SCHEMBL1869730

SCHEMBL1869730

Cn1cnc2ccc(C(=O)O)cc21

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 2/20 0.60
HCAR3 P49019 2/20 0.53
TNKS O95271 1/20 0.52
TNKS2 Q9H2K2 1/20 0.52
CHRNA7 P36544 1/20 0.51
HPGD P15428 3/20 0.49
KMT2A Q03164 2/20 0.47
DYRK1A Q13627 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
GAA P10253 2/20 0.46
ALDH1A1 P00352 2/20 0.46
NPC1 O15118 1/20 0.46
TP53 P04637 1/20 0.46
RAB9A P51151 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
LMNA P02545 1/20 0.46
HSD17B10 Q99714 1/20 0.46
KDM2B Q8NHM5 1/20 0.46
KDM4C Q9H3R0 1/20 0.46
MAPT P10636 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL599310 0.86 HCAR3 (0.65) FGFR1HCAR3HPGDKMT2AGAA
SCHEMBL16602284 0.86 ALDH1A1 (0.53) FGFR1TNKSTNKS2CHRNA7HPGD
SCHEMBL29819602 0.86 ALDH1A1 (0.53) FGFR1TNKSTNKS2CHRNA7HPGD
SCHEMBL11171 0.85 SMN1; SMN2 (0.50) FGFR1TNKSTNKS2CHRNA7HPGD
Hydrochloric Acid SCHEMBL7330424 0.85 HCAR3 (0.63) FGFR1HCAR3HPGDKMT2AGAA
SCHEMBL20570515 0.85 CHRNA7 (0.47) FGFR1TNKSTNKS2CHRNA7HPGD
SCHEMBL12094844 0.82 SMN1; SMN2 (0.48) FGFR1TNKSTNKS2CHRNA7HPGD
SCHEMBL3492748 0.82 FGFR1 (0.53) FGFR1CHRNA7HPGDKMT2ADYRK1A
SCHEMBL29555125 0.82 FGFR1 (0.53) FGFR1CHRNA7HPGDKMT2ADYRK1A
SCHEMBL10110841 0.82 CHRNA7 (0.46) FGFR1TNKSTNKS2CHRNA7HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 128 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122039051-A Composite coating for high-wear-resistance sliding bearing and preparation method thereof 成都工业职业技术学院 2026-05-15 CN claimed
CN-110167944-B Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors 联合疗法公司 2024-08-23 CN claimed
CN-122039051-A Composite coating for high-wear-resistance sliding bearing and preparation method thereof 成都工业职业技术学院 2026-05-15 CN disclosed
US-12595249-B2 Aryl ether-substituted heterocyclic compounds as glpir agonists MINDRANK AI LTD. (CN) 2026-04-07 US disclosed
EP-4704830-A2 MRGPRX2 INHIBITORS AND METHODS OF USE THEREOF Septerna, Inc. (US) 2026-03-11 EP disclosed
US-20260055062-A1 HETEROCYCLIC INHIBITORS OF MCT4 Vettore, LLC 2026-02-26 US disclosed
EP-4688144-A1 COMPOUNDS AS GLP-1R AGONISTS Terns Pharmaceuticals, Inc. (US) 2026-02-11 EP disclosed
US-12497384-B2 Aryl ether-substituted heterocyclic compounds as GLP1R agonists MINDRANK AI LTD. (CN) 2025-12-16 US disclosed
US-12492171-B2 Heterocyclic inhibitors of MCT4 Vettore, LLC (US) 2025-12-09 US disclosed
US-20250304553-A1 ARYL ETHER-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS GLP1R AGONISTS MINDRANK AI LTD. (CN) 2025-10-02 US disclosed
US-20250282757-A1 ARYL ETHER-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS GLP1R AGONISTS MINDRANK AI LTD. (CN) 2025-09-11 US disclosed
WO-2011057054-A1 ARYL- AND HETEROARYLCARBONYL DERIVATIVES OF HEXAHYDROINDENOPYRIDINE AND OCTAHYDROBENZOQUINOLINE VITAE PHARMACEUTICALS, INC. (US) 2011-05-12 WO disclosed
US-20040006104-A1 Neutrophil inhibitors to reduce inflammatory response THE PROCTER & GAMBLE COMPANY 2004-01-08 US disclosed
US-6410529-B1 DIETETICS; NON-INSULIN DEPENDENT DIABETES; SLEEP DISORDERS SMITHKLINE BEECHAM P.L.C. (GB) 2002-06-25 US disclosed
WO-2002016327-A1 BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS NEUTROPHIL INHIBITORS THE PROCTER & GAMBLE COMPANY (US) 2002-02-28 WO disclosed
EP-0376624-B1 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation YAMANOUCHI PHARMA CO LTD (JP) 1994-09-14 EP disclosed
WO-1992022536-A1 VINYLIMIDAZOLES, VINYLTRIAZOLES AND VINYLTETRAZOLES WITH A BICYCLIC SUBSTITUENT GROUP SCHERING AKTIENGESELLSCHAFT, BERLIN UND BERGKAMEN (DE) 1992-12-23 WO disclosed
EP-0518457-A1 Bicyclic substituted vinylimidazoles, -triazoles and -tetrazoles SCHERING AKTIENGESELLSCHAFT (DE) 1992-12-16 EP disclosed
US-4977175-A GASTROINTESTINAL DISORDERS, ANTIEMETICS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1990-12-11 US disclosed
EP-0376624-A1 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1990-07-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12492171-B2 Heterocyclic inhibitors of MCT4 SLC16A3, SLC16A1, MCTS1 FGFR1 1689/4885HCAR3 117/4885TNKS 1787/4885
US-12497384-B2 Aryl ether-substituted heterocyclic compounds as GLP1R agonists GLP1R, GIPR, GCGR FGFR1 53/4885HCAR3 128/4885TNKS 4076/4885
US-12595249-B2 Aryl ether-substituted heterocyclic compounds as glpir agonists GLP1R, GIPR, GCGR FGFR1 210/4885HCAR3 215/4885TNKS 4340/4885
US-20250304553-A1 ARYL ETHER-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS GLP1R AGONISTS GLP1R, GIPR, GCGR FGFR1 39/4885HCAR3 122/4885TNKS 3929/4885
US-20040006104-A1 Neutrophil inhibitors to reduce inflammatory response MPO, SERPINB1, NCF1 FGFR1 2126/4885HCAR3 379/4885TNKS 1327/4885
US-20250282757-A1 ARYL ETHER-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS GLP1R AGONISTS GLP1R, GIPR, GCGR FGFR1 59/4885HCAR3 108/4885TNKS 4192/4885
US-20260055062-A1 HETEROCYCLIC INHIBITORS OF MCT4 SLC16A1, SLC16A3, SLC16A7 FGFR1 1898/4885HCAR3 532/4885TNKS 3634/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.