Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | EP300 | Q09472 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | GABRP | O00591 | 1/20 | 0.31 |
| ▸ | GABRD | O14764 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.31 |
| ▸ | GABRE | P78334 | 1/20 | 0.31 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.31 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18209727 | 0.86 | GABRP (0.41) | BRD4EP300CREBBPGABRPGABRD | |
| SCHEMBL18209687 | 0.84 | TMEM97 (0.49) | TMEM97SIGMAR1BRD4EP300CREBBP | |
| SCHEMBL18325699 | 0.72 | ALDH1A1 (0.40) | PTPN1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL21562972 | 0.71 | GABRP (0.34) | PTPN1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL21995862 | 0.71 | GABRP (0.37) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL17338781 | 0.69 | PDE4D (0.30) | — | |
| SCHEMBL18325701 | 0.68 | GABRP (0.35) | PTPN1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL23646937 | 0.68 | MAPK1 (0.38) | PTPN1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL15708707 | 0.68 | LMNA (0.60) | ALDH1A1TSHR | |
| SCHEMBL14555805 | 0.68 | LMNA (0.39) | PTPN1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230041761-A1 | SMALL MOLECULE MODULATORS OF SIGMA-1 AND SIGMA-2 RECEPTORS AND USES THEREOF | NORTHWESTERN UNIVERSITY | 2023-02-09 | — | — | US | disclosed |
| WO-2020112846-A1 | SMALL MOLECULE MODULATORS OF SIGMA-1 AND SIGMA-2 RECEPTORS AND USES THEREOF | NORTHWESTERN UNIVERSITY (US) | 2020-06-04 | — | — | WO | disclosed |
| US-20200039941-A1 | CXCR4 CHEMOKINE RECEPTOR MODULATORS | NATIONAL INSTITUTES OF HEALTH | 2020-02-06 | — | — | US | disclosed |
| US-20200039941-A1 | CXCR4 CHEMOKINE RECEPTOR MODULATORS | NATIONAL INSTITUTES OF HEALTH | 2020-02-06 | — | — | US | disclosed |
| US-10435375-B2 | CXCR4 chemokine receptor modulators | NORTHWESTERN UNIVERSITY (US) | 2019-10-08 | — | — | US | disclosed |
| US-10435375-B2 | CXCR4 chemokine receptor modulators | NORTHWESTERN UNIVERSITY (US) | 2019-10-08 | — | — | US | disclosed |
| US-20180155295-A1 | CXCR4 CHEMOKINE RECEPTOR MODULATORS | NORTHWESTERN UNIVERSITY | 2018-06-07 | — | — | US | disclosed |
| US-20180155295-A1 | CXCR4 CHEMOKINE RECEPTOR MODULATORS | NORTHWESTERN UNIVERSITY | 2018-06-07 | — | — | US | disclosed |
| US-20180155295-A1 | CXCR4 CHEMOKINE RECEPTOR MODULATORS | NORTHWESTERN UNIVERSITY | 2018-06-07 | — | — | US | disclosed |
| WO-2016179349-A1 | CXCR4 CHEMOKINE RECEPTOR MODULATORS | NORTHWESTERN UNIVERSITY (US) | 2016-11-10 | — | — | WO | disclosed |
| WO-2016179349-A1 | CXCR4 CHEMOKINE RECEPTOR MODULATORS | NORTHWESTERN UNIVERSITY (US) | 2016-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10435375-B2 | CXCR4 chemokine receptor modulators | CXCR4, ACKR3, CXCR3 | PTPN1 1158/4885TMEM97 323/4885SIGMAR1 354/4885 |
| US-20180155295-A1 | CXCR4 CHEMOKINE RECEPTOR MODULATORS | CXCR4, ACKR3, CXCR3 | PTPN1 1158/4885TMEM97 323/4885SIGMAR1 354/4885 |
| US-20230041761-A1 | SMALL MOLECULE MODULATORS OF SIGMA-1 AND SIGMA-2 RECEPTORS AND USES THEREOF | SIGMAR1, TMEM97, OPRM1 | PTPN1 2866/4885TMEM97 2/4885SIGMAR1 1/4885 |
| US-20200039941-A1 | CXCR4 CHEMOKINE RECEPTOR MODULATORS | CXCR4, ACKR3, CXCR3 | PTPN1 1158/4885TMEM97 323/4885SIGMAR1 354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.