Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.52 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.51 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.49 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.48 |
| ▸ | PPARG | P37231 | 7/20 | 0.48 |
| ▸ | PPARD | Q03181 | 7/20 | 0.48 |
| ▸ | PPARA | Q07869 | 7/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TLR2 | O60603 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | FABP4 | P15090 | 2/20 | 0.48 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.48 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17010716 | 1.00 | NAAA (0.52) | NAAAFFAR4FFAR1PLA2G2CGPR84 | |
| SCHEMBL17010718 | 1.00 | NAAA (0.52) | NAAAFFAR4FFAR1PLA2G2CGPR84 | |
| SCHEMBL16553093 | 0.93 | TET2 (0.47) | FFAR4FFAR1GPR84PPARGPPARD | |
| SCHEMBL28591540 | 0.86 | NAAA (0.61) | NAAAMEN1KMT2A | |
| SCHEMBL31648087 | 0.86 | NAAA (0.61) | NAAAMEN1KMT2A | |
| SCHEMBL28591704 | 0.86 | NAAA (0.61) | NAAAMEN1KMT2A | |
| SCHEMBL9220597 | 0.85 | NAAA (0.59) | NAAAFFAR1GPR84TSHR | |
| SCHEMBL13002969 | 0.85 | GPR84 (0.59) | NAAAFFAR1GPR84TSHR | |
| SCHEMBL8375622 | 0.85 | GPR84 (0.59) | NAAAFFAR1GPR84TSHR | |
| SCHEMBL6864319 | 0.85 | GPR84 (0.59) | NAAAFFAR1GPR84TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190133980-A1 | Compositions and methods for targeting and treating homologous recombination-deficient tumors | UNIV YALE (US) | 2019-05-09 | — | — | US | claimed |
| US-20160354334-A1 | Compositions and Methods for Treating Aging and Age-Related Diseases and Symptoms | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-12-08 | — | — | US | claimed |
| EP-3104852-B1 | COMPOSITIONS AND METHODS FOR TREATING AGING AND AGE-RELATED DISEASES AND SYMPTOMS | UNIV CALIFORNIA (US) | 2024-08-14 | — | — | EP | disclosed |
| US-20230218559-A1 | Compositions and Methods for Treating Aging and Age-Related Diseases and Symptoms | UNIV CALIFORNIA (US) | 2023-07-13 | — | — | US | disclosed |
| EP-3535025-B1 | COMPOSITION COMPRISING R-2-HYDROXYGLUTARATE AND ONE AGENT THAT INHIBITS MYC SIGNALING FOR TREATING CANCER | UNIV CINCINNATI (US) | 2023-06-28 | — | — | EP | disclosed |
| US-20230144845-A1 | Alpha-Ketobutyrate, 2-Hydroxybutyrate, and Alpha-Ketoglutarate for Stimulating Hair Growth | UNIV CALIFORNIA (US) | 2023-05-11 | — | — | US | disclosed |
| US-11179360-B2 | Compositions and methods for treating patients suffering from glioma or leukemia | UNIVERSITY OF CINCINNATI (US) | 2021-11-23 | — | — | US | disclosed |
| US-11007163-B2 | Glutarate compounds for treating ischemia-reperfusion injuries | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-05-18 | — | — | US | disclosed |
| US-20200253907-A1 | Compositions and Methods for Treating Neurodegenerative Diseases | UNIV CALIFORNIA (US) | 2020-08-13 | — | — | US | disclosed |
| EP-3672583-A1 | COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES | The Regents of the University of California (US) | 2020-07-01 | — | — | EP | disclosed |
| US-20200069621-A1 | Glutarate Compounds for Treating Ischemia-Reperfusion Injuries | UNIV CALIFORNIA (US) | 2020-03-05 | — | — | US | disclosed |
| US-10285962-B2 | Glutarate compounds for treating ischemia-reperfusion injuries | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-05-14 | — | — | US | disclosed |
| US-20190133980-A1 | Compositions and methods for targeting and treating homologous recombination-deficient tumors | UNIV YALE (US) | 2019-05-09 | — | — | US | disclosed |
| EP-3453046-A1 | GLUTARATE COMPOUNDS FOR TREATING ISCHEMIA-REPERFUSION INJURIES | The Regents of the University of California (US) | 2019-03-13 | — | — | EP | disclosed |
| WO-2019038655-A1 | COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-02-28 | — | — | WO | disclosed |
| WO-2018064468-A1 | ALPHA-KETOBUTYRATE, ALPHA-KETOGLUTARATE, AND 2-HYDROXYBUTYRATE FOR STIMULATING HAIR GROWTH | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-04-05 | — | — | WO | disclosed |
| WO-2017210608-A1 | COMPOSITIONS AND METHODS FOR TARGETING AND TREATING HOMOLOGOUS RECOMBINATION-DEFICIENT TUMORS | YALE UNIVERSITY (US) | 2017-12-07 | — | — | WO | disclosed |
| US-20170333373-A1 | Glutarate Compounds for Treating Ischemia-Reperfusion Injuries | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2017-11-23 | — | — | US | disclosed |
| WO-2017192413-A1 | GLUTARATE COMPOUNDS FOR TREATING ISCHEMIA-REPERFUSION INJURIES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-11-09 | — | — | WO | disclosed |
| US-20160354334-A1 | Compositions and Methods for Treating Aging and Age-Related Diseases and Symptoms | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200069621-A1 | Glutarate Compounds for Treating Ischemia-Reperfusion Injuries | GCDH, OGDH, GLS | NAAA 2735/4885FFAR4 1359/4885FFAR1 673/4885 |
| US-20160354334-A1 | Compositions and Methods for Treating Aging and Age-Related Diseases and Symptoms | GLA, GCDH, HAGH | NAAA 595/4885FFAR4 3002/4885FFAR1 2528/4885 |
| US-11007163-B2 | Glutarate compounds for treating ischemia-reperfusion injuries | GCDH, OGDH, GLS | NAAA 2735/4885FFAR4 1359/4885FFAR1 673/4885 |
| US-20200253907-A1 | Compositions and Methods for Treating Neurodegenerative Diseases | SNCA, PSEN2, PSEN1 | NAAA 221/4885FFAR4 3725/4885FFAR1 2888/4885 |
| US-20170333373-A1 | Glutarate Compounds for Treating Ischemia-Reperfusion Injuries | GCDH, OGDH, GLS | NAAA 2735/4885FFAR4 1359/4885FFAR1 673/4885 |
| US-20230218559-A1 | Compositions and Methods for Treating Aging and Age-Related Diseases and Symptoms | GCDH, GLA, GRHPR | NAAA 805/4885FFAR4 2783/4885FFAR1 2219/4885 |
| US-20230144845-A1 | Alpha-Ketobutyrate, 2-Hydroxybutyrate, and Alpha-Ketoglutarate for Stimulating Hair Growth | HOGA1, GCDH, LDHB | NAAA 2263/4885FFAR4 1617/4885FFAR1 1075/4885 |
| US-11179360-B2 | Compositions and methods for treating patients suffering from glioma or leukemia | MYC, IDH1, OGDH | NAAA 2650/4885FFAR4 4042/4885FFAR1 3543/4885 |
| US-10285962-B2 | Glutarate compounds for treating ischemia-reperfusion injuries | GCDH, OGDH, GLS | NAAA 2735/4885FFAR4 1359/4885FFAR1 673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.