SCHEMBL18316

SCHEMBL18316

O=S(=O)(Cl)c1ccc(Cl)c(Cl)c1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APEX1 P27695 1/20 0.50
HSD17B10 Q99714 2/20 0.44
ALDH1A1 P00352 2/20 0.44
TDP1 Q9NUW8 1/20 0.44
CA12 O43570 1/20 0.43
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
CA4 P22748 1/20 0.43
CA6 P23280 1/20 0.43
CA5A P35218 1/20 0.43
CA7 P43166 1/20 0.43
CA9 Q16790 1/20 0.43
CA14 Q9ULX7 1/20 0.43
CA5B Q9Y2D0 1/20 0.43
NFE2L2 Q16236 1/20 0.42
FLT1 P17948 1/20 0.42
FLT4 P35916 1/20 0.42
KDR P35968 1/20 0.42
PTGES2 Q9H7Z7 1/20 0.42
RAB9A P51151 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7003118 0.98 APEX1 (0.48) APEX1HSD17B10ALDH1A1TDP1CA12
SCHEMBL6893360 0.86 KMT2A (0.41) APEX1ALDH1A1TDP1CA1CA2
SCHEMBL1019304 0.82 AHR (0.58) APEX1HSD17B10ALDH1A1TDP1CA12
SCHEMBL30343460 0.82 MAPT (0.54) APEX1HSD17B10ALDH1A1CA12CA1
SCHEMBL2679084 0.82 MAPT (0.54) APEX1HSD17B10ALDH1A1CA12CA1
SCHEMBL7124035 0.81 POLB (0.47) APEX1HSD17B10ALDH1A1TDP1CA12
SCHEMBL11427098 0.81 TRPV4 (0.55) APEX1HSD17B10ALDH1A1TDP1CA12
SCHEMBL6888545 0.80 PKM (0.44) APEX1TDP1PTGES2
SCHEMBL5913739 0.80 APEX1 (0.50) APEX1HSD17B10ALDH1A1CA12CA1
SCHEMBL2649250 0.79 PTGS1 (0.51) HSD17B10ALDH1A1TDP1CA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1441 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119565410-A Seawater desalination reverse osmosis membrane, preparation method and application 湖南澳维膜科技有限公司 2025-03-07 CN claimed
CN-117486670-B Synthesis method of 3,4, 5-trifluoro-bromobenzene 山东国邦药业有限公司 2024-03-12 CN claimed
CN-117486670-A Synthesis method of 3,4, 5-trifluoro-bromobenzene 山东国邦药业有限公司 2024-02-02 CN claimed
WO-2013102936-A1 N-(3-((DIETHYLAMINO) METHYL)-4-HYDROXYPHENYL)-N-(QUINOLIN-4-YL) SULFONAMIDES FOR THE TREATMENT OF TUBERCULOSIS AND PROCESS OF PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2013-07-11 WO claimed
EP-1506176-B1 AMINOINDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM PFIZER ITALIA SRL (IT) 2013-04-24 EP claimed
EP-2385831-A2 SMALL MOLECULE INHIBITORS OF NADS, NAMNAT, AND NMNAT The UAB Research Foundation (US) 2011-11-16 EP claimed
US-20110254866-A1 INFORMATION PROCESSING APPARATUS, METHOD AND PROGRAM THEREFORE SONY CORPORATION (JP) 2011-10-20 US claimed
WO-2010123591-A2 SMALL MOLECULE INHIBITORS OF NADS, NAMNAT, AND NMNAT THE UAB RESEARCH FOUNDATION (US) 2010-10-28 WO claimed
EP-1377589-B1 OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS PHARMACIA ITALIA SPA (IT) 2005-09-07 EP claimed
US-5710355-A Method of making chlorobenzenes OCCIDENTAL CHEMICAL CORPORATION (US) 1998-01-20 US claimed
US-12630529-B2 GCN2 modulator compounds Alesta Therapeutics BV (NL) 2026-05-19 US disclosed
CN-117209426-B Nitidine-like sulfonamide derivative and preparation method and application thereof 广西中医药大学 2026-05-19 CN disclosed
US-20260062393-A1 Compounds CTXT PTY LTD (AU) 2026-03-05 US disclosed
EP-4204397-B1 INHIBITORS OF PSEUDOMONAS AERUGINOSA VIRULENCE FACTOR LASB HELMHOLTZ ZENTRUM INFEKTIONSFORSCHUNG GMBH (DE) 2025-12-03 EP disclosed
US-20250250265-A1 BENZOTHIAZOLE-PHENYLSULFONYL-PIPERIDINE ANALOGS AS ACTIVATORS OF NACYLPHOSPHATIDYLETHANOLAMINE HYDROLYZING PHOSPHOLIPASE D VANDERBILT UNIVERSITY 2025-08-07 US disclosed
US-4026798-A PROLONGING USE FMC CORPORATION (US) 1977-05-31 US disclosed
US-4013575-A Dry cleaning with peracids FMC CORPORATION (US) 1977-03-22 US disclosed
US-4002641-A DIURETICS, SALURETICS, HYPOTENSIVES BAYER AKTIENGESELLSCHAFT (DT) 1977-01-11 US disclosed
US-3994873-A Azo dyestuffs containing sulfonylamino-sulfonyl groups BAYER AKTIENGESELLSCHAFT (DT) 1976-11-30 US disclosed
US-3945992-A DISAZO DYES FOR POLYAMIDES BAYER AKTIENGESELLSCHAFT (DT) 1976-03-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12630529-B2 GCN2 modulator compounds NR3C1, GCN1, EIF2AK4 APEX1 2331/4885HSD17B10 733/4885ALDH1A1 4260/4885
US-20250250265-A1 BENZOTHIAZOLE-PHENYLSULFONYL-PIPERIDINE ANALOGS AS ACTIVATORS OF NACYLPHOSPHATIDYLETHANOLAMINE HYDROLYZING PHOSPHOLIPASE D PLD1, PLD2, NAPEPLD APEX1 2781/4885HSD17B10 3690/4885ALDH1A1 2820/4885
US-20260062393-A1 Compounds SCN2B, ABCB11, SCN1B APEX1 4650/4885HSD17B10 863/4885ALDH1A1 1864/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.