Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MMP3 | P08254 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HRH2 | P25021 | 4/20 | 0.49 |
| ▸ | HRH1 | P35367 | 4/20 | 0.49 |
| ▸ | MMP2 | P08253 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6731770 | 1.00 | HRH3 (0.58) | HRH3HDAC1HDAC2ALDH1A1MAPT | |
| SCHEMBL8748087 | 0.98 | HRH3 (0.56) | HRH3HDAC1HDAC2ALDH1A1MAPT | |
| SCHEMBL6709103 | 0.92 | MMP3 (0.59) | HRH3HDAC1HDAC2ALDH1A1MMP3 | |
| SCHEMBL1714609 | 0.92 | HRH3 (0.54) | HRH3HDAC1HDAC2ALDH1A1MAPT | |
| SCHEMBL12408526 | 0.92 | HRH3 (0.66) | HRH3HDAC1HDAC2ALDH1A1MAPT | |
| SCHEMBL5526919 | 0.92 | HRH3 (0.66) | HRH3HDAC1HDAC2ALDH1A1MAPT | |
| SCHEMBL7387284 | 0.92 | HRH3 (0.66) | HRH3HDAC1HDAC2ALDH1A1MAPT | |
| SCHEMBL7983991 | 0.92 | HRH3 (0.66) | HRH3HDAC1HDAC2ALDH1A1MAPT | |
| SCHEMBL5519875 | 0.89 | HRH3 (0.62) | HRH3HDAC1HDAC2ALDH1A1MAPT | |
| SCHEMBL7447851 | 0.88 | ALDH1A1 (0.53) | HRH3ALDH1A1MAPTMMP3HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1980905-B | An improved process for preparing n-hydroxy-4-{5- [4- (5-isopropyl-2-methyl-l, 3-thiazol-4-yl) -phenoxy] -pentoxy }-benzamidine | DONG WHA PHARM IND CO LTD | 2010-04-21 | — | — | CN | claimed |
| EP-1773794-A4 | AN IMPROVED PROCESS FOR PREPARING N-HYDROXY-4-[5- [4- (5-ISOPROPYL-2-METHYL-l, 3-THIAZOL-4-YL) -PHENOXY] -PENTOXY]-BENZAMIDINE | DONG WHA PHARM IND CO LTD (KR) | 2009-09-09 | — | — | EP | claimed |
| US-7585979-B2 | Process for preparing N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)-phenoxy]-pentoxy}-benzamidine | DONG WHA PHARMACEUTICAL IND. CO., LTD. (KR) | 2009-09-08 | — | — | US | claimed |
| US-20080125596-A1 | Process For Preparing N-Hydroxy-4--Benzamidine | DONG WHA PHARMACEUTICAL CO., LTD. (KR) | 2008-05-29 | — | — | US | claimed |
| CN-1980905-A | An improved process for preparing n-hydroxy-4-{5- [4- (5-isopropyl-2-methyl-l, 3-thiazol-4-yl) -phenoxy] -pentoxy }-benzamidine | DONG WHA PHARM IND CO LTD (KR) | 2007-06-13 | — | — | CN | claimed |
| EP-1773794-A1 | AN IMPROVED PROCESS FOR PREPARING N-HYDROXY-4-[5- [4- (5-ISOPROPYL-2-METHYL-l, 3-THIAZOL-4-YL) -PHENOXY] -PENTOXY]-BENZAMIDINE | DONG WHA PHARMACEUTICAL INDUSTRIAL CO. LTD. (KR) | 2007-04-18 | — | — | EP | claimed |
| WO-2006004368-A1 | AN IMPROVED PROCESS FOR PREPARING N-HYDROXY-4-{5- [4- (5-ISOPROPYL-2-METHYL-l, 3-THIAZOL-4-YL) -PHENOXY] -PENTOXY }-BENZAMIDINE | DONG WHA PHARMACEUTICAL. IND. CO., LTD. (KR) | 2006-01-12 | — | — | WO | claimed |
| EP-1781629-B1 | NOVEL BENZAMIDINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONG WHA PHARM CO LTD (KR) | 2015-07-29 | — | — | EP | disclosed |
| US-8178688-B2 | Benzamidine derivatives, process for the preparation thereof and pharmaceutical composition comprising the same | DONG WHA PHARMACEUTICAL CO., LTD. (KR) | 2012-05-15 | — | — | US | disclosed |
| CN-101379049-B | Novel benzamidine derivatives, process for preparing the same, and pharmaceutical composition comprising the same | DONG WHA PHARM IND CO LTD | 2012-01-04 | — | — | CN | disclosed |
| EP-1979334-B1 | NOVEL BENZAMIDINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONG WHA PHARM CO LTD (KR) | 2011-06-22 | — | — | EP | disclosed |
| US-7943646-B2 | Benzamidine derivative, process for the preparation thereof and pharmaceutical composition comprising same | DONG WHA PHARMACEUTICAL CO., LTD. (KR) | 2011-05-17 | — | — | US | disclosed |
| US-20100249402-A1 | NOVEL BENZAMIDINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OSTEPOROSIS COMPRISING THE SAME | DONG WHA PHARMACEUTICAL CO. LTD. (KR) | 2010-09-30 | — | — | US | disclosed |
| WO-2006014087-A1 | NOVEL BENZAMIDINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONG WHA PHARMACEUTICAL. IND. CO., LTD. (KR) | 2006-02-09 | — | — | WO | disclosed |
| WO-2006004368-A1 | AN IMPROVED PROCESS FOR PREPARING N-HYDROXY-4-{5- [4- (5-ISOPROPYL-2-METHYL-l, 3-THIAZOL-4-YL) -PHENOXY] -PENTOXY }-BENZAMIDINE | DONG WHA PHARMACEUTICAL. IND. CO., LTD. (KR) | 2006-01-12 | — | — | WO | disclosed |
| EP-0601977-B1 | Aromatic hydroxyamidine derivatives and their use as leukotriene B4 receptor antagonists | CIBA GEIGY AG (CH) | 1997-01-22 | — | — | EP | disclosed |
| US-5455274-A | Leukotriene antagonists; treating rheumatoid arthritis | CIBA-GEIGY CORPORATION (US) | 1995-10-03 | — | — | US | disclosed |
| EP-0601977-A1 | Aromatic hydroxyamidine derivatives and their use as leukotriene B4 receptor anagonists | CIBA-GEIGY AG (CH) | 1994-06-15 | — | — | EP | disclosed |
| US-5246965-A | Leukotriene antagonist | CIBA-GEIGY (US) | 1993-09-21 | — | — | US | disclosed |
| EP-0518818-A2 | Arylethers, their manufacture and use as medicament | CIBA-GEIGY AG (CH) | 1992-12-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249402-A1 | NOVEL BENZAMIDINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OSTEPOROSIS COMPRISING THE SAME | SOST, CTSA, BECN1 | HRH3 167/4885HDAC1 1363/4885HDAC2 353/4885 |
| US-20080125596-A1 | Process For Preparing N-Hydroxy-4--Benzamidine | HNMT, HTR4, PNMT | HRH3 15/4885HDAC1 2806/4885HDAC2 2208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.