Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.54 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | PDE6A | P16499 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11682124 | 0.90 | TSHR (0.68) | CRHBPCRHR2TSHRNR3C1CYP2C19 | |
| SCHEMBL10974928 | 0.86 | CRHBP (0.68) | CRHBPCRHR2TSHRNR3C1PTPN1 | |
| SCHEMBL28496421 | 0.84 | CYP2C19 (0.52) | CRHBPCRHR2TSHRNR3C1PTPN1 | |
| SCHEMBL20853609 | 0.81 | HTT (0.48) | CRHBPCRHR2TSHRMAOBNR1H2 | |
| SCHEMBL11685169 | 0.81 | NR3C1 (0.45) | CRHBPCRHR2TSHRNR3C1PTPN1 | |
| SCHEMBL1925718 | 0.79 | RAB9A (0.51) | CRHBPCRHR2TSHRPTGESKMT2A | |
| SCHEMBL11164170 | 0.79 | TSHR (0.68) | TSHRNR3C1CYP2C19NR1H2NR1H3 | |
| SCHEMBL43183 | 0.79 | TSHR (0.74) | CRHBPCRHR2TSHRNR3C1PTPN1 | |
| SCHEMBL9809629 | 0.78 | CRHBP (0.56) | CRHBPCRHR2TSHRNR3C1PTPN1 | |
| SCHEMBL11794806 | 0.78 | TSHR (0.55) | CRHBPCRHR2TSHRNR3C1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11767296-B2 | Heteroaryl compounds as kinase inhibitor | FUJIAN HAIXI PHARMACEUTICALS CO., LTD (CN) | 2023-09-26 | — | — | US | disclosed |
| WO-2019174601-A1 | HETEROARYL COMPOUNDS AS KINASE INHIBITOR | FUJIAN HAIXI PHARMACEUTICALS CO., LTD (CN) | 2019-09-19 | — | — | WO | disclosed |
| US-8859777-B2 | 4-fluoro-4-arylpiperdin-1-yl derivatives as mu opioid function moderators | KINENTIA BIOSCIENCES LLC (US) | 2014-10-14 | — | — | US | disclosed |
| US-20130045165-A1 | 4-FLUORO-4-ARYLPIPERDIN-1-YL DERIVATIVES AS MU OPIOID FUNCTION MODERATORS | KINENTIA BIOSCIENCES, LLC (US) | 2013-02-21 | — | — | US | disclosed |
| US-20110105544-A1 | CARBOXYLIC DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | CRYSTAX PHARMACEUTICALS, S.L. (ES) | 2011-05-05 | — | — | US | disclosed |
| US-7589095-B2 | 4-phenyl-pyrimidine-2-carbonitrile derivatives | N.V. ORGANON (NL) | 2009-09-15 | — | — | US | disclosed |
| US-7456195-B2 | Phenylglycinamide and pyridylglycinamide derivatives useful as anticoagulants | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-11-25 | — | — | US | disclosed |
| US-7456195-B2 | Phenylglycinamide and pyridylglycinamide derivatives useful as anticoagulants | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-11-25 | — | — | US | disclosed |
| US-7456195-B2 | Phenylglycinamide and pyridylglycinamide derivatives useful as anticoagulants | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-11-25 | — | — | US | disclosed |
| EP-1758870-B1 | 4-PHENYL-PYRIMIDINE-2-CARBONITRILE DERIVATIVES | ORGANON NV (NL) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007002313-A2 | PHENYLGLYCINAMIDE AND PYRIDYLGLYCINAMIDE DERIVATIVES USEFUL AS ANTICOAGULANTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-01-04 | — | — | WO | disclosed |
| EP-1479686-B1 | Process for the preparation of aniline boronic acids and derivatives thereof | ARCHIMICA GMBH (DE) | 2006-10-04 | — | — | EP | disclosed |
| CN-1810812-A | Silicon element-containing cationic chromophore and its derivative | UNIV DALIAN SCIENCE & ENG (CN) | 2006-08-02 | — | — | CN | disclosed |
| US-20050038287-A1 | Preparation of Anilineboronic acids and derivatives thereof | CLARIANT GMBH | 2005-02-17 | — | — | US | disclosed |
| EP-1479686-A1 | Process for the preparation of aniline boronic acids and derivatives thereof | Clariant GmbH (DE) | 2004-11-24 | — | — | EP | disclosed |
| US-6103912-A | OPTICAL INFRARED FILTERS COMPRISING PH SENSITIVE DYES | POLAROID CORPORATION (US) | 2000-08-15 | — | — | US | disclosed |
| EP-0553346-B1 | PHOTOGRAPHIC PRODUCTS AND PROCESSES | POLAROID CORP (US) | 1998-01-28 | — | — | EP | disclosed |
| US-5244771-A | Bridged indicator dyes used as light-absorbing, pH-sensitive optical filter agents in diffusion transfer | POLAROID CORPORATION (US) | 1993-09-14 | — | — | US | disclosed |
| EP-0553346-A1 | PHOTOGRAPHIC PRODUCTS AND PROCESSES | POLAROID CORPORATION (US) | 1993-08-04 | — | — | EP | disclosed |
| WO-1993004403-A1 | PHOTOGRAPHIC PRODUCTS AND PROCESSES | POLAROID CORPORATION (US) | 1993-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11767296-B2 | Heteroaryl compounds as kinase inhibitor | RET, ERBB2, ABL1 | CRHBP 4540/4885CRHR2 2129/4885TSHR 369/4885 |
| US-20050038287-A1 | Preparation of Anilineboronic acids and derivatives thereof | C9, BLVRB, CBR3 | CRHBP 3496/4885CRHR2 1085/4885TSHR 714/4885 |
| US-20130045165-A1 | 4-FLUORO-4-ARYLPIPERDIN-1-YL DERIVATIVES AS MU OPIOID FUNCTION MODERATORS | OPRD1, OPRK1, OPRM1 | CRHBP 1702/4885CRHR2 1902/4885TSHR 282/4885 |
| US-20110105544-A1 | CARBOXYLIC DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | AKR1C3, TPD52L2, HCCS | CRHBP 4401/4885CRHR2 1332/4885TSHR 1505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.