Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 15/20 | 0.72 |
| ▸ | TP53 | P04637 | 3/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6402138 | 0.91 | TRPM8 (0.76) | TRPM8 | |
| SCHEMBL18251889 | 0.89 | LMNA (0.69) | TRPM8POLBLMNA | |
| SCHEMBL18251891 | 0.89 | TRPM8 (0.64) | TRPM8 | |
| SCHEMBL18251888 | 0.86 | TRPM8 (0.59) | TRPM8TP53POLBLMNATHRB | |
| SCHEMBL17230197 | 0.85 | TRPM8 (0.84) | TRPM8TP53POLBLMNATHRB | |
| SCHEMBL2717660 | 0.84 | TRPM8 (0.83) | TRPM8TP53POLBLMNATHRB | |
| SCHEMBL18251890 | 0.84 | TP53 (0.74) | TRPM8TP53LMNA | |
| SCHEMBL20640704 | 0.84 | TRPM8 (1.00) | TRPM8TP53POLBLMNATHRB | |
| SCHEMBL30828339 | 0.84 | TP53 (0.74) | TRPM8TP53LMNA | |
| SCHEMBL25262665 | 0.83 | TRPM8 (0.55) | TRPM8TP53POLBLMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025202256-A1 | COOLING COMPOSITION | FIRMENICH SA (CH) | 2025-10-02 | — | — | WO | disclosed |
| CN-110869365-B | Cooling composition | 弗门尼舍有限公司 | 2024-03-29 | — | — | CN | disclosed |
| US-11871772-B2 | Antagonists of T2R54 and compositions and uses thereof | FIRMENICH INCORPORATED (US) | 2024-01-16 | — | — | US | disclosed |
| US-11174249-B2 | Cooling composition | FIRMENICH SA (CH) | 2021-11-16 | — | — | US | disclosed |
| EP-3652171-B1 | COOLING COMPOSITIONS CONTAINING AN AMIDE AND AN ALKYL LACTATE | FIRMENICH & CIE (CH) | 2021-09-08 | — | — | EP | disclosed |
| CN-108473484-B | Compounds useful as TRPM8 modulators | 弗门尼舍公司 | 2021-06-29 | — | — | CN | disclosed |
| EP-3356356-B1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED (US) | 2021-05-26 | — | — | EP | disclosed |
| EP-3356356-B1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED (US) | 2021-05-26 | — | — | EP | disclosed |
| US-20200157083-A1 | COOLING COMPOSITION | FIRMENICH SA (CH) | 2020-05-21 | — | — | US | disclosed |
| EP-3652171-A1 | COOLING COMPOSITION | Firmenich SA (CH) | 2020-05-20 | — | — | EP | disclosed |
| US-20190177308-A9 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. | 2019-06-13 | — | — | US | disclosed |
| US-20190177308-A9 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. | 2019-06-13 | — | — | US | disclosed |
| WO-2019012071-A1 | COOLING COMPOSITION | FIRMENICH SA (CH) | 2019-01-17 | — | — | WO | disclosed |
| US-20180273517-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX INC (US) | 2018-09-27 | — | — | US | disclosed |
| US-9732071-B2 | Compounds useful as modulators of TRPM8 | SENOMYX, INC. (US) | 2017-08-15 | — | — | US | disclosed |
| US-9732071-B2 | Compounds useful as modulators of TRPM8 | SENOMYX, INC. (US) | 2017-08-15 | — | — | US | disclosed |
| US-20170096418-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED | 2017-04-06 | — | — | US | disclosed |
| US-20170096418-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED | 2017-04-06 | — | — | US | disclosed |
| US-20170087199-A1 | COMPOSITIONS FOR DELIVERING A COOLING SENSATION | SENOMYX INC (US) | 2017-03-30 | — | — | US | disclosed |
| US-20160339026-A1 | TOPICAL COMPOSITIONS COMPRISING MODULATORS OF TRPM8 | SENOMYX INC (US) | 2016-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11871772-B2 | Antagonists of T2R54 and compositions and uses thereof | TAS2R50, TAS2R30, TAS2R60 | TRPM8 46/4885TP53 2631/4885POLB 4811/4885 |
| US-20200157083-A1 | COOLING COMPOSITION | LDHA, LDHB, ADH1A | TRPM8 1016/4885TP53 1460/4885POLB 425/4885 |
| US-20190177308-A9 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM6, TRPM4 | TRPM8 1/4885TP53 3839/4885POLB 4236/4885 |
| US-20180273517-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM6, TRPM4 | TRPM8 1/4885TP53 3839/4885POLB 4236/4885 |
| US-20170087199-A1 | COMPOSITIONS FOR DELIVERING A COOLING SENSATION | TRPA1, PDE6G, PDE6D | TRPM8 97/4885TP53 3741/4885POLB 3252/4885 |
| US-11174249-B2 | Cooling composition | LDHA, LDHB, ADH1A | TRPM8 1016/4885TP53 1460/4885POLB 425/4885 |
| US-20160339026-A1 | TOPICAL COMPOSITIONS COMPRISING MODULATORS OF TRPM8 | TRPM8, TRPM7, TRPM2 | TRPM8 1/4885TP53 1662/4885POLB 2854/4885 |
| US-20170096418-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM6, TRPM4 | TRPM8 1/4885TP53 3839/4885POLB 4236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.