Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.49 |
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | MMP3 | P08254 | 2/20 | 0.41 |
| ▸ | MMP8 | P22894 | 2/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26812 | 0.88 | HTT (0.47) | SOS1LMNAHTTSMN1; SMN2CA1 | |
| SCHEMBL2724222 | 0.87 | CA12 (0.48) | CA1CA2CA9MMP1PTGS2 | |
| SCHEMBL22033289 | 0.83 | HTT (0.42) | SOS1LMNAHTTSMN1; SMN2KDM4E | |
| SCHEMBL5676376 | 0.83 | CA2 (0.41) | BCL2L1LMNAHTTSMN1; SMN2CA1 | |
| SCHEMBL81874 | 0.79 | HTR6 (0.44) | BCL2L1LMNAHTTSMN1; SMN2KDM4E | |
| Diphenylether SCHEMBL16004650 | 0.78 | LTA4H (0.48) | SOS1LMNAHTTSMN1; SMN2CA1 | |
| Phosphine SCHEMBL28308716 | 0.77 | HTR6 (0.42) | BCL2L1LMNAHTTSMN1; SMN2KDM4E | |
| Hydrogen Sulfide SCHEMBL28252271 | 0.77 | HTR6 (0.42) | BCL2L1LMNAHTTSMN1; SMN2KDM4E | |
| Methane SCHEMBL29217844 | 0.77 | HTR6 (0.42) | BCL2L1LMNAHTTSMN1; SMN2KDM4E | |
| SCHEMBL10823807 | 0.77 | CA1 (0.43) | BCL2L1LMNAHTTCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11479532-B2 | 5-aminolevulinate synthase inhibitors and methods of use thereof | UNIVERSITY OF SOUTH FLORIDA (US) | 2022-10-25 | — | — | US | disclosed |
| WO-2018237163-A1 | 5-AMINOLEVULINATE SYNTHASE INHIBITORS AND METHODS OF USE THEREOF | MANETSCH ROMAN (US) | 2018-12-27 | — | — | WO | disclosed |
| US-20160116482-A1 | Target Binding Molecules Identified by Kinetic Target-Guided Synthesis | THE PENN STATE RESEARCH FOUNDATION (US) | 2016-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160116482-A1 | Target Binding Molecules Identified by Kinetic Target-Guided Synthesis | MCL1, BCL2L1, BCL2L2 | SOS1 200/4885BCL2L1 2/4885MCL1 1/4885 |
| US-11479532-B2 | 5-aminolevulinate synthase inhibitors and methods of use thereof | ALAD, HMBS, PPOX | SOS1 3055/4885BCL2L1 3974/4885MCL1 2295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.