Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13351848 | 0.99 | MEN1 (0.39) | MEN1LMNAMAPTTHRBHTT | |
| SCHEMBL12617278 | 0.99 | MEN1 (0.39) | MEN1LMNAMAPTTHRBHTT | |
| SCHEMBL1797109 | 0.91 | LMNA (0.39) | MEN1LMNAMAPTTHRBHTT | |
| SCHEMBL2917375 | 0.91 | LMNA (0.39) | MEN1LMNAMAPTTHRBHTT | |
| SCHEMBL1797104 | 0.90 | LMNA (0.38) | MEN1LMNAMAPTTHRBHTT | |
| SCHEMBL137087 | 0.89 | PTPN1 (0.30) | — | |
| SCHEMBL2064627 | 0.87 | LMNA (0.38) | MEN1LMNAMAPTTHRBHTT | |
| SCHEMBL15927005 | 0.87 | S1PR3 (0.35) | — | |
| SCHEMBL10037957 | 0.86 | S1PR3 (0.32) | — | |
| SCHEMBL8116380 | 0.86 | PTPN1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951959-B2 | Hydrophilic labels for biomolecules | Thermo Fisher Scientific (Milwaukee) LLC (US) | 2011-05-31 | — | — | US | disclosed |
| US-7745640-B2 | Hydrophilic labels for biomolecules | DYOMICS GMBH (DE) | 2010-06-29 | — | — | US | disclosed |
| EP-2184326-A2 | Hydrophilic labels for biomolecules | Thermo Fischer (Milwaukee) LLC (US) | 2010-05-12 | — | — | EP | disclosed |
| US-20100069258-A1 | Hydrophilic Labels for Biomolecules | Thermo Fisher Scientific (Milwaukee) LLC (US) | 2010-03-18 | — | — | US | disclosed |
| US-20070128659-A1 | HYDROPHILIC LABELS FOR BIOMOLECULES | DYOMICS GMBH (DE) | 2007-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069258-A1 | Hydrophilic Labels for Biomolecules | HIRA, ALB, SSB | THRB 3207/4885MEN1 2655/4885LMNA 261/4885 |
| US-20070128659-A1 | HYDROPHILIC LABELS FOR BIOMOLECULES | DDB1, ALB, HIRA | THRB 4148/4885MEN1 2710/4885LMNA 150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.