Sugi Predict

Sugi Predict / Compounds / SCHEMBL17646302

SCHEMBL17646302

SCHEMBL17646302

O=[C]COc1c(F)c(F)cc(F)c1F

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 2/20 0.39
▸ ALDH1A1 P00352 2/20 0.36
▸ KDM4E B2RXH2 2/20 0.36
▸ HTT P42858 1/20 0.36
▸ MAPK1 P28482 1/20 0.36
▸ POLB P06746 1/20 0.31
▸ TSHR P16473 1/20 0.31
▸ MEN1 O00255 1/20 0.31
▸ NPC1 O15118 1/20 0.31
▸ RAB9A P51151 1/20 0.31
▸ KMT2A Q03164 1/20 0.31
▸ CA1 P00915 3/20 0.31
▸ CA2 P00918 3/20 0.31
▸ CA4 P22748 2/20 0.31
▸ CA12 O43570 1/20 0.31
▸ CA7 P43166 1/20 0.31
▸ CA13 Q8N1Q1 1/20 0.31
▸ CTSV O60911 1/20 0.30
▸ CTSL P07711 1/20 0.30
▸ CTSB P07858 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3715002 0.81 TSHR (0.32) MAPTPOLBTSHRCA1CA2
SCHEMBL28341050 0.74 CES2 (0.33) MEN1NPC1RAB9AKMT2ACA12
SCHEMBL7276616 0.71 AGBL2 (0.33) —
SCHEMBL12205723 0.70 MAPT (0.39) MAPTALDH1A1KDM4EHTTMAPK1
SCHEMBL4753814 0.70 ALDH1A1 (0.39) MAPTALDH1A1KDM4EHTTMAPK1
SCHEMBL1343627 0.70 MAPT (0.39) MAPTALDH1A1KDM4EHTTMAPK1
SCHEMBL18166924 0.70 CA1 (0.34) MAPTCA1CA2CA4CA12
SCHEMBL3216951 0.70 MAPT (0.50) MAPTALDH1A1KDM4EHTTMAPK1
SCHEMBL3216942 0.70 ALDH1A1 (0.43) MAPTALDH1A1KDM4EHTTMAPK1
SCHEMBL13382341 0.68 TSHR (0.56) MAPTALDH1A1KDM4EHTTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10906881-B2 Inhibitors of arginine gingipain Cortexyme, Inc. (US) 2021-02-02 — — US claimed
US-20180334440-A1 INHIBITORS OF ARGININE GINGIPAIN Cortexyme, Inc. (US) 2018-11-22 — — US claimed
EP-3374352-A1 INHIBITORS OF ARGININE GINGIPAIN Cortexyme, Inc. (US) 2018-09-19 — — EP claimed
WO-2017083433-A1 INHIBITORS OF ARGININE GINGIPAIN Cortexyme, Inc. (US) 2017-05-18 — — WO claimed
US-11332464-B2 Inhibitors of lysine gingipain Cortexyme, Inc. (US) 2022-05-17 — — US disclosed
US-10906881-B2 Inhibitors of arginine gingipain Cortexyme, Inc. (US) 2021-02-02 — — US disclosed
US-20210017167-A1 INHIBITORS OF LYSINE GINGIPAIN Cortexyme, Inc. (US) 2021-01-21 — — US disclosed
EP-3204352-B1 INHIBITORS OF LYSINE GINGIPAIN CORTEXYME INC (US) 2020-07-01 — — EP disclosed
CN-111349053-A Inhibitors of lysine porphyromonas gingivalis protease 库特克希米公司 2020-06-30 — — CN disclosed
US-10676470-B2 Inhibitors of lysine gingipain Cortexyme, Inc. (US) 2020-06-09 — — US disclosed
CN-107108468-B Inhibitors of lysine porphyromonas gingivalis protease 库特克希米公司 2020-01-03 — — CN disclosed
US-20190322659-A1 INHIBITORS OF LYSINE GINGIPAIN Cortexyme, Inc. (US) 2019-10-24 — — US disclosed
US-9988375-B2 Inhibitors of lysine gingipain Cortexyme, Inc. (US) 2018-06-05 — — US disclosed
US-20170349537-A1 INHIBITORS OF LYSINE GINGIPAIN Cortexyme, Inc. (US) 2017-12-07 — — US disclosed
WO-2017201322-A1 TREATMENT OF OSTEOARTHRITIS WITH GINGIPAIN BLOCKING AGENTS Cortexyme, Inc. (US) 2017-11-23 — — WO disclosed
US-9758473-B2 Inhibitors of lysine gingipain Cortexyme, Inc. (US) 2017-09-12 — — US disclosed
EP-3204352-A2 INHIBITORS OF LYSINE GINGIPAIN Cortexyme, Inc. (US) 2017-08-16 — — EP disclosed
WO-2017083433-A1 INHIBITORS OF ARGININE GINGIPAIN Cortexyme, Inc. (US) 2017-05-18 — — WO disclosed
WO-2016057413-A2 INHIBITORS OF LYSINE GINGIPAIN Cortexyme, Inc. (US) 2016-04-14 — — WO disclosed
US-20160096830-A1 INHIBITORS OF LYSINE GINGIPAIN Cortexyme, Inc. (US) 2016-04-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190322659-A1 INHIBITORS OF LYSINE GINGIPAIN ENPEP, PHYKPL, PREP MAPT 332/4885ALDH1A1 2355/4885KDM4E 71/4885
US-20210017167-A1 INHIBITORS OF LYSINE GINGIPAIN ENPEP, PHYKPL, PREP MAPT 332/4885ALDH1A1 2355/4885KDM4E 71/4885
US-10906881-B2 Inhibitors of arginine gingipain ARGLU1, ENPEP, PRAP1 MAPT 969/4885ALDH1A1 2785/4885KDM4E 2176/4885
US-10676470-B2 Inhibitors of lysine gingipain ENPEP, PHYKPL, PREP MAPT 332/4885ALDH1A1 2355/4885KDM4E 71/4885
US-20170349537-A1 INHIBITORS OF LYSINE GINGIPAIN ENPEP, PHYKPL, PREP MAPT 332/4885ALDH1A1 2355/4885KDM4E 71/4885
US-20160096830-A1 INHIBITORS OF LYSINE GINGIPAIN ENPEP, PHYKPL, PREP MAPT 332/4885ALDH1A1 2355/4885KDM4E 71/4885
US-11332464-B2 Inhibitors of lysine gingipain ENPEP, PHYKPL, PREP MAPT 332/4885ALDH1A1 2355/4885KDM4E 71/4885
US-20180334440-A1 INHIBITORS OF ARGININE GINGIPAIN ARGLU1, ENPEP, PRAP1 MAPT 969/4885ALDH1A1 2785/4885KDM4E 2176/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.