Sugi Predict

Sugi Predict / Compounds / SCHEMBL1785293

SCHEMBL1785293

SCHEMBL1785293

CCOC(=O)[C@H](O)Cc1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MMP8 P22894 2/20 0.59
▸ CYP1A2 P05177 2/20 0.54
▸ CYP2C9 P11712 1/20 0.54
▸ HIF1A Q16665 1/20 0.54
▸ ALDH1A1 P00352 2/20 0.52
▸ TP53 P04637 1/20 0.52
▸ NPY1R P25929 1/20 0.51
▸ NPY2R P49146 1/20 0.51
▸ PIN1 Q13526 1/20 0.50
▸ PKM P14618 1/20 0.49
▸ EPHX2 P34913 1/20 0.49
▸ PPARG P37231 1/20 0.49
▸ MEN1 O00255 1/20 0.49
▸ NPC1 O15118 1/20 0.49
▸ KMT2A Q03164 1/20 0.49
▸ L3MBTL1 Q9Y468 3/20 0.48
▸ SMN1; SMN2 Q16637 2/20 0.48
▸ LMNA P02545 2/20 0.48
▸ POLB P06746 1/20 0.47
▸ HSD17B10 Q99714 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6284464 1.00 MMP8 (0.59) MMP8CYP1A2CYP2C9HIF1AALDH1A1
SCHEMBL1245765 1.00 MMP8 (0.59) MMP8CYP1A2CYP2C9HIF1AALDH1A1
SCHEMBL5390701 0.93 MMP8 (0.54) MMP8CYP1A2CYP2C9HIF1AALDH1A1
SCHEMBL5375675 0.87 L3MBTL1 (0.65) ALDH1A1PPARGL3MBTL1LMNA
SCHEMBL1596779 0.87 L3MBTL1 (0.65) ALDH1A1PPARGL3MBTL1LMNA
SCHEMBL4756342 0.87 L3MBTL1 (0.65) ALDH1A1PPARGL3MBTL1LMNA
SCHEMBL5810826 0.86 LMNA (0.51) MMP8CYP1A2ALDH1A1PPARGNPC1
SCHEMBL14305548 0.85 NPY1R (0.56) MMP8CYP1A2CYP2C9HIF1AALDH1A1
SCHEMBL5385979 0.84 ESR1 (0.50) MMP8CYP1A2CYP2C9HIF1A
SCHEMBL5100527 0.84 ESR1 (0.50) MMP8CYP1A2CYP2C9HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1379748-A Process for preparing optically active alpha-hydroxy acids and derivatives thereof SCINOPHARM SINGAPORE PTE LTD (SG) 2002-11-13 — — CN claimed
CN-111741956-B Antiparasitic depsipeptides 硕腾服务有限责任公司 2023-07-07 — — CN disclosed
WO-2022235866-A1 COVALENT RAS INHIBITORS AND USES THEREOF Revolution Medicines, Inc. (US) 2022-11-10 — — WO disclosed
CN-111741956-A Antiparasitic depsipeptides 硕腾服务有限责任公司 2020-10-02 — — CN disclosed
EP-2735561-B1 Substituted carbamoylmethoxyacetic acid derivatives as novel NEP inhibitors NOVARTIS AG (CH) 2016-07-20 — — EP disclosed
US-8877786-B2 Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors NOVARTIS AG (CH) 2014-11-04 — — US disclosed
EP-2735561-A1 Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors Novartis AG (CH) 2014-05-28 — — EP disclosed
EP-2501683-B1 SUBSTITUTED CARBAMOYLMETHYLAMINO ACETIC ACID DERIVATIVES AS NOVEL NEP INHIBITORS NOVARTIS AG (CH) 2014-04-23 — — EP disclosed
US-20140088165-A1 Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors NOVARTIS AG (CH) 2014-03-27 — — US disclosed
US-8642635-B2 Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors NOVARTIS AG (CH) 2014-02-04 — — US disclosed
US-20130096168-A1 Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors NOVARTIS AG (CH) 2013-04-18 — — US disclosed
US-8377978-B2 Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors NOVARTIS AG (CH) 2013-02-19 — — US disclosed
US-20120202862-A1 Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors NOVARTIS AG (CH) 2012-08-09 — — US disclosed
US-8222286-B2 Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors NOVARTIS AG (CH) 2012-07-17 — — US disclosed
US-20110124695-A1 Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors NOVARTIS AG (CH) 2011-05-26 — — US disclosed
US-7767811-B2 Kinetic resolutions of chiral 2- and 3-substituted carboxylic acids BRANDEIS UNIVERSITY (US) 2010-08-03 — — US disclosed
WO-2010033466-A1 MACROCYCLIC INHIBITORS OF HEPATITIS C PROTEASE PHENOMIX CORPORATION (US) 2010-03-25 — — WO disclosed
WO-2010033466-A1 MACROCYCLIC INHIBITORS OF HEPATITIS C PROTEASE PHENOMIX CORPORATION (US) 2010-03-25 — — WO disclosed
WO-2007005935-A2 NOREPINEPHRINE TRANSPORTER RADIOTRACERS AND METHODS OF SYNTHESES THEREOF MOLECULAR NEUROIMAGING, LLC (US) 2007-01-11 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140088165-A1 Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors MME, REN, AGTR1 MMP8 814/4885CYP1A2 1512/4885CYP2C9 1964/4885
US-20130096168-A1 Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors MME, REN, AGTR1 MMP8 814/4885CYP1A2 1512/4885CYP2C9 1964/4885
US-20120202862-A1 Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors MME, REN, AGTR1 MMP8 814/4885CYP1A2 1512/4885CYP2C9 1964/4885
US-20110124695-A1 Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors MME, REN, AGTR1 MMP8 828/4885CYP1A2 1508/4885CYP2C9 1943/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.