Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.33 |
| ▸ | FGF23 | Q9GZV9 | 1/20 | 0.33 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.33 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | GMNN | O75496 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6516708 | 1.00 | NFE2L2 (0.33) | NFE2L2FGF23TRIM24TRIM33KDM4E | |
| SCHEMBL19540178 | 0.85 | FGF23 (0.36) | NFE2L2FGF23TRIM24TRIM33KDM4E | |
| SCHEMBL1396860 | 0.85 | FGF23 (0.36) | NFE2L2FGF23TRIM24TRIM33KDM4E | |
| SCHEMBL93457 | 0.81 | ALDH1A1 (0.39) | NFE2L2FGF23TRIM24TRIM33KDM4E | |
| SCHEMBL29554163 | 0.81 | ALDH1A1 (0.39) | NFE2L2FGF23TRIM24TRIM33KDM4E | |
| SCHEMBL782094 | 0.81 | FGF23 (0.44) | NFE2L2FGF23KDM4EALDH1A1MAPT | |
| SCHEMBL25447214 | 0.81 | FGF23 (0.33) | NFE2L2FGF23TRIM24TRIM33KDM4E | |
| SCHEMBL12508936 | 0.81 | FGF23 (0.36) | NFE2L2FGF23TRIM24TRIM33KDM4E | |
| SCHEMBL19596554 | 0.81 | FGF23 (0.33) | NFE2L2FGF23TRIM24TRIM33KDM4E | |
| SCHEMBL24601141 | 0.81 | FGF23 (0.33) | NFE2L2FGF23TRIM24TRIM33KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11396505-B2 | Inhibitors of CaMKK2 and uses of same | NEW YORK UNIVERSITY (US) | 2022-07-26 | — | — | US | disclosed |
| US-20200369656-A1 | INHIBITORS OF CAMKK2 AND USES OF SAME | NEW YORK UNIVERSITY | 2020-11-26 | — | — | US | disclosed |
| US-9763940-B2 | Therapeutic use of P75 receptor antagonists | SANOFI (FR) | 2017-09-19 | — | — | US | disclosed |
| US-20170056400-A1 | NOVEL THERAPEUTIC USE OF P75 RECEPTOR ANTAGONISTS | SANOFI (FR) | 2017-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11396505-B2 | Inhibitors of CaMKK2 and uses of same | CAMKK2, CAMKK1, CAMK1 | NFE2L2 822/4885FGF23 3996/4885TRIM24 2387/4885 |
| US-20200369656-A1 | INHIBITORS OF CAMKK2 AND USES OF SAME | CAMKK2, CAMKK1, CAMK1 | NFE2L2 822/4885FGF23 3996/4885TRIM24 2387/4885 |
| US-20170056400-A1 | NOVEL THERAPEUTIC USE OF P75 RECEPTOR ANTAGONISTS | OPRL1, CHRNB2, OGFR | NFE2L2 3282/4885FGF23 2222/4885TRIM24 1830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.