Water

Water

SCHEMBL1866439

C1COCCOCCOCCO1.C1COCCOCCOCCO1.O

nearest known ligand 0.86

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.46
TTR P02766 1/20 0.86
ALDH1A1 P00352 1/20 0.50
KMT2A Q03164 1/20 0.46
TSHR P16473 2/20 0.44
GAA P10253 2/20 0.36
KDM4E B2RXH2 1/20 0.36
CYP2C9 P11712 1/20 0.36
SMN1; SMN2 Q16637 4/20 0.33
LMNA P02545 3/20 0.33
CRHBP P24387 2/20 0.33
HTT P42858 2/20 0.33
CRHR2 Q13324 2/20 0.33
MGLL Q99685 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dioxane SCHEMBL103807 1.00
Dioxane SCHEMBL2832209 1.00 TTR (0.86) TTRALDH1A1MEN1KMT2ATSHR
Water SCHEMBL9161357 1.00 TTR (0.86) TTRALDH1A1MEN1KMT2ATSHR
Water SCHEMBL11426218 1.00 TTR (0.86) TTRALDH1A1MEN1KMT2ATSHR
Dioxane SCHEMBL15882140 1.00 TTR (0.86) TTRALDH1A1MEN1KMT2ATSHR
Dioxane SCHEMBL23090025 1.00 TTR (0.86) TTRALDH1A1MEN1KMT2ATSHR
Dioxane SCHEMBL5000306 0.94
Dioxane SCHEMBL21461950 0.94
Dioxane SCHEMBL27453498 0.94
Dioxane SCHEMBL6954886 0.94

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7935309-B2 Multi-transduction mechanism based microfluidic analyte sensors WORCESTER POLYTECHNIC INSTITUTE (US) 2011-05-03 US disclosed
US-20090220381-A1 IMAGEWISE PATTERNING OF FILMS AND DEVICES COMPRISING THE SAME NESTEC S.A. (CH) 2009-09-03 US disclosed
WO-2007059265-A2 IMAGEWISE PATTERNING OF FILMS AND DEVICES COMPRISING THE SAME WORCESTER POLYTECHNIC INSTITUTE (US) 2007-05-24 WO disclosed
US-20070042450-A1 Multi-transduction mechanism based microfluidic analyte sensors WORCESTER POLYTECHNIC INSTITUTE (US) 2007-02-22 US disclosed
WO-2006113440-A2 MULTI-TRANSDUCTION MECHANISM BASED MICROFLUIDIC ANALYTE SENSORS WORCESTER POLYTECHNIC INSTITUTE (US) 2006-10-26 WO disclosed