Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 7/20 | 0.56 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.54 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.54 |
| ▸ | SLC25A1 | P53007 | 1/20 | 0.54 |
| ▸ | CCR2 | P41597 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.49 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.49 |
| ▸ | SLC10A6 | Q3KNW5 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17843852 | 0.81 | VCAM1 (0.60) | VCAM1DNMT1DNMT3ASLC25A1CCR2 | |
| SCHEMBL11749307 | 0.80 | SLC25A1 (0.68) | VCAM1DNMT1DNMT3ASLC25A1CCR2 | |
| SCHEMBL17843843 | 0.78 | DNMT1 (0.56) | VCAM1DNMT1DNMT3ASLC25A1CCR2 | |
| SCHEMBL1250772 | 0.75 | VCAM1 (0.62) | VCAM1DNMT1DNMT3ASLC25A1LMNA | |
| SCHEMBL8113261 | 0.75 | MAPT (0.62) | VCAM1DNMT1DNMT3ASLC25A1CCR2 | |
| SCHEMBL7595588 | 0.74 | CCR2 (0.65) | VCAM1DNMT1DNMT3ASLC25A1CCR2 | |
| SCHEMBL686821 | 0.73 | VCAM1 (1.00) | VCAM1DNMT1DNMT3ASLC25A1LMNA | |
| SCHEMBL11137623 | 0.73 | CCR2 (0.61) | VCAM1DNMT1DNMT3ASLC25A1CCR2 | |
| SCHEMBL10657289 | 0.73 | ALDH1A1 (0.71) | VCAM1DNMT1DNMT3ASLC25A1CCR2 | |
| SCHEMBL3611184 | 0.72 | ALDH1A1 (0.80) | VCAM1DNMT1DNMT3ASLC25A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107257791-B | Benzimidazole sulfonamide derivatives as inverse agonists of the retinoid-related orphan receptor gamma ROR gamma (t) | 盖尔德马研究及发展公司 | 2021-06-11 | — | — | CN | disclosed |
| US-10618890-B2 | Benzimidazole sulfonamide derivatives as inverse agonists of retinoid-related orphan receptor gamma (ROR gamma (T)) | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2020-04-14 | — | — | US | disclosed |
| US-20190071433-A1 | BENZIMIDAZOLE SULFONAMIDE DERIVATIVES AS INVERSE AGONISTS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR GAMMA (T)) | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2019-03-07 | — | — | US | disclosed |
| EP-3233838-B1 | BENZIMIDAZOLE SULFONAMIDE DERIVATIVES AS INVERSE AGONISTS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR GAMMA (T)) | GALDERMA RES & DEV (FR) | 2019-01-30 | — | — | EP | disclosed |
| EP-3233838-A1 | BENZIMIDAZOLE SULFONAMIDE DERIVATIVES AS INVERSE AGONISTS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR GAMMA (T)) | Galderma Research & Development (FR) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016097393-A1 | BENZIMIDAZOLE SULFONAMIDE DERIVATIVES AS INVERSE AGONISTS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR GAMMA (T)) | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2016-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190071433-A1 | BENZIMIDAZOLE SULFONAMIDE DERIVATIVES AS INVERSE AGONISTS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR GAMMA (T)) | RORA, RORB, RORC | VCAM1 3310/4885DNMT1 4458/4885DNMT3A 4040/4885 |
| US-10618890-B2 | Benzimidazole sulfonamide derivatives as inverse agonists of retinoid-related orphan receptor gamma (ROR gamma (T)) | RORA, RORB, RORC | VCAM1 3310/4885DNMT1 4458/4885DNMT3A 4040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.