Cyclic Adenosine Monophosphate

Cyclic Adenosine Monophosphate

SCHEMBL18716064

Nc1ncnc2c1ncn2[C@@H]1O[C@H]2COP(=O)(O)OC2C1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
STING1 Q86WV6 14/20 1.00
LMNA P02545 2/20 1.00
RAPGEF3 O95398 2/20 1.00
KMT2A Q03164 2/20 1.00
GMNN O75496 1/20 1.00
BLM P54132 1/20 1.00
NPSR1 Q6W5P4 1/20 1.00
RAPGEF4 Q8WZA2 1/20 1.00
RXFP1 Q9HBX9 1/20 0.80
PDE4A P27815 1/20 0.78
PDE4B Q07343 1/20 0.78
PDE4C Q08493 1/20 0.78
PDE4D Q08499 1/20 0.78
MEN1 O00255 1/20 0.78
ALDH1A1 P00352 1/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15893189 1.00 STING1 (1.00) STING1LMNARAPGEF3KMT2AGMNN
SCHEMBL18934079 1.00 STING1 (1.00) STING1LMNARAPGEF3KMT2AGMNN
SCHEMBL22434642 1.00 STING1 (1.00) STING1LMNARAPGEF3KMT2AGMNN
Cyclic Adenosine Monophosphate SCHEMBL23829653 1.00 STING1 (1.00) STING1LMNARAPGEF3KMT2AGMNN
Cyclic Adenosine Monophosphate SCHEMBL23829820 1.00 STING1 (1.00) STING1LMNARAPGEF3KMT2AGMNN
Cyclic Adenosine Monophosphate SCHEMBL23829591 1.00 STING1 (1.00) STING1LMNARAPGEF3KMT2AGMNN
Cyclic Adenosine Monophosphate SCHEMBL23829670 1.00 STING1 (1.00) STING1LMNARAPGEF3KMT2AGMNN
Cyclic Adenosine Monophosphate SCHEMBL23829673 1.00 STING1 (1.00) STING1LMNARAPGEF3KMT2AGMNN
Cyclic Adenosine Monophosphate SCHEMBL20912149 1.00 STING1 (1.00) STING1LMNARAPGEF3KMT2AGMNN
Cyclic Adenosine Monophosphate SCHEMBL16558262 1.00 STING1 (1.00) STING1LMNARAPGEF3KMT2AGMNN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11819550-B2 Liquid protein formulations containing cyclic adenosine monophosphate (cAMP) or adenosine triphosphate (ATP) EAGLE BIOLOGICS, INC. (US) 2023-11-21 US disclosed
US-20210338706-A1 ADENOSINE ANALOG AND ITS USE IN REGULATING THE CIRCADIAN CLOCK NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2021-11-04 US disclosed
US-20210289794-A1 COMPOSITIONS AND RELATED METHODS FOR AGRICULTURE FLAGSHIP PIONEERING INNOVATIONS V, INC. 2021-09-23 US disclosed
US-20210060188-A1 TCO CONJUGATES AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK 2021-03-04 US disclosed
US-20210038718-A1 Liquid Protein Formulations Containing Organophosphates EAGLE BIOLOGICS, INC. 2021-02-11 US disclosed
US-10821184-B2 Liquid protein formulations containing thiamine pyrophosphate (TPP) EAGLE BIOLOGICS, INC. (US) 2020-11-03 US disclosed
US-20200255388-A1 EPAC ANTAGONISTS THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2020-08-13 US disclosed
US-20190185479-A1 BICYCLIC NITROGENATED HETEROCYCLIC COMPOUND MITSUBISHI TANABE PHARMA CORPORATION (JP) 2019-06-20 US disclosed
US-10167498-B1 Gradient elution moving boundary electrophoresis for use with complex samples and detection of toxins APPLIED RES ASSOCIATES INC (US) 2019-01-01 US disclosed
WO-2018133854-A1 ADENOSINE ANALOG AND ITS USE IN REGULATING THE CIRCADIAN CLOCK NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2018-07-26 WO disclosed
US-20180153997-A1 Liquid Protein Formulations Containing Organophosphates EAGLE BIOLOGICS, INC. 2018-06-07 US disclosed
US-9913905-B2 Liquid pharmaceutical formulations for injection comprising thiamine pyrophosphate 1-(3-aminopropyl)-2-methyl-1H-imidazole and uses thereof EAGLE BIOLOGICS, INC. (US) 2018-03-13 US disclosed
US-20170095580-A1 TCO CONJUGATES AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2017-04-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210060188-A1 TCO CONJUGATES AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS FCGR2A, PAICS, CD47 STING1 4200/4885LMNA 2921/4885RAPGEF3 3435/4885
US-11819550-B2 Liquid protein formulations containing cyclic adenosine monophosphate (cAMP) or adenosine triphosphate (ATP) PDE7A, PDE8A, PDE8B STING1 234/4885LMNA 2108/4885RAPGEF3 174/4885
US-10821184-B2 Liquid protein formulations containing thiamine pyrophosphate (TPP) PLPBP, ITPA, PLTP STING1 1077/4885LMNA 2577/4885RAPGEF3 1725/4885
US-20190185479-A1 BICYCLIC NITROGENATED HETEROCYCLIC COMPOUND PDE7B, PDE3A, PDE7A STING1 1656/4885LMNA 2370/4885RAPGEF3 758/4885
US-20170095580-A1 TCO CONJUGATES AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS FCGR2A, PAICS, CD47 STING1 4200/4885LMNA 2921/4885RAPGEF3 3435/4885
US-20210338706-A1 ADENOSINE ANALOG AND ITS USE IN REGULATING THE CIRCADIAN CLOCK PER2, CRY1, ADORA2A STING1 1530/4885LMNA 2993/4885RAPGEF3 862/4885
US-20210038718-A1 Liquid Protein Formulations Containing Organophosphates IGFBP1, IGFBP5, IGF2BP1 STING1 680/4885LMNA 2987/4885RAPGEF3 2000/4885
US-20180153997-A1 Liquid Protein Formulations Containing Organophosphates IGFBP1, IGFBP5, IGF2BP1 STING1 680/4885LMNA 2987/4885RAPGEF3 2000/4885
US-20200255388-A1 EPAC ANTAGONISTS EPAS1, GPR139, CRACR2A STING1 2027/4885LMNA 1424/4885RAPGEF3 5/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.