Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | XBP1 | P17861 | 1/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18038969 | 0.90 | PTGDR2 (0.44) | SMN1; SMN2LMNANPSR1MAPTHTT | |
| SCHEMBL18038967 | 0.81 | GAA (0.47) | SMN1; SMN2LMNAMAPTHTTGAA | |
| SCHEMBL30207105 | 0.81 | GAA (0.47) | SMN1; SMN2LMNAMAPTHTTGAA | |
| SCHEMBL18039019 | 0.81 | LMNA (0.53) | SMN1; SMN2LMNAMAPTHTTGAA | |
| SCHEMBL18054903 | 0.81 | ALDH1A1 (0.45) | SMN1; SMN2LMNANPSR1MAPTGAA | |
| SCHEMBL18038998 | 0.81 | GAA (0.46) | SMN1; SMN2LMNAMAPTHTTGAA | |
| SCHEMBL22051931 | 0.78 | GAA (0.42) | SMN1; SMN2LMNAMAPTHTTGAA | |
| SCHEMBL22050486 | 0.76 | USP5 (0.51) | LMNAMAPTHTTGAAALDH1A1 | |
| SCHEMBL22051935 | 0.76 | USP5 (0.51) | LMNAMAPTHTTGAAALDH1A1 | |
| SCHEMBL22050495 | 0.73 | GAA (0.44) | SMN1; SMN2LMNAMAPTHTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11311523-B2 | Pyridinone compound and use thereof | KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION (JP) | 2022-04-26 | — | — | US | disclosed |
| EP-3692992-A1 | METHOD OF SCREENING DOCK1-SELECTIVE INHIBITORS FOR CANCER TREATMENT | Kyushu University National University Corporation (JP) | 2020-08-12 | — | — | EP | disclosed |
| EP-3263133-B1 | PYRIDINONE COMPOUND AND USE THEREOF | UNIV KYUSHU NAT UNIV CORP (JP) | 2020-04-01 | — | — | EP | disclosed |
| US-20200061039-A1 | PYRIDINONE COMPOUND AND USE THEREOF | KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION (JP) | 2020-02-27 | — | — | US | disclosed |
| US-10406141-B2 | Pyridinone compound and use thereof | KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION (JP) | 2019-09-10 | — | — | US | disclosed |
| US-20180028515-A1 | PYRIDINONE COMPOUND AND USE THEREOF | KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION (JP) | 2018-02-01 | — | — | US | disclosed |
| EP-3263133-A1 | PYRIDINONE COMPOUND AND USE THEREOF | Kyushu University, National University Corporation (JP) | 2018-01-03 | — | — | EP | disclosed |
| WO-2016136985-A1 | PYRIDINONE COMPOUND AND USE THEREOF | 国立大学法人九州大学 | 2016-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180028515-A1 | PYRIDINONE COMPOUND AND USE THEREOF | DOCK5, DOCK2, CIB1 | SMN1; SMN2 2842/4885LMNA 3330/4885NPSR1 2475/4885 |
| US-20200061039-A1 | PYRIDINONE COMPOUND AND USE THEREOF | DOCK5, DOCK2, CIB1 | SMN1; SMN2 2818/4885LMNA 3349/4885NPSR1 2408/4885 |
| US-10406141-B2 | Pyridinone compound and use thereof | DOCK5, DOCK2, CIB1 | SMN1; SMN2 2842/4885LMNA 3330/4885NPSR1 2475/4885 |
| US-11311523-B2 | Pyridinone compound and use thereof | DOCK5, DOCK2, CIB1 | SMN1; SMN2 2818/4885LMNA 3349/4885NPSR1 2408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.