Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 1/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.59 |
| ▸ | HTR7 | P34969 | 1/20 | 0.59 |
| ▸ | HTR2B | P41595 | 1/20 | 0.59 |
| ▸ | HTR6 | P50406 | 1/20 | 0.59 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.57 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.57 |
| ▸ | SPR | P35270 | 1/20 | 0.55 |
| ▸ | CNR1 | P21554 | 6/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18189688 | 0.84 | ALDH1A1 (0.58) | SNCAMTNR1AMTNR1BSPRCNR1 | |
| SCHEMBL18509842 | 0.83 | ADRA2A (0.62) | SNCAADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL29724709 | 0.83 | SNCA (0.57) | SNCAADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL20242466 | 0.80 | PABPC1 (0.75) | HTR6MTNR1AMTNR1BPOLBMAPT | |
| SCHEMBL1757962 | 0.80 | KDM4E (0.73) | ADRA2AADRA2BADRA2CHTR7HTR2B | |
| SCHEMBL30867192 | 0.80 | HTR7 (0.68) | SNCAADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL18189687 | 0.80 | MTNR1A (0.52) | SNCAMTNR1AMTNR1BSPRCNR1 | |
| SCHEMBL3232684 | 0.78 | MAPT (0.69) | SNCAMTNR1AMTNR1BSPRCNR1 | |
| SCHEMBL6580121 | 0.78 | MTNR1A (0.51) | MTNR1AMTNR1BSPRPOLBMAPT | |
| SCHEMBL28750432 | 0.77 | HTR6 (0.68) | ADRA2AADRA2BADRA2CHTR7HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288921-B1 | POLYCYCLIC INDOLINE AND INDOLENINE COMPOUNDS | UNIV COLORADO REGENTS (US) | 2022-06-15 | — | — | EP | disclosed |
| US-10253024-B2 | Polycyclic indoline and indolenine compounds | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2019-04-09 | — | — | US | disclosed |
| US-20180148442-A1 | Polycyclic Indoline and Indolenine Compounds | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2018-05-31 | — | — | US | disclosed |
| EP-3288921-A1 | POLYCYCLIC INDOLINE AND INDOLENINE COMPOUNDS | The Regents of the University of Colorado, a body corporate (US) | 2018-03-07 | — | — | EP | disclosed |
| WO-2016176634-A1 | POLYCYCLIC INDOLINE AND INDOLENINE COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2016-11-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10253024-B2 | Polycyclic indoline and indolenine compounds | IDO1, IDO2, INMT | SNCA 978/4885ADRA2A 1655/4885ADRA2B 1962/4885 |
| US-20180148442-A1 | Polycyclic Indoline and Indolenine Compounds | IDO1, IDO2, INMT | SNCA 978/4885ADRA2A 1655/4885ADRA2B 1962/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.