Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1774421 | 0.84 | FEN1 (0.45) | TNKS2GPR84HTR2AFEN1DAO | |
| SCHEMBL4118331 | 0.81 | TNKS2 (0.46) | TNKS2GPR84HTR2AFEN1DAO | |
| SCHEMBL8368811 | 0.79 | ALDH1A1 (0.56) | TNKS2HPGDKDM4EALDH1A1MITF | |
| SCHEMBL1776571 | 0.77 | TSHR (0.52) | TNKS2GPR84FEN1LMNAHPGD | |
| SCHEMBL2798042 | 0.75 | TNKS2 (0.50) | TNKS2FEN1DAOLMNAHPGD | |
| SCHEMBL1378769 | 0.73 | TNKS2 (0.75) | TNKS2FEN1DAOLMNAHPGD | |
| SCHEMBL8871948 | 0.73 | LMNA (0.54) | TNKS2FEN1DAOLMNAHPGD | |
| SCHEMBL9766070 | 0.73 | PARP1 (0.45) | TNKS2FEN1HPGDNOS3NOS1 | |
| SCHEMBL9766056 | 0.72 | ALDH1A1 (0.46) | TNKS2HTR2ALMNAHPGDKDM4E | |
| SCHEMBL8369447 | 0.72 | AR (0.51) | TNKS2LMNAHPGDMITFPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943769-B2 | Fluorinated derivative of quinolin-2(1H)-one, method for preparing the same and use thereof as a synthesis intermediate | SANOFI-AVENTIS (FR) | 2011-05-17 | — | — | US | disclosed |
| EP-2102216-B1 | FLUORINATED DERIVATIVE OF QUINOLEINE-2(1H)-ONE, METHOD FOR PREPARING THE SAME AND USE THEREOF AS A SYNTHESIS INTERMEDIATE | SANOFI AVENTIS (FR) | 2010-07-21 | — | — | EP | disclosed |
| US-20100094005-A1 | FLUORINATED DERIVATIVE OF QUINOLIN-2(1H)-ONE, METHOD FOR PREPARING THE SAME AND USE THEREOF AS A SYNTHESIS INTERMEDIATE | SANOFI-AVENTIS (FR) | 2010-04-15 | — | — | US | disclosed |
| EP-2102216-A1 | FLUORINATED DERIVATIVE OF QUINOLEINE-2(1H)-ONE, METHOD FOR PREPARING THE SAME AND USE THEREOF AS A SYNTHESIS INTERMEDIATE | Sanofi-Aventis (FR) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008087277-A1 | FLUORINATED DERIVATIVE OF QUINOLEINE-2(1H)-ONE, METHOD FOR PREPARING THE SAME AND USE THEREOF AS A SYNTHESIS INTERMEDIATE | SANOFI-AVENTIS (FR) | 2008-07-24 | — | — | WO | disclosed |
| EP-0971928-A1 | QUINOLINE-2(1H)-ONE AND DIHYDROQUINOLINE-2(1H)-ONE DERIVATIVES AS LIGANDS OF 5-HT, 5-HT2 AND 5-HT1-LIKE RECEPTORS | SANOFI-SYNTHELABO (FR) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998042712-A1 | QUINOLINE-2(1H)-ONE AND DIHYDROQUINOLINE-2(1H)-ONE DERIVATIVES AS LIGANDS OF 5-HT, 5-HT2 AND 5-HT1-LIKE RECEPTORS | SANOFI-SYNTHELABO (FR) | 1998-10-01 | — | — | WO | disclosed |
| US-4983607-A | ANTISEROTONINERGIC ACTIVITY | SYNTHELABO (FR) | 1991-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100094005-A1 | FLUORINATED DERIVATIVE OF QUINOLIN-2(1H)-ONE, METHOD FOR PREPARING THE SAME AND USE THEREOF AS A SYNTHESIS INTERMEDIATE | NQO2, SULT2A1, CYP3A7 | TNKS2 692/4885GPR84 4226/4885HTR2A 906/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.