Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.43 |
| ▸ | MPL | P40238 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9766070 | 0.83 | PARP1 (0.45) | FEN1SMYD3TNKS2HPGDMEN1 | |
| SCHEMBL9155261 | 0.82 | GPR17 (0.48) | TSHRMPLHPGDMEN1KMT2A | |
| SCHEMBL1774421 | 0.80 | FEN1 (0.45) | FEN1SMYD3TNKS2HPGDLMNA | |
| SCHEMBL31376496 | 0.80 | ALDH1A1 (0.59) | TSHRTNKS2HPGDMEN1KMT2A | |
| SCHEMBL8366302 | 0.80 | ALDH1A1 (0.59) | TSHRTNKS2HPGDMEN1KMT2A | |
| SCHEMBL4118331 | 0.80 | TNKS2 (0.46) | FEN1SMYD3TNKS2HPGDLMNA | |
| SCHEMBL29651210 | 0.78 | TSHR (0.77) | TSHRHPGDLMNAMEN1KMT2A | |
| SCHEMBL4098433 | 0.78 | TSHR (0.77) | TSHRHPGDLMNAMEN1KMT2A | |
| SCHEMBL16510780 | 0.77 | LMNA (0.43) | TSHRSMYD3TNKS2HPGDLMNA | |
| SCHEMBL1775740 | 0.77 | TNKS2 (0.44) | FEN1SMYD3TNKS2HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943769-B2 | Fluorinated derivative of quinolin-2(1H)-one, method for preparing the same and use thereof as a synthesis intermediate | SANOFI-AVENTIS (FR) | 2011-05-17 | — | — | US | claimed |
| US-20100094005-A1 | FLUORINATED DERIVATIVE OF QUINOLIN-2(1H)-ONE, METHOD FOR PREPARING THE SAME AND USE THEREOF AS A SYNTHESIS INTERMEDIATE | SANOFI-AVENTIS (FR) | 2010-04-15 | — | — | US | claimed |
| US-7943769-B2 | Fluorinated derivative of quinolin-2(1H)-one, method for preparing the same and use thereof as a synthesis intermediate | SANOFI-AVENTIS (FR) | 2011-05-17 | — | — | US | disclosed |
| US-7943769-B2 | Fluorinated derivative of quinolin-2(1H)-one, method for preparing the same and use thereof as a synthesis intermediate | SANOFI-AVENTIS (FR) | 2011-05-17 | — | — | US | disclosed |
| US-7943769-B2 | Fluorinated derivative of quinolin-2(1H)-one, method for preparing the same and use thereof as a synthesis intermediate | SANOFI-AVENTIS (FR) | 2011-05-17 | — | — | US | disclosed |
| US-20100094005-A1 | FLUORINATED DERIVATIVE OF QUINOLIN-2(1H)-ONE, METHOD FOR PREPARING THE SAME AND USE THEREOF AS A SYNTHESIS INTERMEDIATE | SANOFI-AVENTIS (FR) | 2010-04-15 | — | — | US | disclosed |
| US-20100094005-A1 | FLUORINATED DERIVATIVE OF QUINOLIN-2(1H)-ONE, METHOD FOR PREPARING THE SAME AND USE THEREOF AS A SYNTHESIS INTERMEDIATE | SANOFI-AVENTIS (FR) | 2010-04-15 | — | — | US | disclosed |
| US-20100094005-A1 | FLUORINATED DERIVATIVE OF QUINOLIN-2(1H)-ONE, METHOD FOR PREPARING THE SAME AND USE THEREOF AS A SYNTHESIS INTERMEDIATE | SANOFI-AVENTIS (FR) | 2010-04-15 | — | — | US | disclosed |
| WO-2008087277-A1 | FLUORINATED DERIVATIVE OF QUINOLEINE-2(1H)-ONE, METHOD FOR PREPARING THE SAME AND USE THEREOF AS A SYNTHESIS INTERMEDIATE | SANOFI-AVENTIS (FR) | 2008-07-24 | — | — | WO | disclosed |
| US-4983607-A | ANTISEROTONINERGIC ACTIVITY | SYNTHELABO (FR) | 1991-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100094005-A1 | FLUORINATED DERIVATIVE OF QUINOLIN-2(1H)-ONE, METHOD FOR PREPARING THE SAME AND USE THEREOF AS A SYNTHESIS INTERMEDIATE | NQO2, SULT2A1, CYP3A7 | TSHR 3536/4885FEN1 2772/4885PTGS1 770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.