Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 14/20 | 0.70 |
| ▸ | YAP1 | P46937 | 1/20 | 0.67 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.67 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.67 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12606017 | 0.93 | RXFP1 (0.67) | RXFP1YAP1TEAD4TEAD2TRPV1 | |
| SCHEMBL13929951 | 0.91 | RXFP1 (0.64) | RXFP1YAP1TEAD4TEAD2TRPV1 | |
| SCHEMBL9268782 | 0.86 | RXFP1 (0.78) | RXFP1YAP1TEAD4TEAD2LMNA | |
| SCHEMBL13754010 | 0.85 | RXFP1 (0.73) | RXFP1YAP1TEAD4TEAD2TRPV1 | |
| SCHEMBL18752851 | 0.85 | RXFP1 (0.54) | RXFP1YAP1TEAD4TEAD2TRPV1 | |
| SCHEMBL18286751 | 0.84 | RXFP1 (0.53) | RXFP1YAP1TEAD4TEAD2TRPV1 | |
| SCHEMBL10310897 | 0.83 | LMNA (0.72) | RXFP1YAP1TEAD4TEAD2TRPV1 | |
| SCHEMBL1775112 | 0.83 | RXFP1 (0.65) | RXFP1YAP1TEAD4TEAD2TRPV1 | |
| SCHEMBL14192649 | 0.82 | RXFP1 (0.66) | RXFP1YAP1TEAD4TEAD2TRPV1 | |
| SCHEMBL15528884 | 0.82 | RXFP1 (1.00) | RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943775-B2 | to detect amyloid deposits prior to aggregation into plaques; labeled bifunctional compound binds to target protein and to chaperone protein; Alzheimer's; 1-[4-(carboxymethoxy)phenyl]-3-(3,4-dimethoxy-phenyl)-1-propanyl-1-(3,3-dimethyl-1,2-dioxopentyl)-2-piperidinecarboxylate isomers bind differently | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-05-17 | — | — | US | disclosed |
| US-20080085238-A1 | Small Molecules for Imaging Protein-Protein Interactions | The Government of the United States of America as represented (US) | 2008-04-10 | — | — | US | disclosed |
| US-20080085238-A1 | Small Molecules for Imaging Protein-Protein Interactions | The Government of the United States of America as represented (US) | 2008-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080085238-A1 | Small Molecules for Imaging Protein-Protein Interactions | HSPBP1, HSPA2, HSPA8 | RXFP1 2785/4885YAP1 2030/4885TEAD4 4460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.