Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.46 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.36 |
| ▸ | GRIK1 known ✓ | P39086 | 1/20 | 0.36 |
| ▸ | GRIK2 known ✓ | Q13002 | 1/20 | 0.36 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | ADH1B | P00325 | 1/20 | 0.36 |
| ▸ | ADH1C | P00326 | 1/20 | 0.36 |
| ▸ | ADH1A | P07327 | 1/20 | 0.36 |
| ▸ | ADH4 | P08319 | 1/20 | 0.36 |
| ▸ | ADH7 | P40394 | 1/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL2376537 | 1.00 | OPRM1 (0.46) | OPRM1SPHK1LMNATP53DNM1 | |
| Water SCHEMBL28466171 | 1.00 | OPRM1 (0.46) | OPRM1SPHK1LMNATP53DNM1 | |
| Water SCHEMBL992804 | 1.00 | OPRM1 (0.46) | OPRM1SPHK1LMNATP53DNM1 | |
| Water SCHEMBL8529604 | 1.00 | OPRM1 (0.46) | OPRM1SPHK1LMNATP53DNM1 | |
| Water SCHEMBL8062330 | 1.00 | OPRM1 (0.46) | OPRM1SPHK1LMNATP53DNM1 | |
| Ammonia Solution, Strong SCHEMBL28023979 | 0.98 | OPRM1 (0.44) | OPRM1SPHK1LMNATP53DNM1 | |
| SCHEMBL8383457 | 0.98 | OPRM1 (0.48) | OPRM1SPHK1LMNATP53DNM1 | |
| SCHEMBL37786 | 0.98 | OPRM1 (0.48) | OPRM1SPHK1LMNATP53DNM1 | |
| SCHEMBL8386214 | 0.98 | OPRM1 (0.48) | OPRM1SPHK1LMNATP53DNM1 | |
| SCHEMBL125359 | 0.98 | OPRM1 (0.48) | OPRM1SPHK1LMNATP53DNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115124049-A | Method for synthesizing FER zeolite nanosheet with controllable thickness by using small-molecule template agent | 浙江大学 | 2022-09-30 | — | — | CN | claimed |
| EP-2321221-B1 | LOW COST ROUTES TO HIGH PURITY SILICON AND DERIVATIVES THEREOF | MAYATERIALS INC (US) | 2017-03-15 | — | — | EP | claimed |
| US-20130217872-A1 | METHOD FOR PRODUCING COMPOSITE GEL BY CROSS-LINKING HYALURONIC ACID AND HYDROXYPROPYL METHYLCELLULOSE | BEIJING AIMEIKE BIO-TECH CO., LTD. (CN) | 2013-08-22 | — | — | US | claimed |
| US-8475758-B2 | Low cost routes to high purity silicon and derivatives thereof | MAYATERIALS, INC. (US) | 2013-07-02 | — | — | US | claimed |
| US-8024943-B2 | Method of dividing glass into separate pieces with the aid of a cutting liquid and improved cutting liquid for said method | SCHOTT AG (DE) | 2011-09-27 | — | — | US | claimed |
| US-20110206592-A1 | LOW COST ROUTES TO HIGH PURITY SILICON AND DERIVATIVES THEREOF | LAINE, RICHARD M | 2011-08-25 | — | — | US | claimed |
| EP-2321221-A2 | LOW COST ROUTES TO HIGH PURITY SILICON AND DERIVATIVES THEREOF | Mayaterials, Inc. (US) | 2011-05-18 | — | — | EP | claimed |
| WO-2010017364-A2 | LOW COST ROUTES TO HIGH PURITY SILICON AND DERIVATIVES THEREOF | MAYATERIALS, INC. (US) | 2010-02-11 | — | — | WO | claimed |
| EP-1726635-B1 | Process for severing glass and use of the cutting fluid suitable therefor | SCHOTT AG (DE) | 2009-09-02 | — | — | EP | claimed |
| US-20060266195-A1 | Method of dividing glass into separate pieces with the aid of a cutting liquid and improved cutting liquid for said method | SCHOTT AG (DE) | 2006-11-30 | — | — | US | claimed |
| US-4169853-A | HYDROGENATION, CATALYST SELECTIVITY | TEXACO DEVELOPMENT CORPORATION (US) | 1979-10-02 | — | — | US | claimed |
| CN-115124049-B | Method for synthesizing FER zeolite nano-sheet with controllable thickness by using small molecular template agent | 浙江大学 | 2023-07-21 | — | — | CN | disclosed |
| CN-115124049-A | Method for synthesizing FER zeolite nanosheet with controllable thickness by using small-molecule template agent | 浙江大学 | 2022-09-30 | — | — | CN | disclosed |
| EP-2321221-B1 | LOW COST ROUTES TO HIGH PURITY SILICON AND DERIVATIVES THEREOF | MAYATERIALS INC (US) | 2017-03-15 | — | — | EP | disclosed |
| US-20160310522-A1 | METHOD FOR PRODUCING COMPOSITE GEL BY CROSS-LINKING HYALURONIC ACID AND HYDROXYLPROPYL METHYLCELLULOSE | AiMeike Technology Deveolpment., LTD | 2016-10-27 | — | — | US | disclosed |
| EP-1568744-A1 | COMPOSITION FOR POROUS FILM FORMATION, POROUS FILM, PROCESS FOR PRODUCING THE SAME, INTERLAYER INSULATION FILM AND SEMICONDUCTOR DEVICE | MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) | 2005-08-31 | — | — | EP | disclosed |
| US-20050090688-A1 | Metallized mesoporous silicate and method of oxidation with the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2005-04-28 | — | — | US | disclosed |
| US-20040219372-A1 | Composition for forming porous film, porous film and method for forming the same, interlevel insulator film, and semiconductor device | MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. | 2004-11-04 | — | — | US | disclosed |
| EP-1473275-A1 | METALLIZED MESOPOROUS SILICATE AND METHOD OF OXIDATION WITH THE SAME | Sumitomo Chemical Company, Limited (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-4169853-A | HYDROGENATION, CATALYST SELECTIVITY | TEXACO DEVELOPMENT CORPORATION (US) | 1979-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160310522-A1 | METHOD FOR PRODUCING COMPOSITE GEL BY CROSS-LINKING HYALURONIC ACID AND HYDROXYLPROPYL METHYLCELLULOSE | CD44, HAAO, HPGDS | OPRM1 2140/4885THRB 4691/4885GRIK1 3390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.