Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21769573 | 0.93 | POLB (0.39) | SMN1; SMN2MEN1KMT2AMAPTTHRB | |
| SCHEMBL21769740 | 0.91 | L3MBTL1 (0.33) | SMN1; SMN2MEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL21769854 | 0.89 | KMT2A (0.39) | MEN1KMT2AMAPTTHRBL3MBTL1 | |
| SCHEMBL2237688 | 0.89 | HDAC1 (0.39) | SMN1; SMN2MEN1KMT2AMAPTTHRB | |
| SCHEMBL17923453 | 0.89 | MAPT (0.35) | MEN1KMT2AMAPTTHRBL3MBTL1 | |
| SCHEMBL17923455 | 0.89 | MAPT (0.37) | SMN1; SMN2MEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL21769874 | 0.88 | MAPT (0.38) | SMN1; SMN2MEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL21769731 | 0.88 | KMT2A (0.40) | SMN1; SMN2MEN1KMT2AMAPTPOLB | |
| SCHEMBL21769885 | 0.86 | POLB (0.37) | SMN1; SMN2MAPTPOLBKDM4EALDH1A1 | |
| SCHEMBL6011837 | 0.85 | ALDH1A1 (0.36) | SMN1; SMN2MEN1KMT2AMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2263671-B1 | AMIDE DERIVATIVE-CONTAINING PHARMACEUTICAL COMPOSITION | ASTELLAS PHARMA INC (JP) | 2016-07-20 | — | — | EP | claimed |
| WO-2020038812-A1 | NEW PROCESS FOR THE PREPARATION OF AMENAMEVIR | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2020-02-27 | — | — | WO | disclosed |