SCHEMBL18667686

SCHEMBL18667686

c1ccc2cc3c(cc2c1)c1c2ccccc2c2ccccc2c1n3-c1ccncc1

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAPK10 P53779 9/20 0.38
MAPK9 P45984 8/20 0.38
MAPK8 P45983 2/20 0.38
MEN1 O00255 1/20 0.36
HSP90AA1 P07900 1/20 0.36
MAPT P10636 1/20 0.36
KMT2A Q03164 1/20 0.36
ALDH1A1 P00352 3/20 0.35
KDM4E B2RXH2 1/20 0.35
HPGD P15428 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
MAPK1 P28482 1/20 0.33
TOP2A P11388 1/20 0.33
MAT2A P31153 1/20 0.33
CYP19A1 P11511 2/20 0.33
CYP11B1 P15538 1/20 0.33
CYP11B2 P19099 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18667702 0.88 L3MBTL1 (0.41) MEN1KMT2AALDH1A1KDM4EHPGD
SCHEMBL18668061 0.84 KDM4E (0.46) MAPTALDH1A1KDM4EHPGDSMN1; SMN2
SCHEMBL16484375 0.82 MAPK10 (0.40) MAPK10MAPK9MAPK8MEN1HSP90AA1
SCHEMBL18668057 0.82 CYP2A6 (0.38) MEN1KMT2AALDH1A1KDM4EHPGD
SCHEMBL18667701 0.82 HTR6 (0.35) MEN1HSP90AA1MAPTKMT2AALDH1A1
SCHEMBL18668027 0.82 CYP1A2 (0.33) MAPTALDH1A1HPGD
SCHEMBL18667704 0.82 HTR3A (0.38) MAPK10MAPK9MAPK8HSP90AA1ALDH1A1
SCHEMBL19844141 0.82 LMNA (0.31) MAPT
SCHEMBL18668012 0.81 KMT2A (0.35) MEN1MAPTKMT2AALDH1A1KDM4E
SCHEMBL18667712 0.80 ESR1 (0.39) MAPK10MAPK9MAPK8MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10421721-B2 Heterocyclic compound and organic light emitting device comprising same LG CHEM, LTD. (KR) 2019-09-24 US disclosed
EP-3351531-A1 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING SAME LG Chem, Ltd. (KR) 2018-07-25 EP disclosed
US-20180037547-A1 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING SAME LG CHEM, LTD. (KR) 2018-02-08 US disclosed
US-20180037547-A1 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING SAME LG CHEM, LTD. (KR) 2018-02-08 US disclosed
WO-2017047992-A1 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING SAME 주식회사 엘지화학 2017-03-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10421721-B2 Heterocyclic compound and organic light emitting device comprising same CRY1, CRY2, PER2 MAPK10 4471/4885MAPK9 3787/4885MAPK8 4034/4885
US-20180037547-A1 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING SAME CRY1, CRY2, PER2 MAPK10 4471/4885MAPK9 3787/4885MAPK8 4034/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.