Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | PGK1 | P00558 | 10/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4194117 | 0.82 | TLR8 (0.44) | LMNAL3MBTL1KMT2AHDAC1HDAC2 | |
| SCHEMBL24765256 | 0.81 | NUDT1 (0.46) | L3MBTL1PGK1MAPK8 | |
| SCHEMBL1935303 | 0.81 | STK17B (0.47) | LMNAALDH1A1L3MBTL1PGK1MEN1 | |
| SCHEMBL4137651 | 0.81 | NUDT1 (0.51) | ALDH1A1L3MBTL1CSNK1A1CLK4MEN1 | |
| SCHEMBL3564431 | 0.79 | NUDT1 (0.41) | LMNAALDH1A1L3MBTL1PGK1MEN1 | |
| SCHEMBL2265828 | 0.79 | XDH (0.41) | ALDH1A1L3MBTL1CSNK1A1CLK4MEN1 | |
| SCHEMBL14941832 | 0.78 | CYP1A2 (0.44) | LMNAALDH1A1L3MBTL1HDAC1HDAC2 | |
| SCHEMBL3646724 | 0.78 | LMNA (0.39) | LMNAALDH1A1L3MBTL1PGK1MEN1 | |
| SCHEMBL13897499 | 0.78 | MEN1 (0.52) | LMNAALDH1A1L3MBTL1PGK1MEN1 | |
| SCHEMBL1427747 | 0.78 | ALDH1A1 (0.63) | LMNAALDH1A1L3MBTL1PGK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120040951-A1 | HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | SUNESIS PHARMACEUTICALS, INC. | 2012-02-16 | — | — | US | disclosed |
| US-20120040951-A1 | HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | SUNESIS PHARMACEUTICALS, INC. | 2012-02-16 | — | — | US | disclosed |
| US-20110230480-A1 | 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS | COLE ANDREW G | 2011-09-22 | — | — | US | disclosed |
| US-20110230480-A1 | 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS | COLE ANDREW G | 2011-09-22 | — | — | US | disclosed |
| US-20110230480-A1 | 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS | COLE ANDREW G | 2011-09-22 | — | — | US | disclosed |
| US-7951803-B2 | 8-heteroarylpurine MNK2 inhibitors for treating metabolic disorders | PHARMACOPEIA, LLC (US) | 2011-05-31 | — | — | US | disclosed |
| US-7951803-B2 | 8-heteroarylpurine MNK2 inhibitors for treating metabolic disorders | PHARMACOPEIA, LLC (US) | 2011-05-31 | — | — | US | disclosed |
| US-7951803-B2 | 8-heteroarylpurine MNK2 inhibitors for treating metabolic disorders | PHARMACOPEIA, LLC (US) | 2011-05-31 | — | — | US | disclosed |
| EP-1991547-A2 | 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS | PHARMACOPEIA, INC. (US) | 2008-11-19 | — | — | EP | disclosed |
| US-20080032971-A1 | 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS | PHARMACOPEIA DRUG DISCOVERY, INC. (US) | 2008-02-07 | — | — | US | disclosed |
| US-20080032971-A1 | 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS | PHARMACOPEIA DRUG DISCOVERY, INC. (US) | 2008-02-07 | — | — | US | disclosed |
| US-20080032971-A1 | 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS | PHARMACOPEIA DRUG DISCOVERY, INC. (US) | 2008-02-07 | — | — | US | disclosed |
| WO-2007104053-A2 | 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS | PHARMACOPEIA, INC. (US) | 2007-09-13 | — | — | WO | disclosed |
| WO-2007104053-A2 | 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS | PHARMACOPEIA, INC. (US) | 2007-09-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230480-A1 | 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS | PCK2, UCK2, PANK2 | LMNA 3945/4885ALDH1A1 3341/4885L3MBTL1 1749/4885 |
| US-20080032971-A1 | 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS | PCK2, UCK2, PANK2 | LMNA 3945/4885ALDH1A1 3341/4885L3MBTL1 1749/4885 |
| US-20120040951-A1 | HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | BRAF, RAF1, ARAF | LMNA 3593/4885ALDH1A1 1934/4885L3MBTL1 2555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.