Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 15/20 | 0.46 |
| ▸ | CA9 | Q16790 | 14/20 | 0.46 |
| ▸ | CA12 | O43570 | 13/20 | 0.46 |
| ▸ | CA1 | P00915 | 13/20 | 0.45 |
| ▸ | CA7 | P43166 | 9/20 | 0.45 |
| ▸ | CA5A | P35218 | 7/20 | 0.45 |
| ▸ | CA5B | Q9Y2D0 | 7/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 7/20 | 0.45 |
| ▸ | CA6 | P23280 | 6/20 | 0.45 |
| ▸ | CA4 | P22748 | 6/20 | 0.45 |
| ▸ | CA13 | Q8N1Q1 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323422 | 0.81 | CA2 (0.52) | CA2CA9CA12CA1CA7 | |
| SCHEMBL9827832 | 0.81 | SLC18A3 (0.52) | MEN1KMT2ACA2CA9CA12 | |
| SCHEMBL6841898 | 0.78 | CHRNA7 (0.59) | CA2CA9CA12CA1CA7 | |
| SCHEMBL25252933 | 0.77 | HTR6 (0.52) | TSHR | |
| SCHEMBL14341830 | 0.76 | LMNA (0.59) | CA2CA9CA12CA1CA7 | |
| Hydrochloric Acid SCHEMBL31638148 | 0.76 | PKM (0.37) | TSHRKDM4ELMNAHTT | |
| SCHEMBL25254858 | 0.76 | LMNA (0.45) | ALDH1A1LMNAHTT | |
| SCHEMBL28820844 | 0.74 | CA2 (0.47) | MEN1KMT2ACA2CA9CA12 | |
| SCHEMBL9494422 | 0.74 | LMNA (0.57) | CA2CA9CA12CA1CA7 | |
| SCHEMBL25325992 | 0.74 | PKM (0.36) | MEN1KMT2ATSHRALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035371-B1 | SUBSTITUTED PHENYL METHANONE DERIVATIVES AND THEIR USE AS GLYT1 AND GLYT2 RECEPTOR INHIBITORS | HOFFMANN LA ROCHE (CH) | 2013-03-06 | — | — | EP | disclosed |
| US-7951836-B2 | Substituted phenyl methanone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |
| US-20070299071-A1 | Substituted phenyl methanone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299071-A1 | Substituted phenyl methanone derivatives | CYP11B1, CYP11B2, MC2R | MEN1 760/4885KMT2A 1401/4885CA2 3246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.