosphinic derivatives that can be used in the treatment of pain | PHARMALEADS (FR) | 2018-11-20 | — | — | US | disclosed |
| EP-2740736-B1 | Aminophosphinic derivatives suitable for use in the treatment of pain | PHARMALEADS (FR) | 2015-12-09 | — | — | EP | disclosed |
| EP-2326655-B1 | AMINOPHOSPHINIC DERIVATIVES THAT CAN BE USED IN THE TREATMENT OF PAIN | PHARMALEADS (FR) | 2014-12-31 | — | — | EP | disclosed |
| US-20140161839-A1 | AMINOPHOSPHINIC DERIVATIVES THAT CAN BE USED IN THE TREATMENT OF PAIN | PHARMALEADS (FR) | 2014-06-12 | — | — | US | disclosed |
| EP-2740736-A1 | Aminophosphinic derivatives suitable for use in the treatment of pain | Pharmaleads (FR) | 2014-06-11 | — | — | EP | disclosed |
| US-8703747-B2 | Aminophosphinic derivatives that can be used in the treatment of pain | PHARMALEADS (FR) | 2014-04-22 | — | — | US | disclosed |
| US-8338469-B2 | Compounds and compositions as channel activating protease inhibitors | IRM LLC (BM) | 2012-12-25 | — | — | US | disclosed |
| US-20110257077-A1 | COMPOUNDS AND COMPOSITIONS AS CHANNEL ACTIVATING PROTEASE INHIBITORS | IRM LLC (BM) | 2011-10-20 | — | — | US | disclosed |
| EP-2326655-A1 | AMINOPHOSPHINIC DERIVATIVES THAT CAN BE USED IN THE TREATMENT OF PAIN | Pharmaleads (FR) | 2011-06-01 | — | — | EP | disclosed |
| US-7951823-B2 | Compounds and compositions as channel activating protease inhibitors | IRM LLC (BM) | 2011-05-31 | — | — | US | disclosed |
| WO-2007137080-A2 | COMPOUNDS AND COMPOSITIONS AS CHANNEL ACTIVATING PROTEASE INHIBITORS | IRM LLC (BM) | 2007-11-29 | — | — | WO | disclosed |
| US-20070275906-A1 | Compounds and Compositions as Channel Activating Protease Inhibitors | IRM LLC (BM) | 2007-11-29 | — | — | US | disclosed |
| WO-2006130426-A2 | MODULATORS OF CCR-5 ACTIVITY | KEMIA, INC. (US) | 2006-12-07 | — | — | WO | disclosed |
| EP-0226217-B1 | Peptides with sulfate ester group | FISONS CORP (US) | 1994-01-26 | — | — | EP | disclosed |
| US-5086042-A | Capable of stimulating contraction of gall bladder; having six to nine amino acids with sulfonated tyrosine and C-terminal amides; treating obesity | FISONS CORPORATION (US) | 1992-02-04 | — | — | US | disclosed |
| EP-0417217-A1 | PEPTIDES WITH SULPHATE ESTER GROUPS | FISONS CORPORATION (US) | 1991-03-20 | — | — | EP | disclosed |
| WO-1990008773-A1 | PEPTIDES WITH SULPHATE ESTER GROUPS | FISONS CORPORATION (US) | 1990-08-09 | — | — | WO | disclosed |
| EP-0381340-A2 | Peptides with sulphate ester groups | FISONS CORPORATION (US) | 1990-08-08 | — | — | EP | disclosed |
| EP-0268297-A2 | Peptides with sulfate ester groups | FISONS CORPORATION (US) | 1988-05-25 | — | — | EP | disclosed |
| EP-0226217-A2 | Peptides with sulfate ester group | FISONS CORPORATION (a Massachusetts corporation) (US) | 1987-06-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257077-A1 | COMPOUNDS AND COMPOSITIONS AS CHANNEL ACTIVATING PROTEASE INHIBITORS | PRSS1, PRSS8, PRSS2 | KMT2A 4013/4885MEN1 2897/4885LMNA 1370/4885 |
| US-10131681-B2 | Aminophosphinic derivatives that can be used in the treatment of pain | OPRM1, HRH3, HRH4 | KMT2A 3249/4885MEN1 4339/4885LMNA 4614/4885 |
| US-20140161839-A1 | AMINOPHOSPHINIC DERIVATIVES THAT CAN BE USED IN THE TREATMENT OF PAIN | OPRM1, HRH3, HRH4 | KMT2A 3249/4885MEN1 4339/4885LMNA 4614/4885 |
| US-20070275906-A1 | Compounds and Compositions as Channel Activating Protease Inhibitors | PRSS1, PRSS8, PRSS2 | KMT2A 4013/4885MEN1 2897/4885LMNA 1370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.