Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 6/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | COMT | P21964 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | GPR3 | P46089 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28849047 | 0.87 | MAPT (0.38) | MAPTTP53SMN1; SMN2THRBTRPM8 | |
| SCHEMBL24726391 | 0.79 | MAOA (0.34) | MAPTTP53SMN1; SMN2THRBTRPM8 | |
| SCHEMBL15782859 | 0.77 | NPC1 (0.43) | MAPTTRPM8NPC1MAOATDP1 | |
| SCHEMBL17891984 | 0.73 | KMT2A (0.40) | NPC1MAOATDP1KDM4EGPR3 | |
| SCHEMBL24725971 | 0.73 | GAA (0.46) | NPC1RAB9A | |
| SCHEMBL17898588 | 0.72 | NPC1 (0.35) | MAPTTRPM8NPC1MAOATDP1 | |
| SCHEMBL28592395 | 0.66 | COMT (0.41) | MAPTCOMTTDP1KDM4EALDH1A1 | |
| SCHEMBL8882478 | 0.66 | FDPS (0.43) | MAPTTP53SMN1; SMN2NPC1TDP1 | |
| SCHEMBL9278016 | 0.65 | PRKCZ (0.41) | TP53SMN1; SMN2COMTMEN1KMT2A | |
| SCHEMBL13310735 | 0.65 | PIN1 (0.43) | NPC1MAOAKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10196398-B2 | Pesticidally active tetracyclic derivatives with sulfur containing substituents | SYNGENTA PARTICIPATIONS AG (CH) | 2019-02-05 | — | — | US | disclosed |
| US-10196398-B2 | Pesticidally active tetracyclic derivatives with sulfur containing substituents | SYNGENTA PARTICIPATIONS AG (CH) | 2019-02-05 | — | — | US | disclosed |
| EP-3240788-B1 | PESTICIDALLY ACTIVE TETRACYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS | SYNGENTA PARTICIPATIONS AG (CH) | 2018-09-26 | — | — | EP | disclosed |
| US-20180009813-A1 | PESTICIDALLY ACTIVE TETRACYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS | SYNGENTA PARTICIPATIONS AG (CH) | 2018-01-11 | — | — | US | disclosed |
| US-20180009813-A1 | PESTICIDALLY ACTIVE TETRACYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS | SYNGENTA PARTICIPATIONS AG (CH) | 2018-01-11 | — | — | US | disclosed |
| EP-3240788-A1 | PESTICIDALLY ACTIVE TETRACYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS | Syngenta Participations AG (CH) | 2017-11-08 | — | — | EP | disclosed |
| WO-2016107742-A1 | PESTICIDALLY ACTIVE TETRACYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS | SYNGENTA PARTICIPATIONS AG (CH) | 2016-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180009813-A1 | PESTICIDALLY ACTIVE TETRACYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS | DDT, TST, GSTO1 | MAPT 574/4885TP53 4487/4885SMN1; SMN2 400/4885 |
| US-10196398-B2 | Pesticidally active tetracyclic derivatives with sulfur containing substituents | DDT, TST, GSTO1 | MAPT 574/4885TP53 4487/4885SMN1; SMN2 400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.