Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 3/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | PELP1 | Q8IZL8 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17775442 | 0.85 | ALDH1A1 (0.47) | MAPTALDH1A1MAPK1SMN1; SMN2EP300 | |
| SCHEMBL16371049 | 0.84 | MAPT (0.48) | MAPTALDH1A1MAPK1EP300AR | |
| SCHEMBL21137817 | 0.84 | GAA (0.42) | MAPTALDH1A1MAPK1SMN1; SMN2EP300 | |
| SCHEMBL11959264 | 0.81 | KDM4E (0.42) | MAPTALDH1A1MAPK1EP300AR | |
| SCHEMBL16392500 | 0.79 | EP300 (0.52) | MAPTALDH1A1MAPK1EP300AR | |
| SCHEMBL21138155 | 0.77 | EP300 (0.48) | MAPTALDH1A1MAPK1SMN1; SMN2EP300 | |
| SCHEMBL24379797 | 0.77 | EP300 (0.53) | MAPTALDH1A1SMN1; SMN2EP300HDAC1 | |
| SCHEMBL28525705 | 0.76 | NAMPT (0.38) | NAMPTSMN1; SMN2TP53HDAC1NPC1 | |
| SCHEMBL16392496 | 0.76 | AR (0.58) | MAPTEP300ARPELP1HIF1A | |
| SCHEMBL16392463 | 0.76 | EP300 (0.57) | EP300HDAC1HIF1ARAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11225503-B2 | Crystobactamides | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2022-01-18 | — | — | US | disclosed |
| US-20200331964-A1 | CYSTOBACTAMIDES | HELMHOLTZ ZENTRUM INFEKTIONSFORSCHUNG GMBH (DE) | 2020-10-22 | — | — | US | disclosed |
| US-10793600-B2 | Cystobactamides | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2020-10-06 | — | — | US | disclosed |
| US-20190185514-A1 | CYSTOBACTAMIDES | HELMHOLTZ ZENTRUM INFEKTIONSFORSCHUNG GMBH (DE) | 2019-06-20 | — | — | US | disclosed |
| US-20160145304-A1 | CYSTOBACTAMIDES | HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH (DE) | 2016-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160145304-A1 | CYSTOBACTAMIDES | CTH, SLC7A11, CBS | MAPT 3395/4885ALDH1A1 2000/4885MAPK1 4212/4885 |
| US-11225503-B2 | Crystobactamides | PKD2, SLC7A11, CTH | MAPT 1600/4885ALDH1A1 2778/4885MAPK1 4415/4885 |
| US-20190185514-A1 | CYSTOBACTAMIDES | CTH, SLC7A11, SULT2A1 | MAPT 3912/4885ALDH1A1 861/4885MAPK1 4415/4885 |
| US-20200331964-A1 | CYSTOBACTAMIDES | CTH, SLC7A11, SULT2A1 | MAPT 3765/4885ALDH1A1 1028/4885MAPK1 4386/4885 |
| US-10793600-B2 | Cystobactamides | CTH, SLC7A11, SULT2A1 | MAPT 3953/4885ALDH1A1 737/4885MAPK1 4357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.