Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | BMI1 | P35226 | 3/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.32 |
| ▸ | RECQL | P46063 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22617646 | 0.80 | KDM4E (0.35) | ALDH1A1KDM4EHPGDMEN1MAPT | |
| SCHEMBL18156768 | 0.79 | PSMD14 (0.35) | ALDH1A1KDM4EHPGDMEN1MAPT | |
| SCHEMBL18314568 | 0.78 | PSMD14 (0.34) | ALDH1A1KDM4EHPGDMEN1MAPT | |
| SCHEMBL17470615 | 0.77 | PDE10A (0.37) | ALDH1A1KDM4EHPGDMEN1MAPT | |
| SCHEMBL19315362 | 0.76 | ALDH1A1 (0.37) | ALDH1A1KDM4EHPGDMEN1MAPT | |
| SCHEMBL23894908 | 0.76 | PPARG (0.33) | PDE10A | |
| SCHEMBL23894921 | 0.75 | — | — | |
| SCHEMBL27250599 | 0.75 | PDE10A (0.41) | ALDH1A1KDM4EHPGDMEN1MAPT | |
| SCHEMBL18156779 | 0.75 | RECQL (0.38) | ALDH1A1MEN1MAPTKMT2APDE10A | |
| SCHEMBL15394561 | 0.74 | PSMD14 (0.41) | ALDH1A1KDM4EHPGDMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230126850-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2023-04-27 | — | — | US | disclosed |
| US-20230126850-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2023-04-27 | — | — | US | disclosed |
| US-11545634-B2 | Heterocyclic spiro compounds | MERCK PATENT GMBH (DE) | 2023-01-03 | — | — | US | disclosed |
| EP-3330262-B1 | HETEROCYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DIODE CONTAINING SAME | LG CHEMICAL LTD (KR) | 2021-07-28 | — | — | EP | disclosed |
| US-10822330-B2 | Heterocyclic compound and organic light emitting diode containing same | LG CHEM, LTD. (KR) | 2020-11-03 | — | — | US | disclosed |
| EP-3708634-A1 | HETEROCYCLIC SPIRO COMPOUNDS | Merck Patent GmbH (DE) | 2020-09-16 | — | — | EP | disclosed |
| US-10777750-B2 | Heterocyclic spiro compounds | BASF SE (DE) | 2020-09-15 | — | — | US | disclosed |
| US-20200266364-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2020-08-20 | — | — | US | disclosed |
| EP-3083880-B1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2020-04-01 | — | — | EP | disclosed |
| US-20160308147-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | US | disclosed |
| US-20160308147-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160308147-A1 | HETEROCYCLIC SPIRO COMPOUNDS | NES, KCNC1, HCN4 | ALDH1A1 383/4885KDM4E 4246/4885HPGD 736/4885 |
| US-11545634-B2 | Heterocyclic spiro compounds | NES, KCNC1, HCN4 | ALDH1A1 383/4885KDM4E 4246/4885HPGD 736/4885 |
| US-20200266364-A1 | HETEROCYCLIC SPIRO COMPOUNDS | NES, KCNC1, HCN4 | ALDH1A1 383/4885KDM4E 4246/4885HPGD 736/4885 |
| US-10822330-B2 | Heterocyclic compound and organic light emitting diode containing same | CRY1, CRY2, PER2 | ALDH1A1 270/4885KDM4E 2233/4885HPGD 1474/4885 |
| US-20230126850-A1 | HETEROCYCLIC SPIRO COMPOUNDS | NES, KCNC1, HCN4 | ALDH1A1 383/4885KDM4E 4246/4885HPGD 736/4885 |
| US-10777750-B2 | Heterocyclic spiro compounds | NES, KCNC1, HCN4 | ALDH1A1 383/4885KDM4E 4246/4885HPGD 736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.