Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.43 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL286882 | 1.00 | HIF1A (0.56) | HIF1ATRAP1CHRNA7ALDH1A1CYP1A2 | |
| Bromide SCHEMBL2446607 | 1.00 | HIF1A (0.56) | HIF1ATRAP1CHRNA7ALDH1A1CYP1A2 | |
| Bromide SCHEMBL678415 | 1.00 | HIF1A (0.56) | HIF1ATRAP1CHRNA7ALDH1A1CYP1A2 | |
| Bromide SCHEMBL362235 | 1.00 | HIF1A (0.56) | HIF1ATRAP1CHRNA7ALDH1A1CYP1A2 | |
| Bromide SCHEMBL7759526 | 1.00 | HIF1A (0.56) | HIF1ATRAP1CHRNA7ALDH1A1CYP1A2 | |
| Bromide SCHEMBL635580 | 1.00 | HIF1A (0.56) | HIF1ATRAP1CHRNA7ALDH1A1CYP1A2 | |
| Bromide SCHEMBL8775234 | 1.00 | HIF1A (0.56) | HIF1ATRAP1CHRNA7ALDH1A1CYP1A2 | |
| Bromide SCHEMBL164301 | 1.00 | HIF1A (0.56) | HIF1ATRAP1CHRNA7ALDH1A1CYP1A2 | |
| Bromide SCHEMBL2979400 | 1.00 | HIF1A (0.56) | HIF1ATRAP1CHRNA7ALDH1A1CYP1A2 | |
| Bromide SCHEMBL1963378 | 1.00 | HIF1A (0.56) | HIF1ATRAP1CHRNA7ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0213547-B1 | CYCLOHEXANEALKANOIC ACIDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-12-27 | — | — | EP | claimed |
| US-4179446-A | DEAMINATION OF GLUMAIC ACID, CYCLIZATION, HALOACYLATION, REDUCTION | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) | 1979-12-18 | — | — | US | claimed |
| US-12625142-B2 | Assay for measuring binding affinity for cardiolipin of biologically active compounds | LATVIAN INSTITUTE OF ORGANIC SYNTHESIS (LV) | 2026-05-12 | — | — | US | disclosed |
| US-20250361217-A1 | FATTY ACID COMPOUNDS | UNIV PITTSBURGH COMMONWEALTH SYS HIGHER EDUCATION (US) | 2025-11-27 | — | — | US | disclosed |
| US-12459910-B2 | Mitochondrial therapeutic agents | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2025-11-04 | — | — | US | disclosed |
| EP-4543842-A1 | FATTY ACID COMPOUNDS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2025-04-30 | — | — | EP | disclosed |
| US-20240409521-A1 | MITOCHONDRIAL THERAPEUTIC AGENTS | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2024-12-12 | — | — | US | disclosed |
| US-12029797-B2 | Fatty acid derivative labeled with positron-emitting radionuclide | ASTELLAS PHARMA INC. (JP) | 2024-07-09 | — | — | US | disclosed |
| WO-2023250486-A1 | FATTY ACID COMPOUNDS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2023-12-28 | — | — | WO | disclosed |
| EP-4200609-B1 | AN ASSAY FOR MEASURING BINDING AFFINITY FOR CARDIOLIPIN OF BIOLOGICALLY ACTIVE COMPOUNDS | LATVIAN INST ORGANIC SYNTHESIS (LV) | 2023-12-27 | — | — | EP | disclosed |
| US-20230243840-A1 | An assay for measuring binding affinity for cardiolipin of biologically active compounds | LATVIAN INSTITUTE OF ORGANIC SYNTHESIS (LV) | 2023-08-03 | — | — | US | disclosed |
| EP-0228045-A2 | Aromatic thioethers | CIBA-GEIGY AG (CH) | 1987-07-08 | — | — | EP | disclosed |
| US-4649215-A | ANTIALLERGENS | CIBA-GEIGY CORPORATION (US) | 1987-03-10 | — | — | US | disclosed |
| CN-85104470-A | The method for preparing arythydroxamtes | — | 1986-10-01 | — | — | CN | disclosed |
| US-4607053-A | L2POXYGENASE INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1986-08-19 | — | — | US | disclosed |
| EP-0170048-A2 | Aliphatic thioethers | CIBA-GEIGY AG (CH) | 1986-02-05 | — | — | EP | disclosed |
| EP-0161939-A2 | Arylhydroxamates | E.R. Squibb & Sons, Inc. (US) | 1985-11-21 | — | — | EP | disclosed |
| US-4432906-A | ANTIALLERGENS, BRONCHODILATOR | HOFFMANN-LA ROCHE INC. (US) | 1984-02-21 | — | — | US | disclosed |
| US-4391827-A | 3-(2-Hydroxy-4-(substituted)phenyl)-cycloalkanone and cycloalkanol analgesic agents and intermediates therefor | PFIZER INC. (US) | 1983-07-05 | — | — | US | disclosed |
| US-4306097-A | 3-[2-Hydroxy-4-(substituted)phenyl]-cycloalkanol analgesic agents | PFIZER INC. (US) | 1981-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240409521-A1 | MITOCHONDRIAL THERAPEUTIC AGENTS | TFAM, TXNRD2, AIFM1 | HIF1A 387/4885TRAP1 55/4885CHRNA7 4489/4885 |
| US-12459910-B2 | Mitochondrial therapeutic agents | TFAM, TXNRD2, AIFM1 | HIF1A 387/4885TRAP1 55/4885CHRNA7 4489/4885 |
| US-12625142-B2 | Assay for measuring binding affinity for cardiolipin of biologically active compounds | TIMM50, TIMM10, TIMM44 | HIF1A 4701/4885TRAP1 86/4885CHRNA7 4278/4885 |
| US-12029797-B2 | Fatty acid derivative labeled with positron-emitting radionuclide | FABP3, FFAR3, FFAR1 | HIF1A 1676/4885TRAP1 744/4885CHRNA7 3438/4885 |
| US-20250361217-A1 | FATTY ACID COMPOUNDS | FASN, FABP2, ELOVL1 | HIF1A 3591/4885TRAP1 2260/4885CHRNA7 4130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.